Interactions of TRF2 with model telomeric ends

Biochemical and Biophysical Research Communications

Volumn 363, Issue 1, 2007, Pages 44-50

  Khan, Sheik J ^a   Yanez, Giscard ^a   Seldeen, Kenneth ^a   Wang, Hongda ^b   Lindsay, Stuart M ^b   Fletcher, Terace M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

DNA structure; G quadruplex; Telomere; TRF2

Indexed keywords

TELOMERIC REPEAT BINDING FACTOR 2;

ARTICLE; ATOMIC FORCE MICROSCOPY; DNA BINDING; DNA CLEAVAGE; DNA SEQUENCE; GEL MOBILITY SHIFT ASSAY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; TELOMERE;

BASE SEQUENCE; BINDING SITES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2;

EUKARYOTA;

EID: 34548720900     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.122     Document Type: Article

References (24)

1. Lingner J., Cooper J.P., and Cech T.R. Telomerase and DNA end replication: no longer a lagging strand problem?. Science 269 (1995) 1533-1534
2. McElligott R., and Wellinger R.J. The terminal DNA structure of mammalian chromosomes. EMBO J. 16 (1997) 3705-3714
3. Makarov V.L., Hirose Y., and Langmore J.P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88 (1997) 657-666
4. Fletcher T.M. Telomere higher-order structure and genomic instability. IUBMB Life 55 (2003) 443-449
5. Bilaud T., Brun C., Ancelin K., Koering C.E., Laroche T., and Gilson E. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 17 (1997) 236-239
6. de Lange T. Protection of mammalian telomeres. Oncogene 21 (2002) 532-540
7. van Steensel B., Smogorzewska A., and de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 92 (1998) 401-413
8. Karlseder J., Broccoli D., Dai Y., Hardy S., and de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283 (1999) 1321-1325
9. Karlseder J., Smogorzewska A., and de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 295 (2002) 2446-2449
10. Blanco R., Munoz P., Flores J.M., Klatt P., and Blasco M.A. Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 21 (2007) 206-220
11. Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., and de Lange T. Mammalian telomeres end in a large duplex loop. Cell 97 (1999) 503-514
12. Stansel R.M., de Lange T., and Griffith J.D. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J 20 (2001) 5532-5540
13. Amiard S., Doudeau M., Pinte S., Poulet A., Lenain C., Faivre-Moskalenko C., Angelov D., Hug N., Vindigni A., Bouvet P., Paoletti J., Gilson E., and Giraud-Panis M.J. A topological mechanism for TRF2-enhanced strand invasion. Nat. Struct. Mol. Biol. 14 (2007) 147-154
14. Court R., Chapman L., Fairall L., and Rhodes D. How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures. EMBO Rep. 6 (2005) 39-45
15. Fouche N., Cesare A.J., Willcox S., Ozgur S., Compton S.A., and Griffith J.D. The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats. J. Biol. Chem. 281 (2006) 37486-37495
16. Yanez G., Khan S., Pedroso I., and Fletcher T.M. DNA structure-dependent recruitment of telomeric proteins to single-stranded/double-stranded DNA junctions. Biochem. Biophys. Res. Comm 328 (2005) 49-56
17. Wang H., Bash R., Yodh J.G., Hager G.L., Lohr D., and Lindsay S.M. Glutaraldehyde modified mica: a new surface for atomic force microscopy of chromatin. Biophys. J. 83 (2002) 3619-3625
18. Yoshimura S.H., Maruyama H., Ishikawa F., Ohki R., and Takeyasu K. Molecular mechanisms of DNA end-loop formation by TRF2. Genes Cells 9 (2004) 205-218
19. Machwe A., Xiao L., and Orren D.K. TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. Oncogene 23 (2004) 149-156
20. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
21. Liu D., O'Connor M.S., Qin J., and Songyang Z. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279 (2004) 51338-51342
22. Ye J.Z., Donigian J.R., van Overbeek M., Loayza D., Luo Y., Krutchinsky A.N., Chait B.T., and de Lange T. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J. Biol. Chem. 279 (2004) 47264-47271
23. Bianchi A., and de Lange T. Ku binds telomeric DNA in vitro. J. Biol. Chem. 274 (1999) 21223-21227
24. Fairall L., Chapman L., Moss H., de Lange T., and Rhodes D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol. Cell 8 (2001) 351-361