Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH)

Mutagenesis

Volumn 22, Issue 5, 2007, Pages 321-327

  Escobar, Patricia A ^a   Smith, Martyn T ^a   Vasishta, Ananth ^a   Hubbard, Alan E ^a   Zhang, Luoping ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; DNA; ETOPOSIDE; HYDROQUINONE; MELPHALAN;

ARTICLE; CHROMOSOME 11Q; CHROMOSOME 5Q; CHROMOSOME DAMAGE; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; LYMPHOBLASTOID CELL; PRIORITY JOURNAL;

ALKYLATING AGENTS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 5; COMET ASSAY; DNA DAMAGE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTES; MYELOID-LYMPHOID LEUKEMIA PROTEIN; TRANSLOCATION, GENETIC;

EID: 34548382525     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gem020     Document Type: Article

References (43)

1. Krivtsov, A. V., Twomey, D., Feng, Z. et al. (2006) Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature, 442, 818-822.
2. Taki, T. and Taniwaki, M. (2006) Chromosomal translocations in cancer and their relevance for therapy. Curr. Opin. Oncol., 18, 62-68.
3. Smith, M. T., Skibola, C. F., Allan, J. M. and Morgan, G. J. (2004) Causal models of leukaemia and lymphoma. IARC Sci. Publ., 157, 373-392.
4. Deschler, B. and Lubbert, M. (2006) Acute myeloid leukemia: epidemiology and etiology. Cancer, 107 (9), 2099-107.
5. Larson, R. A. and Le Beau, M. M. (2005) Therapy-related myeloid leukaemia: a model for leukemogenesis in humans. Chem. Biol. Interact., 153-154, 187-195.
6. Pedersen-Bjergaard, J. (2005) Insights into leukemogenesis from therapy-related leukemia. N. Engl. J. Med., 352, 1591-1594.
7. Felix, C. A. (2001) Leukemias related to treatment with DNA topoisomerase II inhibitors. Med. Pediatr. Oncol., 36, 525-535.
8. Mamuris, Z., Dumont, J., Dutrillaux, B. and Aurias, A. (1990) Specific chromosomal mutagenesis observed in stimulated lymphocytes from patients with S-ANLL. Int. J. Cancer, 46, 563-568.
9. Mamuris, Z., Gerbault-Seureau, M., Prieur, M., Pouillart, P., Dutrillaux, B. and Aurias, A. (1989) Chromosomal aberrations in lymphocytes of patients treated with melphalan. Int. J. Cancer, 43, 80-86.
10. Mamuris, Z., Prieur, M., Dutrillaux, B. and Aurias, A. (1989) The chemotherapeutic drug melphalan induces breakage of chromosomes regions rearranged in secondary leukemia. Cancer Genet. Cytogenet., 37, 65-77.
11. Amiel, A., Yukla, M., Yogev, S., Manor, Y., Fejgin, M. D. and Lishner, M. (2004) Deletion of 5q31 and 7q31 in patients with stable melphalan treated multiple myeloma. Cancer Genet. Cytogenet., 152, 84-87.
12. Felix, C. A., Kolaris, C. P. and Osheroff, N. (2006) Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst.), 5, 1093-1108.
13. Infante, P. F., Rinsky, R. A., Wagoner, J. K. and Young, R. J. (1977) Leukaemia in benzene workers. Lancet, 2, 76-78.
14. Rinsky, R. A., Hornung, R. W., Silver, S. R. and Tseng, C. Y. (2002) Benzene exposure and hematopoietic mortality: a long-term epidemiologic risk assessment. Am. J. Ind. Med., 42, 474-480.
15. Snyder, R. (2002) Benzene and leukemia. Crit. Rev. Toxicol., 32, 155-210.
16. Smith, M. T., Yager, J. W., Steinmetz, K. L. and Eastmond, D. A. (1989) Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity. Environ. Health Perspect., 82, 23-29.
17. Smith, M. T. (1996) The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ. Health Perspect., 104 (Suppl. 6), 1219-1225.
18. Zhang, L., Eastmond, D. A. and Smith, M. T. (2002) The nature of chromosomal aberrations detected in humans exposed to benzene. Crit. Rev. Toxicol., 32, 1-42.
19. Zhang, L., Rothman, N., Wang, Y. et al. (1998) Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis, 19, 1955-1961.
20. Zhang, L., Wang, Y., Shang, N. and Smith, M. T. (1998) Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leuk. Res., 22, 105-113.
21. Eastmond, D. A., Mondrala, S. T. and Hasegawa, L. (2005) Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene. Chem. Biol. Interact., 153-154, 207-216.
