Disturbances in B- and T-cell homeostasis in rheumatoid arthritis: Suggested relationships with antigen-driven immune responses

Journal of Autoimmunity

Volumn 29, Issue 2-3, 2007, Pages 154-163

  Fekete, Andrea ^a   Soos, Lilla ^a   Szekanecz, Zoltan ^a   Szabo, Zoltan ^a   Szodoray, Peter ^a   Barath, Sandor ^a   Lakos, Gabriella ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Antigen specific immune response; Disease duration; Effector memory T cells; Memory B cells; Rheumatoid arthritis

Indexed keywords

ANTIGEN; AUTOANTIBODY; CD27 ANTIGEN; IMMUNOGLOBULIN D;

ADULT; ANTIBODY DETECTION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE DURATION; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY CELL; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HOMEOSTASIS; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; RHEUMATOID FACTOR;

EID: 34548539353     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.07.002     Document Type: Article

References (49)

1. Aarvak T., and Natvig J.B. Cell-cell interactions in synovitis: antigen presenting cells and T cell interaction in rheumatoid arthritis. Arthritis Res 3 (2001) 13-17
2. Weyand C.M., Goronzy J.J., Takemura S., and Kurtin P.J. Cell-cell interactions in synovitis. Interactions between T cells and B cells in rheumatoid arthritis. Arthritis Res 2 (2000) 457-463
3. Skapenko A., Lipsky P.E., and Schulze-Koops H. T cell activation as starter and motor of rheumatic inflammation. Curr Top Microbiol Immunol 305 (2006) 195-211
4. Furuzawa-Carballeda J., Vargas-Rojas M.I., and Cabral A.R. Autoimmune inflammation from the Th17 perspective. Autoimmun Rev 6 (2007) 169-175
5. Abbas A.K., Lohr J., and Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 28 (2007) 59-61
6. Fitzgerald J.E., Ricalton N.S., Meyer A.C., West S.G., Kaplan H., Behrendt C., et al. Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 154 (1995) 3538-3547
7. Masuko-Hongo K., Sekine T., Ueda S., Kobata T., Yamamoto K., Nishioka K., et al. Long-term persistent accumulation of CD8+ T cells in synovial fluid of rheumatoid arthritis. Ann Rheum Dis 56 (1997) 613-621
8. Vallbracht I., and Helmke K. Additional diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Autoimmun Rev 4 (2005) 389-394
9. van Venrooij W.J., Zendman A.J., and Pruijn G.J. Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis. Autoimmun Rev 6 (2006) 37-41
10. Samuels J., Ng Y.S., Coupillaud C., Paget D., and Meffre E. Impaired early B cell tolerance in patients with rheumatoid arthritis. J Exp Med 201 (2005) 1659-1667
11. Reparon-Schuijt C.C., van Esch W.J., van Kooten C., Schellekens G.A., de Jong B.A., van Venrooij W.J., et al. Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum 44 (2001) 41-47
12. Hirano T. Revival of the autoantibody model in rheumatoid arthritis. Nat Immunol 3 (2002) 342-344
13. Martinez-Gamboa L., Brezinschek H.P., Burmester G.R., and Dorner T. Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy. Autoimmun Rev 5 (2006) 437-442
14. Van Esch W.J., Reparon-Schuijt C.C., Hamstra H.J., Van Kooten C., Logtenberg T., Breedveld F.C., et al. Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection. Clin Exp Immunol 131 (2003) 364-376
15. Youinou P. B cell conducts the lymphocyte orchestra. J Autoimmun 28 (2007) 143-151
16. De Vita S., and Quartuccio L. Treatment of rheumatoid arthritis with rituximab: an update and possible indications. Autoimmun Rev 5 (2006) 443-448
17. Blank M., and Shoenfeld Y. B cell targeted therapy in autoimmunity. J Autoimmun 28 (2007) 62-68
18. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
19. Sallusto F., Geginat J., and Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22 (2004) 745-763
20. Hengel R.L., Thaker V., Pavlick M.V., Metcalf J.A., Dennis Jr. G., Yang J., et al. Cutting edge: L-selectin (CD62L expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigen. J Immunol 170 (2003) 28-32
21. Hamann D., Baars P.A., Rep M.H., Hooibrink B., Kerkhof-Garde S.R., Klein M.R., et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186 (1997) 1407-1418
22. Klein U., Rajewsky K., and Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188 (1998) 1679-1689
23. Agematsu K., Hokibara S., Nagumo H., and Komiyama A. CD27: a memory B-cell marker. Immunol Today 21 (2000) 204-206
24. Agematsu K., Nagumo H., Yang F.C., Nakazawa T., Fukushima K., Ito S., et al. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol 27 (1997) 2073-2079
