Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 21, 2007, Pages 6705-6715

  Gholap, Atul R ^a   Toti, Kiran S ^a   Shirazi, Fazal ^a   Kumari, Ratna ^b   Bhat, Manoj Kumar ^b   Deshpande, Mukund V ^a   Srinivasan, Kumar V ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Antifungal activity; Antiproliferative activity; Arylidenemalononitriles; Arylquinoline carbonitrile; Michael addition

Indexed keywords

1 [3 (2 AMINO 3 CYANO 5,6,7,8 TETRAHYDRO 5 OXOQUINOLIN 4 YL)PHENYL] 3 (4 METHOXYPHENYL)UREA; 1,3 BIS[3 (2 AMINO 3 CYANO 5,6,7,8 TETRAHYDRO 5 OXOQUINOLIN 4 YL)PHENYL]UREA; 2 AMINO 4 (3 AMINOPHENYL) 5,6,7,8 TETRAHYDRO 5 OXOQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO (2 CHLORPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (3 NITROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (3,4,5 TRIMETHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 CHLOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 FLUOROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 METHOXYPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 METHYLPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 (4 NITROPHENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5 OXO 4 PHENYL 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 5,6,7,8 TETRAHYDRO 5 OXO 4 4 TOLYLQUINOLINE 3 CARBOXAMIDE; 2 AMINO 5,6,7,8 TETRAHYDRO 5 OXO 4 [3 (2,5 DIOXO 2H PYRROL 1(5H) YL)PHENYL]QUINOLINE 3 CARBONITRILE; 3 AMINO 2 CYCLOHEXEN 1 ONE; AMPHOTERICIN B; ANTIFUNGAL AGENT; CYCLOHEXIMIDE; N (3 CYANO 5,6,7,8 TETRAHYDRO 5 OXO 4 4 TOLYLQUINOLIN 2 YL)ACETAMIDE; N 3 CYANO 5,6,7,8 TETRAHYDRO 5 OXO 4 [3 (2,5 DIOXO 2,4 PYRROL (5H)PHENYL)QUINOLIN 2 YL]ACETAMIDE; N [3 (2 AMINO 3 CYANO 5,6,7,8 TETRAHYDRO 5 OXOQUINOLIN 4 YL)PHENYL] 3 CHLOROPROPANAMIDE; N [3 (2 AMINO 3 CYANO 5,6,7,8 TETRAHYDRO 5 OXOQUINOLIN 4 YL)PHENYL] 3 MORPHOLINOPROPANAMIDE; N ACETYL N 3 CYANO 5,6,7,8 TETRAHYDRO 4 (4 METHYLPHENYL 5 OXO 4 4 TOLYLQUINOLIN 2 YL)ACETAMIDE; NIKKOMYCIN; PROPANOL; SOLVENT; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; AROMATIZATION; ARTICLE; BIOLOGICAL ACTIVITY; CATALYST; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MICHAEL ADDITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; FUNGI; HUMANS; HYPHAE; NITRILES; QUINOLINES;

EID: 34548542570     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.009     Document Type: Article

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