Gene expression analysis of melanocortin system in vitiligo

Journal of Dermatological Science

Volumn 48, Issue 2, 2007, Pages 113-122

  Kingo, Külli ^a   Aunin, Eerik ^a   Karelson, Maire ^a   Philips, Mari Anne ^a   Rätsep, Ranno ^a   Silm, Helgi ^a   Vasar, Eero ^a   Soomets, Ursel ^a   Kõks, Sulev ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b ESTONIAN UNIVERSITY OF LIFE SCIENCES   (Estonia)

Author keywords

DCT; Melanocortin system; mRNA expression; TRP1; Vitiligo

Indexed keywords

MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; PROOPIOMELANOCORTIN; RNA; TYROSINASE RELATED PROTEIN 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; MALE; MELANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SKIN DEFECT; SKIN PIGMENTATION; STATISTICAL SIGNIFICANCE; UPREGULATION; VITILIGO;

ADULT; AGED; AGOUTI SIGNALING PROTEIN; AGOUTI-RELATED PROTEIN; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; MALE; MELANOCORTINS; MIDDLE AGED; RECEPTORS, MELANOCORTIN; SKIN; STRESS; VITILIGO;

EID: 34548475103     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2007.06.004     Document Type: Article

References (44)

1. Tobin D.J., Swanson N.N., Pittelkow M.R., Peters E.M., and Schallreuter K.U. Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 191 (2000) 407-416
2. Le Poole I.C., Das P.K., van den Wijngaard R.M., Bos J.D., and Westerhof W. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 2 (1993) 145-153
3. Ongenae K., Van Geel N., and Naeyaert J.M. Evidence for an autoimmune pathogenesis of vitiligo. Pigm Cell Res 16 (2003) 90-100
4. 2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc 4 (1999) 91-96
5. Moretti S., Spallanzani A., Amato L., Hautmann G., Gallerani I., Fabiani M., et al. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigm Cell Res 15 (2002) 87-92
6. Gantz I., and Fong T.M. The melanocortin system. Am J Physiol Endocrinol Metab 284 (2003) E468-E474
7. Kono M., Nagata H., Umemura S., Kawana S., and Osamura R.Y. In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 15 (2001) 2297-2299
8. Wakamatsu K., Graham A., Cook D., and Thody A.J. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigm Cell Res 10 (1997) 288-297
9. Tsatmali M., Yukitake J., and Thody A.J. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand) 45 (1999) 1029-1034
10. Roberts D.W., Newton R.A., Beaumont K.A., Helen Leonard J., and Sturm R.A. Quantitative analysis of MC1R gene expression in human skin cell cultures. Pigm Cell Res 19 (2006) 76-89
11. Getting S.J. Targeting melanocortin receptors as potential novel therapeutics. Pharmacol Ther 111 (2006) 1-15
12. Slominski A., Wortsman J., Luger T., Paus R., and Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80 (2000) 979-1020
13. Bohm M., Schiller M., and Luger T.A. Non-pigmentary actions of alpha-melanocyte-stimulating hormone-lessons from the cutaneous melanocortin system. Cell Mol Biol (Noisy-le-grand) 52 (2006) 61-68
14. Zhang L., Li W.H., Anthonavage M., and Eisinger M. Melanocortin-5 receptor: a marker of human sebocyte differentiation. Peptides 27 (2006) 413-420
15. Tsatmali M., Ancans J., and Thody A.J. Melanocyte function and its control by melanocortin peptides. J Histochem Cytochem 50 (2002) 125-133
16. Slominski A., Wortsman J., Mazurkiewicz J.E., Matsuoka L., Dietrich J., Lawrence K., et al. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 122 (1993) 658-666
17. Bastiaens M.T., ter Huurne J.A., Kielich C., Gruis N.A., Westendorp R.G., Vermeer B.J., et al. Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair. Am J Hum Genet 68 (2001) 884-894
18. Valverde P., Healy E., Jackson I., Rees J.L., and Thody A.J. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 11 (1995) 328-330
19. Krude H., Biebermann H., Luck W., Horn R., Brabant G., and Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19 (1998) 155-157
20. Healy E., Flannagan N., Ray A., Todd C., Jackson I.J., Matthews J.N., et al. Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair. Lancet 355 (2000) 1072-1073
