Reciprocal effects of ascorbate on cancer cell growth and the expression of matrix metalloproteinases and transforming growth factor-β

Cancer Letters

Volumn 256, Issue 1, 2007, Pages 49-55

  Philips, Neena ^a,b   Keller, Thomas ^a,b   Holmes, Carol ^a,b  

^a GEORGIAN COURT UNIVERSITY   (United States)

^b FAIRLEIGH DICKINSON UNIVERSITY   (United States)

Author keywords

Cancer; Matrix metalloproteinases; Transforming growth factor ; Viability; Vitamin C

Indexed keywords

ASCORBIC ACID; GELATINASE A; INTERSTITIAL COLLAGENASE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ANTIOXIDANTS; ASCORBIC ACID; BREAST NEOPLASMS; CELL SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HUMANS; KIDNEY NEOPLASMS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MELANOMA; RNA, MESSENGER; SKIN NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED;

EID: 34548348730     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.05.009     Document Type: Article

References (39)

1. Kao R.T., and Stern R. Collagenases in human breast carcinoma cell lines. Cancer Res. 46 (1986) 1349-1354
2. Westermarck J., and Kahari V.M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 12 (1999) 781-792
3. Cox G., and O'Byrne K.J. Matrix metalloproteinases and cancer. Anticancer Res. 21 (2001) 4207-4220
4. Mauviel A., Chung K.Y., Agarwal A., Tamai K., and Uitto J. Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes. J. Biol. Chem. 271 (1996) 10917-10923
5. Philips N., Keller T., and Gonzalez S. TGF-β like regulation of matrix mettalloproteinases by anti transforming growth factor-β and anti transforming growth factor-β1 antibodies in dermal fibroblasts: implications to wound healing. Wound Rep. Reg. 12 (2004) 53-59
6. Chen S.J., Yuan W., Mori Y., Levenson A., Trojanowaska M., and Varga J. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: involvement of Smad 3. J. Invest. Dermatol. 112 (1999) 49-57
7. Merryman J.I., Neilsen N., and Staton D.D. Transforming growth factor-beta enhances the ultraviolet-mediated stress response in p53-/- keratinocytes. Int. J. Oncol. 13 (1998) 781-789
8. Philips N., and Onwubalili N. Anti transforming growth factor-beta (TGF-β) increases the expressions of matrix metalloproteinase-1 (MMP-1) and growth factors in a renal adenocarcinoma cell line. Bios 73 (2002) 86-90
9. Philips N., and McFadden K. Inhibition of transforming growth factor-beta and matrix metalloproteinases by estrogen, and prolactin in breast cancer cells. Cancer Lett. 206 (2004) 63-68
10. Philips N. An anti TGF-β increased the expression of transforming growth factor-β, matrix metalloproteinase-1 and elastin, and its effects were antagonized by ultraviolet radiation in epidermal keratinocytes. J. Dermatol. Sci. 33 (2003) 177-179
11. Tsao C.S. Inhibiting effect of ascorbic acid on the growth of human mammary tumor xenografts. Am. J. Clin. Nutr. 45 (1991) 1274S-1280S
12. Liehr J.G., and Wheeler W.J. Inhibition of estrogen-induced renal carcinoma in Syrian hamsters by vitamin C. Cancer Res. 43 (1983) 4638-4642
13. Oliveira C.P., Kassab P., Lopasso F.P., Souza H.P., Janiszewski M., Laurindo F.R., and Iriya K. Laudanna, protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress. World J. Gasteroenterol. 9 (2003) 446-448
14. Lutsenko E., Carcamo J., and Golde D. Vitamin C prevents DNA mutation induced by oxidative stress. J. Biol. Chem. 277 (2002) 16895-16899
15. Potdar P., Kandarkar S., and Sirsat S. Modulation by Vitamin C of tumor incidence and inhibition in oral carcinogenesis. Funct. Dev. Morphol. 3 (1992) 167-172
16. Liu J., Nagao N., Kageyama K., and Miwa N. Antimetastatic and anti-invasive ability of phospho-asorbyl palmitated through intracellular ascorbate enrichment and the resultant antioxidant action. Oncol. Res. 11 (1999) 479-487
17. Cohen S.M., Anderson T.A., Oliveria L.M., and Arnold L.L. Tumorigenicity of sodium ascorbate in male rats. Cancer Res. 58 (1998) 2557-2561
