Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: A critical role for the P3' proline in facilitating RSL cleavage

Biochemistry

Volumn 39, Issue 24, 2000, Pages 7081-7091

  Luke, Cliff ^a   Schick, Charles ^a   Tsu, Christopher ^a   Whisstock, James C ^b   Irving, James A ^b   Brömme, Dieter ^c   Juliano, Luiz ^d   Shi, Guo Ping ^e   Chapman, Harold A ^e   Silverman, Gary A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MONASH UNIVERSITY   (Australia)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CHYMASE; CYSTEINE PROTEINASE INHIBITOR; PAPAIN; PROLINE; PROTEINASE; SERINE PROTEINASE INHIBITOR; SQUAMOUS CELL CARCINOMA ANTIGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; MOLECULAR MODEL; MOLECULAR WEIGHT; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MODIFICATION; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; BINDING SITES; CATHEPSINS; ELASTIN; ENZYME STABILITY; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PAPAIN; PEPTIDE FRAGMENTS; PROLINE; SEQUENCE ALIGNMENT; SERPINS;

EID: 0034691279     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000050g     Document Type: Article

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