Neuroimaging of epilepsy: Therapeutic implications

NeuroRx

Volumn 2, Issue 2, 2005, Pages 384-393

  Kuzniecky, Ruben I ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Epilepsy; Functional MRI; Magnetoencephalography; MR spectroscopy; MRI; PET; SPECT

Indexed keywords

COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ELECTROMAGNETIC RADIATION; EPILEPSY; HUMAN; MAGNETOENCEPHALOGRAPHY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; REVIEW; SCINTISCANNING; SEIZURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 16344381136     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1602/neurorx.2.2.384     Document Type: Article

References (86)

1. Hauser W. Epilepsy: frequency, causes and consequences. New York: Demos Press, 1990.
2. Bammer R, Skare S, Newbould R, Liu C, Thijs V, Ropele S, Clayton DB, Krueger G, Moseley ME, Glover GH. Foundations of advanced magnetic resonance imaging. NeuroRx 2:167-196, 2005.
3. Bronen RA, Fulbright RK, Spencer SS, Spencer DD, Kim JH, Lange RC. Economic impact of replacing CT with MR imaging for refractory epilepsy. Magn Reson Imaging 15:857-862, 1997.
4. Sá de Camargo EC, Koroshetz WJ. Neuroimaging of ischemia and infarction. NeuroRx 2:265-276, 2005.
5. Hankey G, Davies L, Gubbay SS. Long term survival with early childhood intracerebral tumours. J Neurol Neurosurg Psychiatry 52:778-781, 1989.
6. Wyllie E, Rothner AD, Luders H. Partial seizures in children: clinical features, medical treatment, and surgical considerations. Pediatr Clin North Am 36:343-364, 1989.
7. Gastaut H, Gastaut JL. Computerized transverse axial tomography in epilepsy. Epilepsia 17:325-336, 1976.
8. Earnest M, Feldman H, Marx J, Harris J, Biletch M, Sullivan E: Intracranial lesions shown by CT scans in 259 first alcohol related seizures. Neurology 38:1561-1565, 1988.
9. Mathieson G. Pathology of temporal lobe foci. In: Complex partial seizures and their treatment (Penry JK, Daly DD, eds), pp 163-185. New York: Raven Press, 1975.
10. Kuzniecky R, Murro A, King D, Morawetz R, Smith J, Powers R, et al. Magnetic resonance imaging in childhood intractable partial epilepsies: pathologic correlations. Neurology 43:681-687, 1993.
11. Kuzniecky R. Magnetic resonance imaging in developmental disorders of the cerebral cortex. Epilepsia 35:S44-S56, 1994.
12. Kuzniecky R, Garcia JH, Faught E, Morawetz RB. Cortical dysplasia in TLE: MRI correlations. Ann Neurol 29:293-298, 1991.
13. Babb TL, Pretorius JK. Pathological substrates of epilepsy. In: The treatment of epilepsy: principles and practice (Wylie E, ed), pp 55-70. Philadelphia: Lea & Febiger, 1993.
14. Cascino GD, Jack CR Jr, Parisi JE, Sharbrough FW, Hirschorn KA, Meyer FB, et al. Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: pathological correlations. Ann Neurol 30:31-36, 1991.
15. Cendes F, Andermann F, Gloor P, Evans A, Jones-Gotman M, Watson C, et al. MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology 43:719-725, 1993.
16. Kuzniecky R, de la Sayette V, Ethier R, Melanson D, Andermann F, Berkovic S, et al. Magnetic resonance imaging in temporal lobe epilepsy: pathological correlations. Ann Neurol 22:341-347, 1987.
17. Jack C. MRI-based hippocampal volume measuremnts in epilepsy. Epilepsia 35:14-19, 1994.
18. Barkovich A, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB. Classification system for malformations of cortical development: Update 2001. Neurology 57:2168-2178, 2001.
19. Berg AT, Shinnar S. The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology 41:965-972, 1991.
