Melanocortin subtype 4 receptor agonists: Structure-activity relationships about the 4-alkyl piperidine core

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 20, 2007, Pages 5720-5723

  Sebhat, Iyassu K ^a   Lai, Yingjie ^a   Barakat, Khaled ^a   Ye, Zhixiong ^a   Tang, Rui ^a   Kalyani, Rubana N ^a   Vongs, Aurawan ^a   MacNeil, Tanya ^a   Weinberg, David H ^a   Cabello, M Angeles ^b   Maroto, Marta ^b   Teran, Ana ^b   Fong, Tung M ^a   Van der Ploeg, Lex H T ^a   Patchett, Arthur A ^a   Nargund, Ravi P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

Apetite; Erectile dysfunction; G protein coupled receptor; Metabolic disorder; Obesity; Peptidomimetic; Privileged structure

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR AGONIST; MELANOCORTIN 5 RECEPTOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKANES; AMIDES; HUMANS; MOLECULAR STRUCTURE; NITRILES; PIPERIDINES; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 34548631558     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.084     Document Type: Article

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