Growth hormone-regulated periportal expression of CYP2C7 in rat liver

Biochemical Pharmacology

Volumn 59, Issue 5, 2000, Pages 583-589

  Oinonen, Teija ^a   Ronis, Martin ^b   Wigell, Tanja ^a   Tohmo, Katri ^a   Badger, Thomas ^b   Lindros, Kai O ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CYP2C7; Cytochrome P450 expression; Ethanol treatment; Growth hormone regulation; Hypophysectomy; Liver gene zonation

Indexed keywords

ALCOHOL; CYTOCHROME P450 ISOENZYME; HUMAN GROWTH HORMONE; MESSENGER RNA; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONTROLLED STUDY; DRUG INFUSION; ENZYME REGULATION; FEMALE; GENE CONTROL; HYPOPHYSECTOMY; IMMUNOREACTIVITY; LIVER; LIVER PERIPORTAL ZONE; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; ETHANOL; FEMALE; GENE EXPRESSION REGULATION; GROWTH HORMONE; HYPOPHYSECTOMY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0033966169     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00344-5     Document Type: Article

References (37)

1. Gebhardt R. Metabolic zonation of the liver Regulation and implications for liver function . Pharmacol Ther. 52:1992;275-354.
2. Oinonen T., Lindros K.O. Zonation of hepatic cytochrome p450 enzyme expression and its regulation. Biochem J. 329:1998;17-35.
3. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily Update on new sequences, gene mapping, accession numbers and nomenclature . Pharmacogenetics. 6:1996;1-42.
4. Oinonen T., Nikkola E., Lindros K.O. Growth hormone mediates zone-specific gene expression in liver. FEBS Lett. 327:1993;237-240.
5. Oinonen T., Lindros K.O. Hormonal regulation of the zonated expression of cytochrome P450 3A in rat liver. Biochem J. 309:1995;55-61.
6. Oinonen T., Mode A., Lobie P.E., Lindros K.O. Zonation of cytochrome P450 enzyme expression in rat liver. Isozyme-specific regulation by pituitary dependent hormones. Biochem Pharmacol. 51:1996;1379-1387.
7. Legraverend C., Mode A., Wells T., Robinson I., Gustafsson J.-Å. Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J. 6:1992;711-718.
8. Leo M.A., Lieber C.S. New pathway for retinol metabolism in liver microsomes. J Biol Chem. 260:1985;5228-5231.
9. Leo M.A., Iida S., Lieber C.S. Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch Biochem Biophys. 234:1984;305-312.
10. Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P. Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3′ untranslated region of a liver mRNA. J Biol Chem. 261:1986;10667-10672.
11. Ram P.A., Waxman D.J. Pretranslational control by thyroid hormone of rat liver steroid 5-alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem. 265:1990;19223-19229.
12. PB1 (IIC6) gene expression . Mol Pharmacol. 38:1990;192-197.
13. Sasamura H., Nagata K., Yamazoe Y., Shimada M., Kato R. Effect of growth hormone on rat hepatic cytochrome P-450f mRNA A new mode of regulation . Mol Cell Endocrinol. 68:1990;53-60.
14. Westin S., Mode A., Murray M., Chen R., Gustafsson J.-Å. Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes. Mol Pharmacol. 44:1993;997-1002.
15. Westin S., Sonneveld E., van der Leede B.M., van der Saag P.T., Gustafsson J.-Å., Mode A. CYP2C7 expression in rat liver and hepatocytes Regulation by retinoids . Mol Cell Endocrinol. 129:1997;169-179.
16. Bandiera S., Ryan D.E., Levin W., Thomas P.E. Age- and sex-related expression of cytochromes p450f and P450g in rat liver. Arch Biochem Biophys. 248:1986;658-676.
17. Hakkak R., Korourian S., Ronis M.J., Ingelman-Sundberg M., Badger T.M. Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats. Biochem Pharmacol. 51:1996;61-69.
