Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: Roles of T-cell receptor-mediated signals

Immunology

Volumn 122, Issue 2, 2007, Pages 210-221

  Ariga, Haruyuki ^a,c   Shimohakamada, Yoko ^a   Nakada, Makiyo ^a,d   Tokunaga, Takeshi ^a   Kikuchi, Takeshi ^a,e   Kariyone, Ai ^a   Tamura, Toshiki ^a,b   Takatsu, Kiyoshi ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Helper T cells (Th cells, Th0, Th1, Th2, Th3); MHC peptide interactions; T cell receptor (TCR); Transcription factors gene regulation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; DOWN REGULATION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; T-BOX DOMAIN PROTEINS; TH1 CELLS;

EID: 34548597042     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02630.x     Document Type: Article

References (42)

1. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986 136 : 2348 57.
2. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996 383 : 787 93.
3. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998 8 : 275 83.
4. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, Afkarian M, Murphy TL. Signaling and transcription in T helper development. Annu Rev Immunol 2000 18 : 451 94.
5. H1 differentiation - controlling the controllers. Nat Immunol 2002 3 : 506 8.
6. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol 2002 2 : 933 44.
7. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003 21 : 713 58.
8. Thierfelder WE, van Deursen JM, Yamamoto K et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996 382 : 171 4.
9. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996 382 : 174 7.
10. Takeda K, Tanaka T, Shi W et al. Essential role of Stat6 in IL-4 signalling. Nature 1996 380 : 627 30.
11. Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996 380 : 630 3.
12. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996 4 : 313 9.
13. Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998 9 : 765 75.
14. Pfeiffer C, Stein J, Southwood S, Ketelaar H, Sette A, Bottomly K. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med 1995 181 : 1569 74.
15. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med 1995 182 : 1579 84.
16. + T cells by antigenic peptides altered for TCR binding. J Immunol 1997 158 : 4237 44.
17. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. CD28 costimulation promotes the production of Th2 cytokines. J Immunol 1997 158 : 658 65.
18. + T cells toward the Th1 subset by CTLA-4 costimulation. J Immunol 2000 164 : 3554 62.
19. + T cells into high IL-4-producing effectors. Blood 1998 92 : 3338 45.
20. Akiba H, Miyahira Y, Atsuta M et al. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 2000 191 : 375 80.
21. Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH, Flavell RA. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001 409 : 97 101.
22. Salomon B, Bluestone JA. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 1998 161 : 5138 42.
23. Smits HH, de Jong EC, Schuitemaker JH, Geijtenbeek TB, van Kooyk Y, Kapsenberg ML, Wierenga EA. Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J Immunol 2002 168 : 1710 6.
24. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000 100 : 655 69.
25. Zhang WX, Yang SY. Cloning and characterization of a new member of the T-box gene family. Genomics 2000 70 : 41 8.
26. Lighvani AA, Frucht DM, Jankovic D et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc Natl Acad Sci USA 2001 98 : 15137 42.
27. + T cells. Nat Immunol 2002 3 : 549 57.
28. Mullen AC, High FA, Hutchins AS et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001 292 : 1907 10.
29. + helper T cell epitopes on mycobacterial antigen in mouse primed with Mycobacterium tuberculosis. Int Immunol 1997 9 : 227 37.
30. + Th1 cells. Infect Immun 1999 67 : 4312 9.
31. Takatsu K, Kariyone A. The immunogenic peptide for Th1 development. Int Immunopharmacol 2003 3 : 783 800.
32. Kariyone A, Tamura T, Kano H, Iwakura Y, Takeda K, Akira S, Takatsu K. Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-γ. Int Immunol 2003 15 : 1183 94.
33. + cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptide. Immunology 2006 117 : 47 58.
34. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 2002 295 : 338 42.
35. Seki E, Tsutsui H, Tsuji NM et al. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol 2002 169 : 3863 8.
36. + T helper phenotype development in a T cell receptor transgenic model. Int Immunol 2004 16 : 1691 9.
37. Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994 171 : 131 7.
38. + T cells. J Exp Med 1995 182 : 1591 6.
39. + T cell responses: the alternative approaches. Annu Rev Immunol 1997 15 : 297 322.
40. Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH. The role of CTLA-4 in regulating Th2 differentiation. J Immunol 1999 163 : 2634 9.
41. Radvanyi LG, Mills GB, Miller RG. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J Immunol 1993 150 : 5704 15.
42. Zhang X, Brunner T, Carter L et al. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med 1997 185 : 1837 49.