Analysis of expression and function of the inhibitory receptor ILT2 (CD85j/LILRB1/LIR-1) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE)

Journal of Autoimmunity

Volumn 29, Issue 2-3, 2007, Pages 97-105

  Monsivais Urenda A ^a   Nino Moreno P ^a   Abud Mendoza, C ^a,b   Baranda, L ^a,b   Layseca Espinosa, E ^a   Lopez Botet M ^c   Gonzalez Amaro R ^a  

^a UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^b HOSPITAL CENTRAL DR IGNACIO MORONES PRIETO   (Mexico)

^c HOSPITAL DEL MAR   (Spain)

Author keywords

CD85j; ILT2; LILRs; Lymphocytes; Systemic lupus erythematosus

Indexed keywords

CD19 ANTIGEN; IMMUNOGLOBULIN LIKE TRANSCRIPT 2 RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROMYALGIA; HUMAN; IMMUNOASSAY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD; APOPTOSIS; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CELL CYCLE; CELLS, CULTURED; FEMALE; FIBROMYALGIA; HUMANS; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC;

EID: 34548522452     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.05.003     Document Type: Article

References (47)

1. Alegre M.L., Frauwirth K.A., and Thompson C.B. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 1 (2001) 220-228
2. Frauwirth K.A., and Thompson C.B. Activation and inhibition of lymphocytes by costimulation. J Clin Invest 109 (2002) 295-299
3. Cambier J.C. Inhibitory receptors abound?. Proc Natl Acad Sci U S A 94 (1997) 5993-5995
4. Brown D., Trowsdale J., and Allen R. The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens 64 (2004) 215-225
5. Navarro F., and López-Botet M. Receptores de células NK específicos para moléculas HLA de clase I. Inmunología 20 (2001) 38-48
6. Cosman N., Fanger N., Borges L., Kubin M., Peterson L., and Hsu M.L. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7 (1997) 273-282
7. Guerra N., Michel F., Gati A., Gaudin C., Mishal Z., Escudier B., et al. Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction. Blood 100 (2002) 2874-2881
8. Sayós J., Martínez-Barriocanal A., Kitzig F., Bellón T., and López-Botet M. Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j. Biochem Biophys Res Commun 324 (2004) 640-647
9. Young N.T., Uhrberg M., Phillips J.H., Lanier L.L., and Parham P. Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL. J Immunol 166 (2001) 3933-3941
10. Saverino D., Fabbi M., Ghiotto F., Merlo A., Bruno S., Zarcone D., et al. The CD85/LIR-1/ILT2 Inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions. J Immunol 165 (2000) 3742-3755
11. Colonna M., Navarro F., Bellón T., Llano M., Garcia P., Samaridis J., et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186 (1997) 1809-1818
12. Saverino D., Ghiotto F., Merlo A., Bruno S., Battini L., Occhino M., et al. Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells. J Immunol 172 (2004) 5629-5637
13. Dietrich J., Cella M., and Colonna M. Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization. J Immunol 166 (2001) 2514-2521
14. Takai T. Paired immunoglobulin-like receptors and their MHC class I recognition. Immunology 115 (2005) 433-440
15. Tenca C., Merlo A., Merck E., Bates E.E., Saverino D., Simone R., et al. CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells. J Immunol 174 (2005) 6757-6763
16. Forte P., Pazmany L., Matter-Reissmann U.B., Stussi G., Schneider M.K., and Seebach J.D. HLA-G inhibits rolling adhesion of activated human NK cells on porcine endothelial cells. J Immunol 167 (2001) 6002-6008
17. Mills J.A. Systemic lupus erythematosus. N Engl J Med 329 (1994) 1871-1879
18. Mok C.C., and Lau C.S. Pathogenesis of systemic lupus erythematosus. J Clin Pathol 56 (2003) 481-490
19. Wandstrat A.E., Carr-Johnson F., Branch V., Gray H., Fairhurst A.M., Reimold A., et al. Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus. J Autoimmun 27 (2006) 153-160
20. Wu J.F., Yang Y.H., Wang L.C., Lee J.H., Shen E.Y., and Chiang B.L. Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus. J Autoimmun 27 (2006) 119-124