20. Kobayashi E, D'Agostino MD, Lopes-Cendes I, Berkovic SF, Li ML, Andermann E, et al. Hippocampal atrophy and T2-weighted signal changes in familial mesial temporal lobe epilepsy. Neurology 60:405-409, 2003.
21. Scott RC, Gadian DG, King MD, Chong WK, Cox TC, Neville BG, et al. Magnetic resonance imaging findings within 5 days of status epilepticus in childhood. Brain 125:1951-1959, 2002.
22. Semah F, Lamy C, Demeret S. Hippocampal sclerosis and other hippocampal abnormalities in the early identification of candidates for epilepsy surgery. Arch Neurol 59:1042-1043, 2002.
23. Kuzniecky R, Burgard S, Faught E, Morawetz R, Bartolucci A. Predictive value of magnetic resonance imaging in temporal lobe epilepsy surgery. Arch Neurol 50:65-69, 1993.
24. Berkovic SF, McIntosh AM, Kalnins RM, Jackson GD, Fabinyi GC, Brazenor GA, et al. Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis. Neurology 45:1358-1363, 1995.
25. Paglioli E, Palmini A, Paglioli E, da Costa JC, Portuguez M, Martinez JV, et al. Survival analysis of the surgical outcome of temporal lobe epilepsy due to hippocampal sclerosis. Epilepsia 45:1383-1391, 2004.
26. Pilz DT, Matsumoto N, Minnerath S, Mills P, Gleeson JG, Allen KM, W, et al. LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation. Hum Mol Genet 7:2029-2037, 1998.
27. Devous MD Sr. Single-photon emission computed tomography in neurotherapeutics. NeuroRx 2:237-249, 2005.
28. Horsely V. An address on the origin and seat of epileptic disturbance. Br Med J 1:693-696, 1892.
29. Krausz Y, Cohen D, Konstantini S, Meiner Z, Yaffe S, Atlan H. Brain SPECT imaging in temporal lobe epilepsy. Neuroradiology 33:274-276, 1991.
30. O'Brien TJ. SPECT: methodology. Adv Neurol 83:11-32, 2000.
31. Laich E, Kuzniecky R, Mountz J, Liu HG, Gilliam F, Bebin M, et al. Supplementary sensorimotor area epilepsy: seizure localization, cortical propagation and subcortical activation pathways using ictal SPECT. Brain 120:855-864, 1997.
32. Harvey A, Hopkins IJ, Bowe JM, Cook DJ, Shield LK, Berkovic SF. Frontal lobe epilepsy: clinical seizure characteristics and localization with ictal 99mTc-HMPAO SPECT. Neurology 43:1966-1980, 1993.
33. Marks DA, Katz A, Hoffer P, Spencer SS. Localization of extratemporal epileptic foci during ictal single photon emission computed tomography. Ann Neurol 31:250-255, 1992.
34. O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Bohnen NI, et al. Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus. Neurology 50:445-454, 1998.
35. Spanaki MV, Spencer SS, Corsi M, MacMullan J, Seibyl J, Zubal IG. Sensitivity and specificity of quantitative difference SPECT analysis in seizure localization. J Nucl Med 40:730-736, 1999.
36. Zubal IG, Spencer SS, Imam K, Seibyl J, Smith EO, Wisniewski G, Hoffer PB. Difference images calculated from ictal and interictal technetium-99m-HMPAO SPECT scans of epilepsy. J Nucl Med 36:684-689, 1995.
37. Brooks DJ. Positron emission tomography and single-photon emission computed tomography in central nervous system drug development. NeuroRx 2:226-236, 2005.
38. Chugani DC, Chugani HT. New directions in PET neuroimaging for neocortical epilepsy. Adv Neurol 84:447-456, 2000.
39. Engel JJ, Brown WJ, Kuhl DE, Phelps ME, Mazziotta JC, Crandall PH. Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy. Ann Neurol 12:518-528, 1982.
40. Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner TJ, et al. α-Methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 60:960-968, 2003.
