Asymmetric organozincate additions to ethyl 2,2,2-trifluoropyruvate

Synlett

Volumn , Issue 14, 2007, Pages 2193-2196

  Gosselin, Francis ^a   Britton, Robert A ^a   Mowat, Jeffrey ^a   O'Shea, Paul D ^a   Davies, Ian W ^b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

keto ester; Asymmetric organometallic addition; BINOL; Trifluoropyruvate; Zincate

Indexed keywords

ALPHA TRIFLUOROMETHYL ALPHA HYDROXY ACID; ETHYL 2,2,2 TRIFLUOROPYRUVIC ACID; HYDROXYACID; ORGANOZINCATE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZINC DERIVATIVE;

ADDITION REACTION; ARTICLE; CHIRALITY; CHROMATOGRAPHY; ENANTIOMER; SYNTHESIS;

EID: 34548736485     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-984911     Document Type: Article

References (27)

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27. 3 at -61.5 ppm): δ = -77.3. Chiral GC analysis (methyl ester): Cyclodex-B column, 50°C for 1 min, 5°C/min to 95°C, hold at 95°C for 1 min, 20°C/min to 200°C, injector 180°C, detector 250°C, split 10:1, 13.5 psi He, S-enantiomer at 6.10 min, R-enantiomer at 6.83 min.