SERPINB11 is a new noninhibitory intracellular serpin: Common single nucleotide polymorphisms in the scaffold impair conformational change

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 24948-24960

  Askew, David J ^a   Cataltepe, Sule ^b   Kumar, Vasantha ^b,e   Edwards, Christopher ^a   Pace, Serena M ^a   Howarth, Rica N ^a   Pak, Stephen C ^a   Askew, Yuko S ^a   Brömme, Dieter ^c   Luke, Cliff J ^a   Whisstock, James C ^d   Silverman, Gary A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d MONASH UNIVERSITY   (Australia)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; MAMMALS; POLYMORPHISM; PROTEINS;

HUMAN RSL; INHIBITORY ACTIVITY; REACTIVE SITE LOOP (RSL); SINGLE NUCLEOTIDE POLYMORPHISMS (SNP);

NUCLEOTIDES;

PEPTIDASE; SCAFFOLD PROTEIN; SERINE PROTEINASE INHIBITOR; SERPINB1 1; TRYPSIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

ALLELE; ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CLADISTICS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE EXPRESSION; HAPLOTYPE; HUMAN; HUMAN TISSUE; MUTAGENESIS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 34548349300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703182200     Document Type: Article

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