22. Frantz, C. E., Chen, H. and Eastmond, D. A. (1996) Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites. Environ. Health Perspect., 104 (Suppl. 6), 1319-1323.
23. Singh, N. P., McCoy, M. T., Tice, R. R. and Schneider, E. L. (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
24. Tice, R. R., Agurell, E., Anderson, D. et al. (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen., 35, 206-221.
25. Collins, A. R. (2004) The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol., 26, 249-261.
26. Santos, S. J., Singh, N. P. and Natarajan, A. T. (1997) Fluorescence in situ hybridization with comets. Exp. Cell Res., 232, 407-411.
27. Rapp, A., Bock, C., Dittmar, H. and Greulich, K. O. (2000) UV-A breakage sensitivity of human chromosomes as measured by COMET-FISH depends on gene density and not on the chromosome size. J. Photochem. Photobiol. B, 56, 109-117.
28. McKelvey-Martin, V. J., Ho, E. T., McKeown, S. R., Johnston, S. R., McCarthy, P. J., Rajab, N. F. and Downes, C. S. (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells. Mutagenesis, 13, 1-8.
29. McKenna, D. J., Rajab, N. F., McKeown, S. R., McKerr, G. and McKelvey-Martin, V. J. (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. Radiat. Res., 159, 49-56.
30. Schaeferhenrich, A., Sendt, W., Scheele, J., Kuechler, A., Liehr, T., Claussen, U., Rapp, A., Greulich, K. O. and Pool-Zobel, B. L. (2003) Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. Food Chem. Toxicol., 41, 655-664.
31. Horvathova, E., Dusinska, M., Shaposhnikov, S. and Collins, A. R. (2004) DNA damage and repair measured in different genomic regions using the comet assay with fluorescent in situ hybridization. Mutagenesis, 19, 269-276.
32. Kumaravel, T. S. and Bristow, R. G. (2005) Detection of genetic instability at HER-2/neu and p53 loci in breast cancer cells sing Comet-FISH. Breast Cancer Res. Treat., 91, 89-93.
33. Stillman, W. S., Varella-Garcia, M. and Irons, R. D. (2000) The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells. Exp. Hematol., 28, 169-176.
34. Amendola, R., Basso, E., Pacifici, P. G., Piras, E., Giovanetti, A., Volpato, C. and Romeo, G. (2006) Ret, Abl1 (cAbl) and Trp53 gene fragmentations in comet-FISH assay act as in vivo biomarkers of radiation exposure in C57BL/6 and CBA/J mice. Radiat. Res., 165, 553-561.
35. McCullagh, P. and Nelder, J. (1989) Generalized Linear Models. CRC Press, London.
36. Zeger, S. L. and Liang, K. Y. (1986) Longitudinal data analysis for discrete and continuous outcomes. Biometrics, 42, 121-130.
37. Hovhannisyan, G., Rapp, A., Arutyunyan, R., Greulich, K. O. and Gebhart, E. (2005) Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells. Int. J. Mol. Med., 15, 437-442.
38. Arutyunyan, R., Rapp, A., Greulich, K. O., Hovhannisyan, G., Haroutiunian, S. and Gebhart, E. (2005) Fragility of telomeres after bleomycin and cisplatin combined treatment measured in human leukocytes with the Comet-FISH technique. Exp. Oncol., 27, 38-42.
39. Knobel, Y., Glei, M., Weise, A., Osswald, K., Schaferhenrich, A., Richter, K. K., Claussen, U. and Pool-Zobel, B. L. (2006) Uranyl nitrilotriacetate, a stabilized salt of uranium, is genotoxic in nontransformed human colon cells and in the human colon adenoma cell line LT97. Toxicol. Sci., 93, 286-297.
40. Harreus, U. A., Kleinsasser, N. H., Zieger, S., Wallner, B., Reiter, M., Schuller, P. and Berghaus, A. (2004) Sensitivity to DNA-damage induction and chromosomal alterations in mucosa cells from patients with and without cancer of the oropharynx detected by a combination of comet assay and fluorescence in situ hybridization. Mutat. Res., 563, 131-138.
41. Ng, A., Taylor, G. M. and Eden, O. B. (2006) Genotoxicity of etoposide: greater susceptibility of MLL than other target genes. Cancer Genet. Cytogenet., 164, 164-167.
42. Whysner, J., Reddy, M. V., Ross, P. M., Mohan, M. and Lax, E. A. (2004) Genotoxicity of benzene and its metabolites. Mutat. Res., 566, 99-130.
43. Irons, R. D. and Stillman, W. S. (1996) The process of leukemogenesis. Environ. Health Perspect., 104 (Suppl. 6), 1239-1246.