41. Fedi M, Reutens D, Okazawa H, Andermann F, Boling W, Dubeau F, et al. Localizing value of α-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin. Neurology 57:1629-1636, 2001.
42. Koepp MJ, Hammers A, Labbe C, Woermann FG, Brooks DJ, Duncan JS. 11C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI. Neurology 54:332-339, 2000.
43. Madar I, Lesser RP, Krauss G, Zubieta JK, Lever JR, Kinter CM, et al. Imaging of δ- and μ-opioid receptors in temporal lobe epilepsy by positron emission tomography. Ann Neurol 41:358-367, 1997.
44. Lin A, Ross BD, Harris K, Wong W. Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx 2:197-214, 2005.
45. Kuzniecky R, Elgavish GA, Hetherington HP, Evanochko WT, Pohost GM. In vivo 31P nuclear magnetic resonance spectroscopy of human temporal lobe epilepsy. Neurology. 42:1586-1590, 1992.
46. Cendes F, Andermann F, Preul PC, Arnold DL. Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton MRS. Ann Neurol 35:211-216, 1994.
47. Hetherington H, Kuzniecky R, Pan J, Mason G, Morawetz R, Harris C, et al. Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy. Ann Neurol 38:396-404, 1995.
48. Hugg JW, Laxer KD, Matson GB, Maudsley AA, Weiner MW. Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol 34:788-794, 1993.
49. Li LM, Caramanos Z, Cendes F, Andermann F, Antel SB, Dubeau F, et al. Lateralization of temporal lobe epilepsy (TLE) and discrimination of TLE from extra-TLE using pattern analysis of magnetic resonance spectroscopic and volumetric data. Epilepsia 41:832-842, 2000.
50. Maton BM, Kuzniecky RI. Proton MRS: N-acetyl aspartate, creatine, and choline. Adv Neurol 83:253-259, 2000.
51. Cendes F, Stanley J, Dubeau F, Anderamnn F, Arnold DL. MR spectroscopy differentiates lactate in complex partial versus absence seizures. Ann Neurol 41:74-81, 1997.
52. Cendes F, Caramanos Z, Andermann F, Dubeau F, Arnold D. Proton MRSI and MRI volumetry in the lateralization of temporal lobe epilepsy: a series of 100 patients. Ann Neurol 42:737-746, 1997.
53. 1H spectroscopic imaging and hippocampal volumetry in the lateralization of mesial temporal lobe epilepsy. Neurology 51:66-71, 1998.
54. Bernasconi A, Tasch E, Cendes F, Li LM, Arnold DL. Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy. Prog Brain Res 135:297-304, 2002
55. 1H magnetic resonance spectroscopic imaging. Ann Neurol 40:236-239, 1996.
56. Petroff OA. GABA and glutamate in the human brain. Neuroscientist 8:562-573, 2002.
57. 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain. Epilepsia 36:457-464, 1995.
58. Petroff OA, Rothman DL, Behar KL, Hyder F, Mattson RH. Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures. Seizure 8:120-127, 1999.
59. Petroff OA, Mattson RH, Rothman DL. Proton MRS: GABA and glutamate. Adv Neurol 83:261-271, 2000.
60. 1H NMR measurements of γ-aminobutyric acid in human brain in vivo. Proc Natl Acad Sci USA 90:5662-5666, 1993.
61. 1H NMR measurements of 2-pyrrolidinone in human brain in vivo. Magn Reson Med 41:889-896, 1999.
62. Shen J, Rothman DL, Brown P. In vivo GABA editing using a novel doubly selective multiple quantum filter. Magn Reson Med 47:447-454, 2002.
63. Hanstock CC, Coupland NJ, Allen PS. GABA X2 multiplet measured pre- and post-administration of vigabatrin in human brain. Magn Reson Med 48:617-623, 2002.
64. Terpstra M, Ugurbil K, Gruetter R. Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla. Magn Reson Med 47:1009-1012, 2002.