18. Ekman A.C., Vakkuri O., Ekman M., Leppaluoto J., Ruokonen A., Knip M. Ethanol decreases nocturnal plasma levels of thyrotropin and growth hormone but not those of thyroid hormones or prolactin in man. J Clin Endocrinol Metab. 81:1996;2627-2632.
19. Fernstrom J.D., Parkinson D.E., Ebaugh A.L. Acute, oral ethanol administration suppresses episodic growth hormone secretion in the male rat. Endocrinology. 136:1995;1059-1064.
20. Leo M.A., Lieber C.S. Hepatic vitamin A depletion in alcoholic liver injury. N Engl J Med. 307:1982;597-601.
21. Hu Y., Ingelman-Sundberg M., Lindros K.O. Induction mechanisms of cytochrome P450 2E1 in liver interplay between ethanol treatment and starvation . Biochem Pharmacol. 50:1995;155-161.
22. Quistorff B., Grunnet N. Dual-digitonin-pulse perfusion. Concurrent sampling of periportal and perivenous cytosol of rat liver for determination of metabolites and enzyme activities. Biochem J. 243:1987;87-95.
23. Ingelman-Sundberg M., Johansson I., Penttilä K.E., Glaumann H., Lindros K.O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver. Biochem Biophys Res Commun. 157:1988;55-60.
24. Böhlen P., Stein S., Dairman W., Udenfriend S. Fluorometric assay of proteins in the nanogram range. Arch Biochem Biophys. 155:1973;213-220.
25. Ronis M.J., Johansson A., Ingelman-Sundberg M. Biochemical characterization and regulation of P450EtOH-2, a new ethanol-inducible member of P450 gene family 2C. Alcohol Clin Exp Res. 15:1991;353.
26. Ronis M.J., Lumpkin C.K., Johansson A., Ingelman-Sundberg M., Badger T.M. P450EtOH2 A putative ethanol-inducible member of P450 gene family IIC under different regulation than P450 IIE1 . Ingelman-Sundberg M., Gustafsson J.A., Orrenius S. Drug Metabolizing Enzymes Genetics, Regulation and Toxicology. Proceedings of the VIIIth International Symposium on Microsomes and Drug Oxidations, Stockholm, Sweden, 1-6 July 1990 . 1990;92 Guiden Tryck AB, Stockholm.
27. Ronis M.J., Johansson A., Ingelman-Sundberg M., Badger T.M. Biochemical characterization and regulation of P450EtOH2, an ethanol-inducible member of P450 gene family 2C. Alcohol Clin Exp Res. 15:1991;353.
28. Saarinen J., Saarelainen R., Lindros K.O. A rapid method to study heterogeneous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates. Hepatology. 17:1993;466-469.
29. Katz E.D., Dong M.W. Rapid analysis and purification of polymerase chain reaction products by high-performance liquid chromatography. Biotechniques. 8:1990;546-555.
30. Lindros K.O., Oinonen T., Issakainen J., Nagy P., Thorgeisson S.S. Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver. Cell Biol Toxicol. 13:1997;257-262.
31. Faletto M.B., Linko P., Goldstein J.A. A single amino acid mutation (Ser180 - cys) determines the polymorphism in P450g (P4502C13) by altering protein stability. J Biol Chem. 267:1992;2032-2037.
32. Lindros K.O. Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. Gen Pharmacol. 28:1997;191-196.
33. Omiecinski C.J., Hassett C., Costa P. Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6 and CYP3A1. Mol Pharmacol. 38:1990;462-470.
34. Pampori N.A., Shapiro B.H. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol Pharmacol. 50:1996;1148-1156.
35. Waxman D.J., Ram P.A., Park S.-H., Choi H.K. Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription. J Biol Chem. 270:1995;13262-13270.
36. Waxman D.J., Zhao S., Choi H.K. Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter. J Biol Chem. 271:1996;29978-29987.
37. Ahluwalia G.S., Kaul L., Ahluwalia B.S. Evidence of facilitory effect of growth hormone on tissue vitamin A uptake in rats. J Nutr. 110:1980;1185-1193.