Overexpression of the phosphoprotein enriched in diabetes gene product (Ped/pea-15) in women with polycystic ovary syndrome

Clinical Endocrinology

Volumn 67, Issue 4, 2007, Pages 557-562

  Savastano, Silvia ^a   Orio Jr , Francesco ^a   Palomba, Stefano ^b   Cascella, Teresa ^a   Manguso, Francesco ^a   Lupoli, Gelsy Arianna ^a   Formisano, Pietro ^a   Lombardi, Gaetano ^a   Colao, Annamaria ^a   Beguinot, Francesco ^a   Valentino, Rossella ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PHOSPHOPROTEIN; PROTEIN PEA 15; PROTEIN PED; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING;

ADULT; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MULTIVARIATE ANALYSIS; OBESITY; PHOSPHOPROTEINS; POLYCYSTIC OVARY SYNDROME; TESTOSTERONE;

EID: 34548666621     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.02924.x     Document Type: Article

References (42)

1. Condorelli, G., Vigliotta, G., Iavarone, C., Caruso, M., Tocchetti, C.G., Andreozzi, F., Cafieri, A., Tecce, M.F., Formisano, P., Beguinot, L. Beguinot, F. (1998) PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. The EMBO Journal, 17, 3858 3866.
2. Condorelli, G., Vigliotta, G., Trencia, A., Maitan, M.A., Caruso, M., Miele, C., Oriente, F., Santopietro, S., Formisano, P. Beguinot, F. (2001) Protein kinase C (PKC)-α activation inhibits PKC-ζ and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells. Diabetes, 50, 1244 1252.
3. Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Oriente, F., Trencia, A., Fiory, F., Romano, C., Tiveron, C., Tatangelo, L., Troncone, G., Formisano, P. Beguinot, F. (2004) Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action. Molecular and Cellullar Biology, 24, 5005 5015.
4. Valentino, R., Autuori, E., Riccardi, G., Vaccaro, O., Trencia, A., Fiory, F., Alberobello, A.T., Miele, C., Formisano, F. Beguinot, F. (2003) PED expression in white blood cells in type 2 diabetic patients. Journal of Endocrinological Investigation, 26, 111.
5. Valentino, R., Lupoli, G.A., Raciti, G.A., Oriente, F., Marinaro, E., Della Valle, E., Salomone, M., Riccardi, G., Vaccaro, O., Donnarumma, G., Sesti, G., Hribal, M.L., Cardellini, M., Miele, C., Formisano, P. Beguinot, F. (2006) The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes. Diabetologia, 49, 3058 3066.
6. Dunaif, A. (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews, 18, 774 800.
7. Ehrmann, D.A. (2000) Glucose intolerance in the polycystic ovary syndrome: role of the pancreatic beta-cell. Journal of Pediatric Endocrinology & Metabolism, 13, 1299 1301.
8. Nestler, J.E. (2003) Insulin resistance syndrome and the polycystic ovary syndrome. Endocrine Practice, 8, 86 89.
9. Yildiz, B.O. (2004) Assessment of glucose intolerance and insulin sensitivity in polycystic ovary syndrome. Reproductive Biomedicine Online, 8, 649 656.
10. Ehrmann, D.A. (2005) Polycystic ovary syndrome. New England Journal of Medicine, 352, 1223 1236.
11. Ehrmann, D.A., Barnes, R.B., Rosenfield, R.L., Cavaghan, M.K. Imperial, J. (1999) Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care, 22, 141 146.
12. Legro, R.S., Kunselman, A.R., Dodson, W.C. Dunaif, A. (1999) Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. Journal of Clinical Endocrinology and Metabolism, 84, 165 169.
13. Conn, J.J., Jacobs, H.S. Conway, G.S. (2000) The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clinical Endocrinology, 52, 81 86.
14. Ovalle, F. Azziz, R. (2002) Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertility and Sterility, 77, 1095 1105.
15. Gambineri, A., Pelusi, C., Manicardi, E., Vicennati, V., Cacciari, M., Morselli-Labate, A.M., Pagotto, U. Pasquali, R. (2004) Glucose intolerance in a large cohort of Mediterranean women with polycystic ovary sindrome. Phenotype and associated factors. Diabetes, 53, 2353 2358.
16. Palmert, M.R., Gordon, C.M., Kartashov, A.I., Legro, R.S., Emans, S.J. Dunaif, A. (2002) Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 87, 1017 1023.
17. Azziz, R., Woods, K.S., Reyna, R., Key, T.J., Knocknenhauer, E.S. Yildiz, B.O. (2004) The prevalence and features of the polycystic ovary syndrome in an unselected population. Journal of Clinical Endocrinology and Metabolism, 89, 2745 2749.
