Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents

Acta Pharmacologica Sinica

Volumn 28, Issue 9, 2007, Pages 1365-1372

  Lü, Junxuan ^a   Kim, Sung Hoon ^a,b   Jiang, Cheng ^a   Lee, Hyojeong ^a,b   Guo, Junming ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Kyung Hee University   (South Korea)

Author keywords

Anti androgen; Chemo prevention; Herbal medicine; Prostate cancer; Pyranocoumarin

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANGELICA GIGAS EXTRACT; ANTIANDROGEN; BICALUTAMIDE; FINASTERIDE;

APOPTOSIS; CELL CYCLE ARREST; CLINICAL TRIAL; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; ORIENTAL MEDICINE; PHYTOCHEMISTRY; PROSTATE CANCER; REVIEW;

ANDROGEN ANTAGONISTS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BENZOPYRANS; BUTYRIC ACIDS; COUMARINS; DRUGS, CHINESE HERBAL; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN;

EID: 34548436056     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00683.x     Document Type: Review

References (40)

1. Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004 25 : 276 308.
2. Taplin ME, Balk SP. Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence. J Cell Biochem 2004 91 : 483 90.
3. Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 2002 62 : 1008 13.
4. Chen S, Song CS, Lavrovsky Y, Bi B, Vellanoweth R, Chatterjee B, et al. Catalytic cleavage of the androgen receptor messenger RNA and functional inhibition of androgen receptor activity by a hammerhead ribozyme. Mol endocrinol 1998 12 : 1558 66.
5. Kuratsukuri K, Sugimura K, Harimoto K, Kawashima H, Kishimoto T. "Decoy" of androgen-responsive element induces apoptosis in LNCaP cells. Prostate 1999 41 : 121 6.
6. Liao X, Tang S, Thrasher JB, Griebling TL, Li B. Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol Cancer Ther 2005 4 : 505 15.
7. Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, et al. The influence of finasteride on the development of prostate cancer. New Engl J Med 2003 349 : 215 24.
8. Balk SP, Ko YJ, Bubley GJ. Biology of prostate-specific antigen. J Clin Oncol 2003 21 : 383 91.
9. Young CY, Montgomery BT, Andrews PE, Qui SD, Bilhartz DL, Tindall DJ. Hormonal regulation of prostate-specific antigen messenger RNA in human prostatic adenocarcinoma cell line LNCaP. Cancer Res 1991 51 : 3748 52.
10. Montgomery BT, Young C Y, Bilhartz DL, Andrews PE, Prescott JL, Thompson NF, et al. Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP. Prostate 1992 21 : 63 73.
11. Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology 2001 142 : 4795 805.
12. Zi X, Agarwal R. Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proc Natl Acad Sci USA 1999 96 : 7490 5.
13. Lee HJ, Lee EO, Rhee YH, Ahn KS, Li GX, Jiang C, et al. An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. Carcinogenesis 2006 27 : 2455 63.
14. Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, et al. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res 2006 66 : 453 63.
15. Ahn KS, Sim WS, Kim IH. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med 1996 62 : 7 9.
16. Kim HH, Ahn KS, Han H, Choung SY, Choi SY, Kim IH. Decursin and PDBu: two PKC activators distinctively acting in the mega-karyocytic differentiation of K562 human erythroleukemia cells. Leuk Res 2005 29 : 1407 13.
17. Chi HJ, Kim HS. Studies on the components of Umbelliferae plants in Korea: pharmacological study of decursin, decursinol and nodakenin. Korean J Pharmacol 1970 1 : 25 32.
18. Guo J, Jiang C, Wang Z, Lee HJ, Hu H, Malewicz B, et al. A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther 2007 6 : 907 17.
19. Sheflin L, Keegan B, Zhang W, Spaulding SW. Inhibiting protea-somes in human HepG2 and LNCaP cells increases endogenous androgen receptor levels. Biochem Biophys Res Commun 2000 276 : 144 50.
20. Diehl JA, Zindy F, Sherr CJ. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 1997 11 : 957 72.
21. Ahn KS, Sim WS, Lee IK, Seu YB, Kim IH. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med 1997 63 : 360 1.
22. Sarker SD, Nahar L. Natural medicine: the genus Angelica. Curr Med Chem 2004 11 : 1479 500.
23. Schellhammer PF, Davis JW. An evaluation of bicalutamide in the treatment of prostate cancer. Clin Prostate Cancer 2004 2 : 213 9.
24. Hata K, Sano K. Studies on coumarins from the root of Angelica decursiva FR et SAV. I. The structure of decursin and decursidin. Yakugaku Zasshi 1969 89 : 549 57.
25. Konoshima M, Chi HJ, Hata K. Coumarins from the root of Angelica gigas Nakai. Chem Pharm Bull 1968 16 : 1139 40.
26. Woo YA, Kim HJ, Ze KR, Chung H. Near-infrared (NIR) spectroscopy for the non-destructive and fast determination of geographical origin of Angelicae gigantis Radix. J Pharm Biomed Anal 2005 36 : 955 9.
27. 2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry. Biomed Chromatogr 2006 20 : 1267 73.
28. Kang SY, Lee KY, Sung SH, Park MJ, Kim YC. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. Journal of natural products 2001 64 : 683 5.
29. Kang SY, Lee KY, Sung SH, Kim YC. Four new neuroprotective dihydropyranocoumarins from Angelica gigas. J Nat Prod 2005 68 : 56 9.
30. Choi SS, Han KJ, Lee HK, Han EJ, Suh HW. Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models. Biol Pharm Bull 2003 26 : 1283 8.
31. Choi SS, Han KJ, Lee JK, Lee HK, Han EJ, Kim DH, et al. Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sci 2003 73 : 471 85.
32. Kang SY, Lee KY, Park MJ, Kim YC, Markelonis GJ, Oh TH, et al. Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol Learn Mem 2003 79 : 11 8.
33. Lee S, Shin DS, Kim JS, Oh KB, Kang SS. Antibacterial coumarins from Angelica gigas roots. Arch Pharm Res 2003 26 : 449 52.
34. Lee Y Y, Lee S, Jin JL, Yun-Choi HS. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch Pharm Res 2003 26 : 723 6.
35. Ohshiro T, Namatame I, Lee EW, Kawagishi H, Tomoda H. Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages. Biol Pharm Bull 2006 29 : 981 4.
36. Kim JH, Jeong JH, Jeon ST, Kim H, Ock J, Suk K, et al. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol Pharmacol 2006 69 : 1783 90.
37. Kim HH, Sik Bang S, Seok Choi J, Han H, Kim IH. Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. Cancer Lett 2005 223 : 191 201.
38. Yim D, Singh R P, Agarwal C, Lee S, Chi H, Agarwal R. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res 2005 65 : 1035 44.
39. Lee S, Lee YS, Jung SH, Shin KH, Kim BK, Kang SS. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res 2003 26 : 727 30.
40. Shin D, Kim H, Jang K, Kim H, Chung H, Kong G. The in vitro and in vivo anti-tumor effect of decursin in estrogen receptor-negative human breast cancer cells occurs via downregulation of Akt signaling pathway. [abstract]. In: American Association for Cancer Research Annual Meeting: Proceedings; 2007 Apr 14-18; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 447.