21. Lipsky P.E. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immun 2 (2001) 764-766
22. Kammer G.M., Perl A., Richardson B.C., and Tsokos G.C. Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum 46 (2002) 1139-1154
23. Grammer A.C., and Lipsky P.E. B cell abnormalities in systemic lupus erythematosus. Arthritis Res Ther 5 (2003) S22-S27
24. Takeuchi T., Tsuzaka K., and Abe T. Altered expression of the T cell receptor-CD3 complex in systemic lupus erythematosus. Int Rev Immunol 23 (2004) 273-291
25. Krishnan S., Kiang J.G., Fisher C.U., Nambiar M.P., Nguyen H.T., Kyttaris V.C., et al. Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells. J Immunol 125 (2005) 3417-3423
26. Liossis S.N., Ding X.Z., Dennis G.J., and Tsokos G.C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J Clin Invest 101 (1998) 1448-1457
27. Krishnan S., Nambiar M.P., Warke V.G., Fisher C.U., Mitchell J., Delaney N., et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 172 (2004) 7821-7831
28. Alvarado-Sánchez B., Portales-Pérez D., Baranda L., Layseca-Espinosa E., Abud-Mendoza C., Cubillas-Tejeda A.C., et al. Regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 27 (2006) 110-118
29. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 175 (2005) 8392-8400
30. Filaci G., Bacilieri S., Fravega M., Monetti M., Contini P., Ghio M., et al. Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus. J Immunol 166 (2001) 6452-6457
31. Crispin J., Martínez A., and Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 21 (2003) 273-276
32. Abbas A.K., Lohr J., and Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 28 (2007) 59-61
33. Wu H.Y., Monsonego A., and Weiner H.L. The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression. J Autoimmun 26 (2006) 116-126
34. Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25 (1982) 1271-1277
35. Guzman J., Cardiel M.H., Arce-Salinas A., Sanchez-Guerrero J., and Alarcon-Segovia D. Measurement of disease activity in systemic lupus erythematosus: prospective validation of 3 clinical indices. J Rheumatol 19 (1992) 1551-1558
36. Marazuela M., García-López M.A., Figueroa-Vega N., de la Fuente H., Alvarado-Sanchez B., Monsivais-Urenda A., et al. Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab 91 (2006) 3639-3646
37. Bolland S., and Ravetch J.V. Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis. Immunity 13 (2000) 277-285
38. Nakamura A., Yuasa T., Ujike A., Ono M., Nukiwa T., Ravetch J.V., et al. Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med 191 (2000) 899-906
39. Billadeau D.D., and Leibson P.J. ITAMs versus ITIMs: striking a balance during cell regulation. J Clin Invest 109 (2002) 161-168
40. Tedla N., Gibson K., McNeil H.P., Cosman D., Borges L., and Arm J.P. The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Am J Pathol 158 (2001) 1593-1598
41. Kuroki K., Tsuchiya N., Shiroishi M., Rasubala L., Yamashita Y., Matsuta K., et al. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet 14 (2005) 2469-2480
42. Jury E.C., Kabouridis P.S., Abba A., Mageed R.A., and Isenberg D.A. Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 48 (2003) 1343-1354
43. Oelke K., and Richardson B. Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression. Int Rev Immunol 23 (2004) 315-331
44. Renaudineau Y., Pers J.O., Bendaoud B., Jamin C., and Youinou P. Dysfunctional B cells in systemic lupus erythematosus. Autoimmun Rev 3 (2004) 516-523
45. Saverino D., Merlo A., Bruno S., Pistoia V., Grossi C.E., and Ciccone E. Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells. J Immunol 168 (2002) 207-215
46. Mahoney J.A., and Rosen A. Apoptosis and autoimmunity. Curr Opin Immunol 17 (2005) 583-588
47. Gaipl U.S., Munoz L.E., Grossmayer G., Lauber K., Franz S., Sarter K., et al. Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun 28 (2007) 114-121