Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII

Journal of Biological Chemistry

Volumn 282, Issue 35, 2007, Pages 25367-25375

  Newell, Jennifer L ^a   Fay, Philip J ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CATALYST ACTIVITY; HYDROGEN BONDS; MOLECULAR BIOLOGY; MUTAGENESIS;

ORDERED PATHWAY; PROCOFACTOR ACTIVATION; THROMBIN; WILD-TYPE FACTOR;

PROTEINS;

ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; MUTANT PROTEIN; RECOMBINANT PROTEIN; THROMBIN;

ALPHA CHAIN; ARTICLE; CATALYSIS; KINETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; WILD TYPE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMICAL MODEL; CHEMISTRY; ENZYME ACTIVATION; GENE DELETION; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; CATALYSIS; ENZYME ACTIVATION; FACTOR VIII; FACTOR XA; HUMANS; MODELS, CHEMICAL; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE DELETION; THROMBIN;

EID: 34548486693     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703433200     Document Type: Article

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