Protection against bacteremic pneumococcal infection by antibody to pneumolysin

Journal of Infectious Diseases

Volumn 183, Issue 5, 2001, Pages 827-830

  Musher, Daniel M ^a,b,c   Phan, Hoang M ^a   Baughn, Robert E ^a,c,d  

^a MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Departments of Internal Medicine   (United States)

^c BCM MS280   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; PNEUMOLYSIN; TOXIN ANTIBODY;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; CONVALESCENCE; DOSE RESPONSE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; BACTEREMIA; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MICE; MIDDLE AGED; PNEUMOCOCCAL INFECTIONS; POLYSACCHARIDES, BACTERIAL; STREPTOLYSINS; TIME FACTORS; VIRULENCE;

EID: 0035282650     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/318833     Document Type: Article

References (15)

1. Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vitro
2. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae
3. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae
4. Genetic regulation of the capacity to make immunoglobulin G to pneumococcal capsular polysaccharides
5. Antibody to capsular polysaccharide of Streptococcus pneumoniae at the time of hospital admission for pneumococcal pneumonia
6. Bacteremic and nonbacteremic pneumococcal pneumonia: A prospective study
7. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae
8. Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro
9. Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency
10. Toxcity of pneumolysin to pulmonary alveolar epithelial cells
11. Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity and migration by pneumolysin
12. Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia
13. Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media
14. Impaired natural immunity to pneumolysin during human immunodeficiency virus infection in the United States and Africa
15. Role of pneumolysin's complement-activating activity during pneumococcal bacteremia in cirrhotic rats