65. Menini C, Silva-Barrat C. The photosensitive epilepsy of the baboon. A model of generalized reflex epilepsy. Adv Neurol 75:29-47, 1998.
66. Lloyd KG, Scatton B, Voltz C, Bryere P, Valin A, Naquet R. Cerebrospinal fluid amino acid and monoamine metabolite levels of Papio papio: correlation with photosensitivity. Brain Res 363:390-394, 1986.
67. Kasteleijn-Nolst Trenite DG. Reflex seizures induced by intermittent light stimulation. Adv Neurol 75:99-121, 1998.
68. Rimmer EM, Milligan NM, Richens A. A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients. Epilepsy Res 1:339-346, 1987.
69. Petroff OA, Behar KL, Rothman DL. New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures. Adv Neurol 79:939-945, 1999.
70. Petroff OA, Hyder F, Rothman DL, Mattson RH. Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients. Epilepsia 41:675-680, 2000.
71. Petroff OA, Hyder F, Rothman DL, Mattson RH. Topiramate rapidly raises brain GABA in epilepsy patients. Epilepsia 42:543-548, 2001.
72. Kuzniecky R, Ho S, Pan J, Martin R, Gilliam F, Faught E, et al. Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults. Neurology 58:368-372, 2002.
73. Errante LD, Williamson A, Spencer DD, Petroff OA. Gabapentin and vigabatrin increase GABA in the human neocortical slice. Epilepsy Res 49:203-210, 2002.
74. Kuzniecky R, Hetherington H, Ho S, Pan J, Martin R, Gilliam F, et al. Topiramate increases cerebral GABA in healthy humans. Neurology 51:621-629, 1998.
75. Petroff OA, Hyder F, Collins T, Mattson RH, Rothman DL. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. Epilepsia 40:958-964, 1999.
76. Detre JA, Sirven JI, Alsop DC, O'Connor MJ, French JA. Localization of subclinical ictal activity by functional magnetic resonance imaging: correlation with invasive monitoring. Ann Neurol 38:618-624, 1995.
77. Detre JA, Floyd TF. Functional MRI and its applications to the clinical neurosciences. Neuroscientist 7:64-79, 2001.
78. Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, et al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 46:978-984, 1996.
79. Sabbah P, Chassoux F, Leveque C, Landre E, Baudoin-Chial S, Devaux B, et al. Functional MR imaging in assessment of language dominance in epileptic patients. Neuroimage 18:460-467, 2003.
80. Rutten GJ, Ramsey NF, van Rijen PC, Alpherts WC, van Veelen CW. FMRI-determined language lateralization in patients with unilateral or mixed language dominance according to the Wada test. Neuroimage 17:447-460, 2002.
81. Gao X, Jiang C, Lu C, Shen T. Determination of the dominant language hemisphere by functional MRI in patients with temporal lobe epilepsy. Chin Med J (Engl) 114:711-713, 2001.
82. Gallen CC, Hirschkoff EC, Buchanan DS. Magnetoencephalography and magnetic source imaging. Capabilities and limitations. Neuroimaging Clin N Am 5:227-249, 1995.
83. Ricci GB, Romani GL, Salustri C, Pizzella V, Torrioli G, Buonomo S, et al. Study of focal epilepsy by multichannel neuromagnetic measurements. Electroencephalogr Clin Neurophysiol 66:358-368, 1987.
84. Ebersole JS. Magnetoencephalography/magnetic source imaging in the assessment of patients with epilepsy. Epilepsia 38:S1-S5, 1997.
85. Stefan H, Hummel C, Scheler G, Genow A, druschky K, Tilz C, et al. Magnetic brain source imaging of focal epileptic activity: a synopsis of 455 cases. Brain 126:2396-2405, 2003.
86. Genow A, Hummel C, Scheler G, Hopfengartner R, Kaltenhauser M, Buchfelder M, et al. Epilepsy surgery, resection volume and MSI localization in lesional frontal lobe epilepsy. Neuroimage 21:444-449, 2004.