25. Yamamoto K., and Yamada R. Genome-wide single nucleotide polymorphism analyses of rheumatoid arthritis. J Autoimmun 25 Suppl (2005) 12-15
26. Randen I., Mellbye O.J., Forre O., and Natvig J.B. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand J Immunol 41 (1995) 481-486
27. Arnett F.C., Edworthy S.M., Bloch D.A., McShane D.J., Fries J.F., Cooper N.S., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31 (1988) 315-324
28. Bohnhorst J.O., Thoen J.E., Natvig J.B., and Thompson K.M. Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjogren's syndrome. Scand J Immunol 54 (2001) 421-427
29. Manz R.A., Moser K., Burmester G.R., Radbruch A., and Hiepe F. Immunological memory stabilizing autoreactivity. Curr Top Microbiol Immunol 305 (2006) 241-257
30. Anolik J.H., Barnard J., Cappione A., Pugh-Bernard A.E., Felgar R.E., Looney R.J., et al. Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis Rheum 50 (2004) 3580-3590
31. Leandro M.J., Cambridge G., Ehrenstein M.R., and Edwards J.C. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum 54 (2006) 613-620
32. Ehrhardt G.R., Hsu J.T., Gartland L., Leu C.M., Zhang S., Davis R.S., et al. Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. J Exp Med 202 (2005) 783-791
33. Wei C., Anolik J., Cappione A., Zheng B., Pugh-Bernard A., Brooks J., et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol 178 (2007) 6624-6633
34. Roudier J. Association of MHC and rheumatoid arthritis. Association of RA with HLA-DR4: the role of repertoire selection. Arthritis Res 2 (2000) 217-220
35. Rosloniec E.F., Brandstetter T., Leyer S., Schwaiger F.W., and Nagy Z.A. Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models. J Autoimmun 27 (2006) 182-195
36. Neidhart M., Fehr K., Pataki F., and Michel B.A. The levels of memory (CD45RA-, RO+) CD4+ and CD8+ peripheral blood T-lymphocytes correlate with IgM rheumatoid factors in rheumatoid arthritis. Rheumatol Int 15 (1996) 201-209
37. Neidhart M., Pataki F., Schonbachler J., and Bruhlmann P. Flow cytometric characterisation of the "false naive" (CD45RA+, CD45RO-, CD29 bright+) peripheral blood T-lymphocytes in health and in rheumatoid arthritis. Rheumatol Int 16 (1996) 77-87
38. Ponchel F., Morgan A.W., Bingham S.J., Quinn M., Buch M., Verburg R.J., et al. Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis. Blood 100 (2002) 4550-4556
39. Maldonado A., Mueller Y.M., Thomas P., Bojczuk P., O'Connors C., and Katsikis P.D. Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients. Arthritis Res Ther 5 (2003) R91-R96
40. Saule P., Trauet J., Dutriez V., Lekeux V., Dessaint J.P., and Labalette M. Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+)compartment. Mech Ageing Dev 127 (2006) 274-281
41. Fritsch R.D., Shen X., Illei G.G., Yarboro C.H., Prussin C., Hathcock K.S., et al. Abnormal differentiation of memory T cells in systemic lupus erythematosus. Arthritis Rheum 54 (2006) 2184-2197
42. Colonna-Romano G., Aquino A., Bulati M., Di Lorenzo G., Listi F., Vitello S., et al. Memory B cell subpopulations in the aged. Rejuvenation Res 9 (2006) 149-152
43. Tan L.C., Mowat A.G., Fazou C., Rostron T., Roskell H., Dunbar P.R., et al. Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes. Arthritis Res 2 (2000) 154-164
44. Sawada S., and Takei M. Epstein-Barr virus etiology in rheumatoid synovitis. Autoimmun Rev 4 (2005) 106-110
45. Sawada S., Takei M., Inomata H., Nozaki T., and Shiraiwa H. What is after cytokine-blocking therapy, a novel therapeutic target-synovial Epstein-Barr virus for rheumatoid arthritis. Autoimmun Rev 6 (2007) 126-130
46. Fazou C., Yang H., McMichael A.J., and Callan M.F. Epitope specificity of clonally expanded populations of CD8+ T cells found within the joints of patients with inflammatory arthritis. Arthritis Rheum 44 (2001) 2038-2045
47. Edinger J.W., Bonneville M., Scotet E., Houssaint E., Schumacher H.R., and Posnett D.N. EBV gene expression not altered in rheumatoid synovia despite the presence of EBV antigen-specific T cell clones. J Immunol 162 (1999) 3694-3701
48. Lundberg K., Nijenhuis S., Vossenaar E.R., Palmblad K., van Venrooij W.J., Klareskog L., et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther 7 (2005) R458-R467
49. Kuhn K.A., Kulik L., Tomooka B., Braschler K.J., Arend W.P., Robinson W.H., et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 116 (2006) 961-973