Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa A regulatory role of the factor VIII heavy-chain region Lys713-Arg740

European Journal of Biochemistry

Volumn 240, Issue 2, 1996, Pages 365-372

  Donath, M J S H ^a  

^a CENTRAL LABORATORY   (Netherlands)

Author keywords

Acidic region; Activation; Blood coagulation; Factor viii; Proteolysis

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; THROMBIN;

AMINO ACID SEQUENCE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; ENZYME KINETICS; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTIBODIES, MONOCLONAL; FACTOR VIII; FACTOR XA; HUMANS; KINETICS; PEPTIDE FRAGMENTS; SEQUENCE DELETION; THROMBIN;

EID: 0029833923     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0365h.x     Document Type: Article

References (4)

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2. Vehar, G. A., Keyt, B., Eaton, D., Rodriguez, H., O'Brien, D. P., Rotblat, F., Oppermann, H., Keck, R., Wood, W. L, Harkins, R. N., Tuddenham, E. G. D., Lawn, R. M. & Capon, D. J. (1984) Structure of human factor VIII, Nature 312, 337-342.
3. Andersson, L. O., Forsman, N., Huang, K., Larsen, K., Lundin, A., Pavlu, B., Sandberg, H., Sewerin, K. & Smart, J. (1986) Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma, Proc. Natl Acad. Sci. USA 83, 2979-2983.
4. Eaton, D., Rodriguez, H. & Vehar, G. A. (1986) Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity, Biochemistry 25, 505-512.