Gluten enteropathy: Current views on diagnosis and treatment

Annals of Gastroenterology

Volumn 18, Issue 4, 2005, Pages 402-419

  Panteris, V ^a   Karamanolis, D G ^a,b  

^a Tzaneion General Hospital of Piraeus

^b NONE   (Greece)

Author keywords

Celiac; Diagnosis; Endoscopic markers; Gluten; Histology; Refractory sprue; Serology; Treatment

Indexed keywords

AZATHIOPRINE; BIOLOGICAL MARKER; CYCLOSPORIN; INTERLEUKIN 10; PREDNISOLONE; STEROID;

AUTOIMMUNE DISEASE; CELIAC DISEASE; CEREAL; CLINICAL FEATURE; DIAGNOSTIC ACCURACY; DIARRHEA; DISEASE RESISTANCE; DISEASE SEVERITY; DRUG DOSE TITRATION; DUODENUM BIOPSY; ENDOSCOPY; GENETICS; HISTOPATHOLOGY; HUMAN; PATHOGENESIS; REVIEW; SENSITIVITY AND SPECIFICITY; SEROLOGY;

EID: 34548537405     PISSN: 11087471     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

1. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119: 234-242.
2. Matysiak-Budnik T, Candalh C, Dugave C, et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003; 125:696-707.
3. Fasano A, Not T, Wang W, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000; 355:1518-1519.
4. Gonzalez S, Rodrigo L, Lopez-Vazquez A, et al. Association of MHC class I related gene B (MICB) to celiac disease. Am J Gastroenterol 2004; 99: 676-680.
5. Benahmed M, Mention JJ, Matysiak-Budnik T, et al. Celiac disease: a future without gluten-free diet?? Gastroenterology 2003; 125: 1264-1267.
6. Vader W, Kooy Y, Van Veelen P, et al. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002; 122: 1729-1237.
7. Vader LW, Stepniak DT, Bunnik EM, et al. Characterization of cereal-toxicity for celiac disease patients based on protein, homology in grains. Gastroenterology 2003; 125: 1105-1113.
8. Maiuri L, Ciacci C, Riccardelli I, et al. Association between innate response to gliadin activation of pathogenic T cells in coeliac disease. Lancet 2003; 362: 30-37.
9. Green PH, Jabri B. Coeliac disease. Lancet 2003; 362: 383-391.
10. Forsberg G, Fahlgren A, Horstedt P, Hammarstrom S, Hernell O, Hammarstrom ML. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am J Gastroenterol 2004; 99: 894-904.
11. Sollid LM, Gray GM. A role for bacteria in celiac disease? Am J Gastroenterol 2004; 99: 905-906.
12. Rewers M. Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 2005; 128: S47-S51.
13. Ciclitira PJ, King AL, Fraser JS. AGA technical review on Celiac-Sprue. American Gastroenterological Association. Gastroenterology 2001; 120: 1526-1540.
14. Maki M, Mustalahti K, Kokkonen J, et al. Prevalence of Celiac disease among children in Finland. N Engl J Med 2003; 19; 348: 2517-2524.
15. Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology 2005; 128: S74-S78.
16. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001; 120: 636-651.
17. Bai D, Brar P, Holleran S, et al. Effect of gender on the manifestations of celiac disease: evidence for greater mal-absorption in men. Scand J Gastroenterol 2005; 40: 183-187.
18. Sanders DS, Carter MJ, Hurlstone DP, et al. Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 2001; 358: 1504-1508.
19. Shahbazkhani B, Forootan M, Merat S, et al. Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment Pharmacol Ther 2003; 18: 231-235.
20. Spiegel BM, DeRosa VP, Gralnek IM, et al. Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis. Gastroenterology 2004; 126: 1721-1732.
21. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002; 346: 180-188.
22. Fasano A. Celiac disease - how to handle a clinical chameleon. N Engl J Med 2003; % 19; 348: 2568-2570.
23. Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002; 123: 1428-1435.
24. West J, Logan RF, Smith CJ, et al. Malignancy and mortality in people with coeliac disease: population based cohort study. BMJ 2004; 329: 716-719.
25. Corrao G, Corazza GR, Bagnardi V, et al. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 2001; 358: 356-361.
26. Korponay-Szabo IR, Dahlbom I, Laurila K, et al. Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 2003; 52: 1567-1571.
27. Tonutti E, Visentini D, Bizzaro N, et al. The role of anti-tissue transglutaminase assay for the diagnosis and monitoring of coeliac disease: a French-Italian multicentre study. J Clin Pathol 2003; 56: 389-393.