21. Flanagan N., Healy E., Ray A., Philips S., Todd C., Jackson I.J., et al. Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation. Hum Mol Genet 9 (2000) 2531-2537
22. Kennedy C., ter Huurne J., Berkhout M., Gruis N., Bastiaens M., Bergman W., et al. Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J Invest Dermatol 117 (2001) 294-300
23. Suzuki I., Tada A., Ollmann M.M., Barsh G.S., Im S., Lamoreux M.L., et al. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin. J Invest Dermatol 108 (1997) 838-842
24. Voisey J., Kelly G., and Van Daal A. Agouti signal protein regulation in human melanoma cells. Pigm Cell Res 16 (2003) 65-71
25. Kanetsky P.A., Swoyer J., Panossian S., Holmes R., Guerry D., and Rebbeck T.R. A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am J Hum Genet 70 (2002) 770-775
26. Yang Y.K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S., Kent S.B., et al. Characterization of agouti-related protein binding to melanocortin receptors. Mol Endocrinol 13 (1999) 148-155
27. Thody A.J., Ridley K., Penny R.J., Chalmers R., Fisher C., and Shuster S. MSH peptides are present in mammalian skin. Peptides 4 (1983) 813-816
28. Pichler R., Sfetsos K., Badics B., Gutenbrunner S., and Aubock J. Vitiligo patients present lower plasma levels of alpha-melanotropin immunoreactivities. Neuropeptides 40 (2006) 177-183
29. Graham A., Westerhof W., and Thody A.J. The expression of alpha-MSH by melanocytes is reduced in vitiligo. Ann NY Acad Sci 885 (1999) 470-473
30. Na G.Y., Lee K.H., Kim M.K., Lee S.J., Kim D.W., and Kim J.C. Polymorphisms in the melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) genes in Korean vitiligo patients. Pigm Cell Res 16 (2003) 383-387
31. Kingo K., Philips M.A., Aunin E., Luuk H., Karelson M., Ratsep R., et al. MYG1, novel melanocyte-related gene, has elevated expression in vitiligo. J Dermatol Sci 44 (2006) 119-122
32. Curry J.L., Pinto W., Nickoloff B.J., and Slominski A.T. Human keratinocytes express functional alpha-MSH (MC1-R) receptors. In Vitro Cell Dev Biol Anim 37 (2001) 234-236
33. Moustafa M., Szabo M., Ghanem G.E., Morandini R., Kemp E.H., MacNeil S., et al. Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides. J Invest Dermatol 119 (2002) 1244-1253
34. Suzuki I., Cone R.D., Im S., Nordlund J., and Abdel-Malek Z.A. Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137 (1996) 1627-1633
35. Bohm M., Luger T.A., Tobin D.J., and Garcia-Borron J.C. Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol 126 (2006) 1966-1975
36. Machado Filho C.D., Almeida F.A., Proto R.S., and Landman G. Vitiligo: analysis of grafting versus curettage alone, using melanocyte morphology and reverse transcriptase polymerase chain reaction for tyrosinase mRNA. Sao Paulo Med J 123 (2005) 187-191
37. Jimbow K., Chen H., Park J.S., and Thomas P.D. Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase-related protein in vitiligo. Br J Dermatol 144 (2001) 55-65
38. Luger T.A., Scholzen T.E., Brzoska T., and Bohm M. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann NY Acad Sci 994 (2003) 133-140
39. Wintzen M., and Gilchrest B.A. Proopiomelanocortin, its derived peptides, and the skin. J Invest Dermatol 106 (1996) 3-10
40. Teofoli P., Motoki K., Lotti T.M., Uitto J., and Mauviel A. Propiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: modulation by cytokines. Exp Dermatol 6 (1997) 111-115
41. Wintzen M., Yaar M., Burbach J.P., and Gilchrest B.A. Proopiomelanocortin gene product regulation in keratinocytes. J Invest Dermatol 106 (1996) 673-678
42. Caixia T., Hongwen F., and Xiran L. Levels of soluble interleukin-2 receptor in the sera and skin tissue fluids of patients with vitiligo. J Dermatol Sci 21 (1999) 59-62
43. Grimes P.E., Morris R., Avaniss-Aghajani E., Soriano T., Meraz M., and Metzger A. Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol 51 (2004) 52-61
44. Fitzpatrick T.B., Miyamoto M., and Ishikawa K. The evolution of concepts of melanin biology. Arch Dermatol 96 (1967) 305-323