Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery

Obesity

Volumn 15, Issue 8, 2007, Pages 2012-2018

  Mora, Maria E Valera ^a   Manco, Melania ^a   Capristo, Esmeralda ^a   Guidone, Caterina ^a   Iaconelli, Amerigo ^a   Gniuli, Donatella ^a   Rosa, Giuseppina ^a   Calvani, Menotti ^a   Mingrone, Geltrude ^a,b  

^a Università Cattolica S Cuorc   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Biliopancreatic diversion; Ghrelin; Growth hormone; Growth hormone releasing hormone arginine test; Obese

Indexed keywords

ARGININE; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN; LEPTIN; PEPTIDE HORMONE; SOMATOMEDIN C;

ADULT; ARTICLE; BILIOPANCREATIC BYPASS; BLOOD; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; METABOLISM; METHODOLOGY; MIDDLE AGED; MORBID OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; WEIGHT REDUCTION;

ADULT; ARGININE; BILIOPANCREATIC DIVERSION; BLOOD GLUCOSE; FEMALE; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MIDDLE AGED; OBESITY, MORBID; PEPTIDE HORMONES; WEIGHT LOSS;

EID: 34548612761     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.240     Document Type: Article

References (30)

1. Arvat E, Di Vito L, Broglio F, et al. Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest. 2000;23:493-5.
2. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001;120:337-45.
3. Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003;37:649-61.
4. Gil-Campos M, Aguilera CM, Canete R, Gil A. Ghrelin: a hormone regulating food intake and energy homeostasis. Br J Nutr. 2006;96:201-26.
5. Broglio F, Gianotti L, Destefanis S, et al. The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state. Clin Endocrinol (Oxf). 2004;60:592-9.
6. Murdolo G, Lucidi P, Di Loreto C, et al. Insulin is required for prandial ghrelin suppression in humans. Diabetes. 2003; 52:2923-7.
7. Garcia JM, Garcia-Touza M, Hijazi RA, et al. Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J Clin Endocrinol Metab. 2005;90:2920-6.
8. Ueno H, Yamaguchi H, Kangawa K, Nakazato M. Ghrelin: a gastric peptide that regulates food intake and energy homeostasis. Regul Pept. 2005;15;126:11-9.
9. Broglio F, Gottero C, Benso A, et al. Ghrelin and the endocrine pancreas. Endocrine. 2003;22:19-24.
10. Popovic V, Miljic D, Pekic S, et al. Low plasma ghrelin level in gastrectomized patients is accompanied by enhanced sensitivity to the ghrelin-induced growth hormone release. J Clin Endocrinol Metab. 2005;90:2187-91.
11. Rojdmark S, Calissendorff J, Danielsson O, Brismar K. Hunger-satiety signals in patients with Graves' thyrotoxicosis before, during, and after long-term pharmacological treatment. Endocrine. 2005;27:55-61.
12. Giordano R, Picu A, Pagotto U, et al. The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease. Eur J Endocrinol. 2005;153:535-43.
13. Nagakawa E, Nagaya N, Okumura H, et al. Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci. 2002;103:325-8.
14. Mohlig M, Spranger J, Otto B, Ristow M, Tschop M, Pfeiffer AF. Euglycaemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest. 2002;25:RC36-8.
15. Broglio F, Prodam F, Me E, et al. Ghrelin: endocrine, metabolic and cardiovascular actions. J Endocrinol Invest. 2005;28(Suppl 5):23-5.
16. Shiiya T, Nakazato M, Minuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab. 2002;87: 240-4.
17. Yildiz BO, Suchard MA, Wong ML, McCann SM, Licinio J. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci USA. 2004;101:10434-9.
18. Valera Mora ME, Scarfone A, Valenza V, et al. Ghrelin does not influence gastric emptying in obese subjects. Obes Res. 2005;13:739-44.
19. Scacchi M, Pincelli AI, Cavagnini F. Growth hormone in obesity. Int J Obes. 1999;23:260-71.
20. De Marinis L, Bianchi A, Mancini A, et al. Growth hormone secretion and leptin in morbid obesity before and after biliopancreatic diversion: relationships with insulin and body composition. J Clin Endocrinol Metab. 2004;89: 174-80.
21. Koutkia P, Canavan B, Breu J, Johnson ML, Grinspon SK. Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab. 2004;287:E506-12.
22. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Oikawa S. Regulation of the ghrelin gene: growth hormone-releasing hormone up regulates ghrelin mRNA in the pituitary. Endocrinology. 2001;142:4154-7.
23. Aimaretti G, Baffoni C, DiVito L, et al. Comparisons among old and new provocative tests of GH secretion in 178 normal adults. Eur J Endocrinol. 2000;142:347-52.
24. Kamegai J, Tamura H, Shimizu T, et al. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology. 2004;145:3731-8.
25. Koutkia P, Schurgin S, Berry J, et al. Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women. Am J Physiol Endocrinol Metab. 2005;289:E814-22.
26. Adami GF, Cordera R, Andraghetti G, Camerini GB, Marinari G, Scopinaro N. Changes in serum ghrelin concentration following biliopancreatic diversion for obesity. Obes Res. 2004;12:684-7.
27. Holdstock C, Engstrom BE, Ohrvall M, Lind L, Sundbom M, Karisson FA. Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab. 2003;88:3177-83.
28. Broglio F, Gottero C, Prodam F, et al. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab. 2004;9:3062-5.
29. Langer FB, Reza Hoda MA, Bohdjalian A, et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15:1024-9.
30. Fruhbeck G, Diez-Caballero A, Gil MJ, et al. The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus. Obes Surg. 2004;14:606-12.