28. Tesei N, Sugai E, Vazquez H, et al. Antibodies to human recombinant tissue transglutaminase may detect coeliac disease patients undiagnosed by endomysial antibodies. Aliment Pharmacol Ther 2003; 17: 1415-1423.
29. Carroccio A, Vitale G, Di Prima L, et al. Comparison of anti-transglutaminase ELISAs and an anti-endomysial antibody assay in the diagnosis of celiac disease: a prospective study. Clin Chem 2002; 48: 1546-1550.
30. Wong RC, Wilson RJ, Steele RH, et al. A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits. J Clin Pathol 2002; 55: 488-494.
31. Leon F, Camarero C, Pena R, et al. Anti-transglutaminase IgA ELISA. clinical potential and drawbacks in celiac disease diagnosis. Scand J Gastroenterol 2001; 36: 849-853.
32. Rostom A, Dube C, Cranney A, et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 2005; 128: S38-S46.
33. Hill ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 2005; 128: S25-S32.
34. Dickey W, Hughes D. Erosions in the second part of the duodenum in patients with villous atrophy. Gastrointest Endosc 2004; 59: 116-118.
35. Clemente MG, Musu MP, Troncone R, et al. Enterocyte actin autoantibody detection: a new diagnostic tool in celiac disease diagnosis: results of a multicenter study. Am J Gastroenterol 2004; 99: 1551-1556.
36. Hansson T, Dahlbom I, Rogberg S, et al. Recombinant human tissue transglutaminase for diagnosis and followup of childhood coeliac disease. Pediatr Res 2002; 51: 700-705.
37. Green PH, Barry M, Matsutani M. Serologic tests for celiac disease. Gastroenterology 2003; 124: 585-586.
38. Green PH, Shane E, Rotterdam H, Forde KA, Grossbard L. Significance of unsuspected celiac disease detected at endoscopy. Gastrointest Endosc 2000; 51: 60-65.
39. Ravelli AM, Tobanelli P, Minelli L, Villanacci V, Cestari R. Endoscopic features of celiac disease in children. Gastrointest Endosc 2001; 54: 736-742.
40. Bardella MT, Minoli G, Radaelli F, Quatrini M, Bianchi PA, Conte D. Reevaluation of duodenal endoscopic markers in the diagnosis of celiac disease. Gastrointest Endosc 2000; 51: 714-716.
41. Niveloni S, Fiorini A, Dezi R, et al. Usefulness of videoduodenoscopy and vital dye staining as indicators of mucosal atrophy of celiac disease: assessment of interobserver agreement. Gastrointest Endcrsc 1998; 47: 223-229.
42. Gasbarrini A, Ojetti V, Cuoco L, et al. Lack of endoscopic visualization of intestinal villi with the "immersion technique" in overt atrophic celiac disease. Gastrointest Endosc 2003; 57: 348-351.
43. Olds G, McLoughlin R, O'Morian C, et al. Celiac disease for the endoscopist. Gastrointest Endosc 2002; 56: 407-415.
44. Tursi A, Brandimarte G, Giorgetti GM, et al. Endoscopic features of celiac disease in adults and their correlation with age, histological damage, and clinical form of the disease. Endoscopy 2002; 34: 787-792.
45. Kiesslich R, Mergener K, Naumann C, et al. Value of chromoendoscopy and magnifecation endoscopy in the evaluation of duodenal abnormalities: a prospective, randomized comparison. Endoscopy 2003; 35: 559-563.
46. Cammarota G, Martino A, Pirozzi GA, et al. Direct visualization of intestinal villi by high-resolution magnifying upper endoscopy: a validation study. Gastrointest Endosc 2004; 60: 732-738.
47. Hurlstone DP, Sanders DS. High-magnification immersion chromoscopic duodenoscopy permits visualization of patchy atrophy in celiac disease: an opportunity to target biopsies of abnormal mucosa. Gastrointest Endosc 2003; 58: 815-816.
48. Ravelli A, Bolognini S, Gambarotti M, et al. Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy. Am J Gastroenterol 2005; 100: 177-185.
49. Vogelsang H, Hanel S, Steiner B, et al. Diagnostic duodenal bulb biopsy in celiac disease. Endoscopy 2001; 33: 336-340.
50. Scoglio R, Di Pasquale G, Pagano G, et al. Is intestinal biopsy always needed for diagnosis of celiac disease? Am J Gastroenterol 2003; 98: 1325-1331.
51. Green PH, Murray JA. Routine duodenal biopsies to exclude celiac disease? Gastrointest Endosc 2003; 58: 92-95.
52. Lee SK, Lo W, Memeo L, et al. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet. Gastrointest Endosc 2003; 57: 187-191.
53. Jarvinen TT, Kaukinen K, Laurila K, et al. Intraepithelial lymphocytes in celiac disease. Am J Gastroenterol 2003; 98: 1332-1337.
