Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults

Nutrition

Volumn 23, Issue 10, 2007, Pages 724-730

  Schubert, Ralf ^a   Kitz, Richard ^a   Beermann, Christopher ^b   Rose, Markus Andreas ^a   Baer, Patrick Carolus ^a   Zielen, Stefan ^a   Boehles, Hansjosef ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Numico Research Germany   (Germany)

Author keywords

Inflammatory mediators; Lipopolysaccharide; Polyunsaturated fatty acids

Indexed keywords

ARACHIDONIC ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 10; INTERLEUKIN 8; LEUKOTRIENE B4; LINOLENIC ACID; LIPOPOLYSACCHARIDE; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN E1; PROSTAGLANDIN E2; STEARIDONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ERYTHROCYTE MEMBRANE; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL;

ALPHA-LINOLENIC ACID; ALPROSTADIL; DIETARY SUPPLEMENTS; DINOPROSTONE; DOUBLE-BLIND METHOD; EICOSANOIC ACIDS; ERYTHROCYTE MEMBRANE; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-8; LEUKOTRIENE B4; MALE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548706990     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2007.06.012     Document Type: Article

References (29)

1. Simopoulos A.P. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54 (1991) 438-463
2. van Meeteren M.E., Teunissen C.E., Dijkstra C.D., and van Tol E.A. Antioxidants and polyunsaturated fatty acids in multiple sclerosis. Eur J Clin Nutr 59 (2005) 1347-1361
3. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 83 (2006) 456S-460S
4. Chapkin R.S., Davidson L.A., Ly L., Weeks B.R., Lupton J.R., and McMurray D.N. Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. J Nutr 137 (2007) 200S-204S
5. Calder P.C. Dietary modification of inflammation with lipids. Proc Nutr Soc 61 (2002) 345-358
6. Stulnig T.M. Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int Arch Allergy Immunol 132 (2003) 310-321
7. Dyerberg J., Bang H.O., and Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 28 (1975) 958-966
8. Matsuyama W., Mitsuyama H., Watanabe M., Oonakahara K., Higashimoto I., Osame M., et al. Effects of omega-3 polyunsaturated fatty acids on inflammatory markers in COPD. Chest 128 (2005) 3817-3827
9. Roland I., De Leval X., Evrard B., Pirotte B., Dogne J.M., and Delattre L. Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits. Mini Rev Med Chem 4 (2004) 659-668
10. Simopoulos A.P. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21 (2002) 495-505
11. Jho D.H., Cole S.M., Lee E.M., and Espat N.J. Role of omega-3 fatty acid supplementation in inflammation and malignancy. Integr Cancer Ther 3 (2004) 98-111
12. Zhao Y., Joshi-Barve S., Barve S., and Chen L.H. Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr 23 (2004) 71-78
13. Kapoor R., and Huang Y.S. Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. Curr Pharm Biotechnol 7 (2006) 531-534
14. Chilton L., Surette M.E., Swan D.D., Fonteh A.N., Johnson M.M., and Chilton F.H. Metabolism of gammalinolenic acid in human neutrophils. J Immunol 156 (1996) 2941-2947
15. Ziboh V.A., Miller C.C., and Cho Y. Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology. Prostaglandins Other Lipid Mediat 63 (2000) 3-13
16. Beermann C., Mobius M., Winterling N., Schmitt J.J., and Boehm G. Sn-position determination of phospholipid-linked fatty acids derived from erythrocytes by liquid chromatography electrospray ionization ion-trap mass spectrometry. Lipids 40 (2005) 211-218
17. Beermann C., Jelinek J., Reinecker T., Hauenschild A., Boehm G., and Klor H.U. Short term effects of dietary medium-chain fatty acids and n-3 long-chain polyunsaturated fatty acids on the fat metabolism of healthy volunteers. Lipids Health Dis 2 (2003) 10
18. Schmitt-Grohe S., Naujoks C., Bargon J., Wagner T.O., Schubert R., Hippe V., et al. Interleukin-8 in whole blood and clinical status in cystic fibrosis. Cytokine 29 (2005) 18-23
19. Barham J.B., Edens M.B., Fonteh A.N., Johnson M.M., Easter L., and Chilton F.H. Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 130 (2000) 1925-1931
20. Surette M.E., Koumenis I.L., Edens M.B., Tramposch K.M., and Chilton F.H. Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects. Clin Ther 25 (2003) 948-971
21. Zock P.L., Mensink R.P., Harryvan J., de Vries J.H., and Katan M.B. Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans. Am J Epidemiol 145 (1997) 1114-1122
22. James M.J., Gibson R.A., and Cleland L.G. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71 suppl (2000) 343S-348S
23. Kris-Etherton P.M., Taylor D.S., Yu-Poth S., Huth P., Moriarty K., Fishell V., et al. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 71 suppl (2000) 179S-188S
24. Calder P.C. Dietary fatty acids and the immune system. Lipids 34 suppl (1999) S137-S140
25. von Aulock S., Hermann C., and Hartung T. Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. J Immunol Methods 277 (2003) 53-63
26. Zaloga G.P., and Marik P. Lipid modulation and systemic inflammation. Crit Care Clin 17 (2001) 201-217
27. Fiorentino D.F., Zlotnik A., Mosmann T.R., Howard M., and O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 147 (1991) 3815-3822
28. Foey A.D., Parry S.L., Williams L.M., Feldmann M., Foxwell B.M., and Brennan F.M. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 160 (1998) 920-928
29. Murphy K.J., Galvin K., Kiely M., Morrissey P.A., Mann N.J., and Sinclair A.J. Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo. Asia Pac J Clin Nutr 15 (2006) 418-424