MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism

Digestive Diseases and Sciences

Volumn 52, Issue 10, 2007, Pages 2757-2765

  Horikawa, Youhei ^a   Otaka, Michiro ^a   Komatsu, Koga ^a   Jin, Mario ^a   Odashima, Masaru ^a   Wada, Isao ^a   Matsuhashi, Tamotsu ^a   Ohba, Reina ^a   Oyake, Jinko ^a   Hatakeyama, Natsumi ^a   DuBois, Raymond N ^b   Watanabe, Sumio ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Apoptosis; Chemotherapeutic agents; COX 2; MEK ERK signaling

Indexed keywords

CYCLOOXYGENASE 2; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA DETERMINATION; DRUG POTENTIATION; IC 50; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CAMPTOTHECIN; CELL SURVIVAL; CYCLOOXYGENASE 2; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEOPLASMS, EXPERIMENTAL; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 34548500561     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9798-0     Document Type: Article

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