54. Dickey W, Hughes DF. Histology of the terminal ileum in coeliac disease. Scand J Gastroenterol 2004; 39: 665-667.
55. Kakar S, Nehra V, Murray JA, et al. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 2003; 98: 2027-2033.
56. Leon F, Eiras P, Roy G, et al. Intestinal intraepithelial lymphocytes and anti-transglutaminase in a screening algorithm for coeliac disease. Gut 2002; 50: 740-741.
57. Jarvinen TT, Collin P, Rasmussen M, et al. Villous tip intraepithelial lymphocytes as markers of early-stage coeliac disease. Scand J Gastroenterol 2004; 39: 428-433.
58. Biagi F, Luinetti O, Campanella J, et al. Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? J Clin Pathol 2004; 57: 835-839.
59. Kupper C. Dietary guidelines and implementation for celiac disease. Gastroenterology 2005; 128: S121-S127.
60. O'Leary C, Wieneke P, Healy M, et al. Celiac disease and the transition from childhood to adulthood: a 28-year follow-up. Am J Gastroenterol 2004; 99: 2437-2441.
61. Hogberg L, Grodzinsky E, Stenhammar L. Better dietary compliance in patients with coeliac disease diagnosed in early childhood. Scand J Gastroenterol 2003; 38: 751-754.
62. Midhagen G, Hallett C. High rate of gastrointestinal symptoms in celiac patients living on a gluten-free diet: controlled study. Am J Gastroenterol 2003; 98: 2023-2026.
63. Jansson UH, Gudjonsdottir AH, Ryd W, et al. Two different doses of gluten show a dose-dependent response of enteropathy but not of serological markers during gluten challenge in children with coeliac disease. Acta Paediatr 2001; 90: 255-259.
64. Peraaho M, Kaukinen K, Paasikivi K, et al. Wheat-starch-based gluten-free products in the treatment of newly detected coeliac disease: prospective and randomized study. Aliment Pharmacol Ther 2003; 17: 587-594.
65. Collin P, Thorell L, Kaukinen K, et al. The safe threshold for gluten contamination in gluten-free products. Can trace amounts be accepted in the treatment of coeliac disease? Aliment Pharmacol Ther 2004; 19: 1277-1283.
66. Valdes I, Garcia E, Llorente M, et al. Innovative approach to low-level gluten determination in foods using a novel sandwich enzyme-linked immunosorbent assay protocol. Eur J Gastroenterol Hepatol 2003; 15: 465-474.
67. Spaenij-Dekking EH, Kooy-Winkelaar EM, Nieuwenhuizen WF, et al. A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin. Gut 2004; 53: 1267-1273.
68. Hogberg L, Laurin P, Falth-Magnusson K, et al. Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut 2004; 53: 649-654.
69. Peraaho M, Kaukinen K, Mustalahti K, et al. Effect of an oats-containing gluten-free diet on symptoms and quality of life in ceeliac disease. A randomized study. Scand J Gastroenterol 2004; 39: 27-31.
70. Janatuinen EK, Kemppainen TA, Julkunen RJ, et al. No harm from five year ingestion of oats in coeliac disease. Gut 2002; 50: 332-335.
71. Hollen E, Hogberg L, Stenhammar L, Falth-Magausson K, Magnusson KE. Antibodies to oat prolamines (avenins) in children with coeliac disease. Scand J Gastroenterol 2003; 38: 742-746.
72. Lundin KE, Nilsen EM, Scott HG, et al. Oats induced villous atrophy in coeliac disease. Gut 2003; 52: 1649-1652.
73. West J, Logan RF, Hill PG, et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003; 52: 960-965.
74. Ciacci C, Cavallaro R, dolla VN, d'Argenio G. The use of serum tTG-ab assay in patients on gluten-free diet as a measure of dietetic compliance. Gastroenterology 2002; 122: 588.
75. Dickey W, Hughes DF, McMillan SA. Disappearance of endomysial antibodies in treated celiac disease does not indicate histological recovery. Am J Gastroenterol 2000; 95: 712-714.
76. Vahedi K, Mascart F, Mary JY, et al. Reliability of anti-transglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease: Am J Gastroenterol 2003; 98: 1079-1087.
77. Ciacci C, Cirillo M, Cavallaro R, et al. Long-term follow-up of celiac adults on gluten-free diet: prevalence and correlates of intestinal damage. Digestion 2002; 66: 178-185.
78. Collin P, Maki M, Kaukinen K. Complete small intestine mucosal recovery is obtainable in the treatment of celiac disease. Gastrointest Endosc 2004; 59: 158-159.