18. Dunaif, A., Segal, K.R., Futterweit, W. Dubrjansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165 1174.
19. Dunaif, A., Wu, X., Lee, A. Diamanti-Kandarakis, E. (2001) Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS). American Journal of Physiology - Endocrinology and Metabolism, 281, E392 E399.
20. Marsden, P.J., Murdoch, A.P. Taylor, R. (2001) Tissue insulin sensitivity and body weight in polycystic ovary syndrome. Clinical Endocrinology, 55, 191 199.
21. The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction, 19, 41 47.
22. Barbieri, R.L. (1999) Infertility. In : S.S.C. Yen, R.B. Yaffe, R.L. Barbieri, eds. Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 4th edn. W.B. Saunders, Philadelphia, 562 593.
23. Ferriman, D. Gallwey, J.D. (1961) Clinical assessment of body hair growth in women. Journal of Clinical Endocrinology and Metabolism, 21, 1440 1447.
24. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 20, 1183 1197.
25. Orio, F. Jr., Palomba, S., Spinelli, L., Cascella, T., Tauchmanovà, L., Zullo, F., Lombardi, G. Colao, A. (2004a) The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study. Journal of Clinical Endocrinology and Metabolism, 89, 3696 3701.
26. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. Turner, R.C. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412 419.
27. Matsuda, M. DeFronzo, R.A. (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care, 22, 1462 1470.
28. Palomba, S., Affinito, P., Di Carlo, C., Bifulco, G. Nappi, C. (1999) Long-term administration of tibolone plus gonadotropin-releasing hormone agonist for the treatment of uterine leiomyomas: effectiveness and effects on vasomotor symptoms, bone mass, and lipid profiles. Fertility and Sterility, 72, 889 895.
29. Friedewald, W.T., Levy, R.I. Fredrickson, D.S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemstry, 18, 499 502.
30. Araujo, H., Danzinger, N., Cordier, J., Glowinski, J. Chneiweiss, H. (1993) Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. Journal of Biological Chemistry, 268, 5911 5920.
31. Yildiz, B.O., Yarali, H., Oguz, H. Bayraktar, M. (2003) Glucose intolerance, insulin resistance, and hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 88, 2031 2036.
32. Cibula, D. (2004) Is insulin resistance an essential component of PCOS?: the influence of confounding factors. Human Reproduction, 19, 757 759.
33. Orio, F. Jr., Palomba, S., De Simone, B., Di Biase, S., Russo, T., Labella, D., Zullo, F., Lombardi, G. Colao, A. (2004b) Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 89, 4588 4593.
34. Shulman, G.I. (2000) Cellular mechanisms of insulin resistance. Journal of Clinical Investigations, 106, 171 176.
35. Ehrmann, D.A. (2004) Genetic contribution to glucose intolerance in polycystic ovary syndrome. Reproductive Biomedicine Online, 9, 28 34.
36. Nestler, J.E. Jakubowicz, D.J. (1997) Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens. Journal of Clinical Endocrinology and Metabolism, 82, 524 530.
37. Korhonen, S., Hippelainen, M., Vanhala, M., Heinonen, S. Niskanen, L. (2003) The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study. Fertility and Sterility, 79, 1327 1334.
38. Pasquali, R. Gambineri, A. (2006) Insulin-sensitizing agents in polycystic ovary syndrome. European Journal of Endocrinology, 154, 763 775.
39. Sir-Petermann, T., Angel, B., Maliqueo, M., Carvajal, F., Santos, J.L. Perez-Bravo, F. (2002) Prevalence of type 2 diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome. Diabetologia, 45, 959 964.
40. Legro, R.S., Castracane, V.D. Kauffman, R.P. (2004) Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstetrical and Gynecological Survey, 59, 141 154.
41. Legro, R.S. (1999) Polycystic ovary syndrome. Phenotype to genotype. Endocrinology and Metabolism Clinics of North America, 28, 379 396.
42. Glintborg, D., Andersen, M., Hagen, C., Frystyk, J., Hulstrom, V., Flyvbjerg, A. Hermann, A.P. (2006) Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin, and body composition in hirsute PCOS patients and controls. European Journal of Endocrinology, 155, 337 345.