79. Hallert C, Grant C, Grehn S, et al. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther 2002; 16: 1333-1339.
80. Ryan BM, Kelleher D. Refractory celiac disease. Gastroenterology 2000; 119: 243-251.
81. Tursi A, Brandimarte G, Giorgetti G. High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal. Am J Gastroenterol 2003; 98: 839-843.
82. Abdulkarim AS, Burgart LJ, See J, et al. Etiology of non-responsive celiac disease: results of a systematic approach. Am J Gastroenterol 2002; 97: 2016-2021.
83. Verkarre V, Asnafi V, Lecomte T, et al. Refractory coeliac sprue is a diffuse gastrointestinal disease. Gut 2003; 52: 205-211.
84. Cellier C, Delabesse E, Helmer C, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 2000; 356: 203-208.
85. Goerres MS, Meijer JW, Wahab PJ, et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment Pharmacol Ther 2003; 18: 487-494.
86. Mulder CJ, Wahab PJ, Moshaver B, et al. Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma. Scand J Gastroenterol Suppl 2000; 32-37.
87. Wahab PJ, Crusius JB, Meijer JW, et al. Cyclosporin in the treatment of adults with refractory coeliac disease - an open pilot study. Aliment Pharmacol Ther 2000; 14: 767-774.
88. Mulder CJ, Wahab PJ, Meijer JW, et al. A pilot study of recombinant human interleukin-10 in adults with refractory coeliac disease. Eur J Gastroenterol Hepatol 2001; 13: 1183-1188.
89. Farstad IN, Johansen FE, Vlatkovic L, et al. Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression. Gut 2002; 51: 372-378.
90. Meijer JW, Mulder CJ, Goerres MG, et al. Coeliac disease and (extra) intestinal T-cell lymphomas: definition, diagnosis and treatment. Scand J Gastroenterol Suppl 2004; 78-84.
91. Smedby KE, Akerman M, Hildebrand H, et al. Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma. Gut 2005; 54: 54-59.
92. Catassi C, Bearzi I, Holmes GK. Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 2005; 128: S79-S86.
93. Lomoschitz F, Schima W, Schober E, et al. Enteroclysis in adult celiac disease: diagnostic value of specific radiographic features. Eur Radiol 2003; 13: 890-896.
94. O'Malley ME, Wilson SR. US of gastrointestinal tract abnormalities with CT correlation. Radiographics 2003; 23: 59-72.
95. Dell'aquila P, Pietrini I, Barone M, et al. Small Intestinal Contrast Ultrasonography-Based Scoring System: A Promising Approach for the Diagnosis and Follow-Up of Celiac Disease. J Clin Gastroenterol 2005; 39: 591-595.
96. Fraquelli M, Colli A, Colucci A, et al. Accuracy of ultrasonography in predicting celiac disease. Arch Intern Med 2004; 164: 169-174.
97. Tomei E, Diacinn D, Marini M, et al. Abdominal CT findings may suggest coeliac disease. Dig Liver Dis 2005; 37: 402-406.
98. Boudiaf M, Jaff A, Soyer P, et al. Small-bowel diseases: prospective evaluation of multi-detector row helical CT enteroclysis in 107 consecutive patients. Radiology 2004; 233: 338-344.
99. Laghi A, Paolantonio P, Catalano C, et al. MR imaging of the small bowel using polyethylene glycol solution as an oral contrast agent in adults and children with celiac disease: preliminary observations. AJR Am J Roentgenol 2003; 180: 191-194.
100. Petroniene R, Dubcenco E, Baker JP, et al. Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement. Am J Gastroenterol 2005; 100: 685-694.
101. Horoldt BS, McAlindon ME, Stephenson TJ, et al. Making the diagnosis of coeliac disease: is there a role for push enteroscopy? Eur J Gastroenterol. Hepatol 2004; 16: 1143-1146.
102. Frenz MB, Mee AS. Making the diagnosis of coeliac disease: is there a role for push enteroscopy? Eur J Gastroenterol Hepatol 2004; 16: 1127-1129.
103. Tursi A, Brandimarte G, Giorgetti GM, et al. Effectiveness of the sorbitol H2 breath test in detecting histological damage among relatives of coeliacs. Scand J Gastroenterol 2003; 38:727-731.
104. Baldas V, Tommasini A, Trevisiol C, et al. Development of a novel rapid non-invasive screening test for coeliac disease. Gut 2000; 47:628-631.
105. Sorell L, Garrote JA, Acevedo B, Arranz E. One-step immunochromatographic assay for screening of coeliac disease. Lancet 2002; 359:945-946.
106. Liu E, Rewers M, Eisenbarth GS. Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease? Gastroenterology 2005; 128:S33-S37.