18. Murai T., Mori S., Hosono M., Takashima A., Machino S., Oohara T., Yamashita H., Makino S., Matsuda T., Wanibuchi H., and Fukushima S. Strain differences in sensitivity to the promoting effects of sodium l-ascorbate in a two-stage rat urinary bladder carcinogenesis model. Jpn. J. Cancer Res. 88 (1997) 245-253
19. Schwartz J., Shklar G., and Triclker D. Vitamin C enhances the development of carcinomas in the hamster buccal pouch experimental model. Oral Surg. Med. Oral Pathol. 76 (1993) 718-722
20. Hidvegi M., Raso E., Omoskozi-Farkas R., Sandor P., Lapis K., and Szende B. Effects of avemar and avemar + vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res. 18 (1998) 2353-2358
21. Moertel C.G., Fleming T.R., Creagan E.T., Rubin J., O'Connell M.J., and Ames M.M. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N. Engl. J. Med. 312 (1985) 137-141
22. Creagan E.T. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer: a controlled trial. N. Engl. J. Med. 301 (1979) 687-690
23. Noto V., Henryk S., Taper S., Jiang Y.H., Jannsens J., Bonte J., and De Loecker W. Effects of sodium ascorbate (Vitamin C) and 2-methyl-1,4-naphthoquinone (Vitamin K) treatment on human tumor cell in vitro. I. Synergism of combined vitamin C and K action. Cancer 63 (1989) 901-906
24. De Loecker W., Janssens J., Bonte J., and Taper H. Effects of sodium ascorbate (Vitamin C) and 2-methyl-1,4-naphthoquinone (Vitamin k) treatment on human tumor cell growth in-vivo. II. Synergism with combined chemotherapy action. Anticancer Res. 13 (1993) 103-106
25. Chen Q., Espey M.G., Krishna M.C., Mitchell J.B., Corpe C.P., Buettner G.R., Shacter E., and Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc. Natl. Acad. Sci. USA 102 (2005) 13604-13609
26. Clement M., Ramalingam J., Long L., and Halliwell B. The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid. Redox. Signal. 3 (2001) 157-163
27. Davies K.J.A. The Broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. Life 48 (1999) 41-47
28. Agus D., Vera J., and Golde D. Stromal cell oxidation. Cancer Res. 59 (1999) 4555-4558
29. Spielholz C., Golde D.W., Houghton A.N., Nualart F., and Vera J.C. Increased transport of dehydroascorbic acid without changes in sodium dependent ascorbate transport in human melanoma cells. Cancer Res. 57 (1997) 2529-2537
30. Philips N., Burchill D., O'Donoghue D., Keller T., and Gonzalez S. Identification of benzene metabolites in dermal fibroblasts: Regulation of cell viability, apoptosis, lipid peroxidation, and expression of MMP-1 and elastin by benzene metabolites. Skin Pharmacol. Physiol. 17 (2004) 147-152
31. Nelson K.K., Ranganathan A.C., Mansouri J., Rodriguez A.M., Providence K.M., Rutter J.L., Pumiglia K., Bennett J.A., and Melendez J.A. Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis. Clin. Cancer Res. 9 (2003) 424-432
32. Nelson K.K., Subbaram S., Connor K.M., Dasgupta J., Ha X.F., Meng T.C., Tonks N.K., and Melendez J.A. Redox- dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. J. Biol. Chem. 281 (2006) 14100-14110
33. Roomi M.W., Ivanov V., Niedzwiecki A., and Rath M. In vitro and in vivo antitumor effect of ascorbic acid, lysine, proline, and green extract on human melanoma cell line A2058. In Vivo 20 (2006) 25-32
34. Head K.A. Ascorbic acid in the prevention and treatment of cancer. Altern. Med. Rev. 3 (1998) 174-186
35. Philips N., and Devaney J. Beneficial regulation of type I collagen and matrixmetalloproteinase-1 expression by estrogen, progesterone, and its combination in skin fibroblasts. J. Am. Aging Assoc. 26 (2003) 59-62
36. Frazier K., Williams S., Kothapalli D., Klapper H., and Grotendorst G.R. Stimulation of fibroblast cell growth, matrix production, granulation tissue formation by connective tissue growth factor. J. Invest. Dermatol. 107 (1996) 404-411
37. Booth B., and Uitto J. The effects of ascorbic acid on procollagen production and prolyl-hydorxylase activity. Biochem. Biophys. 675 (1981) 117-122
38. Greesin J., Murad S., and Pinnell S. Ascorbic acid stimulates collagen production without altering intracellular degradation in cultured human skin fibroblasts. Biochem. Biophys. 866 (1985) 272-274
39. Roomi M.W., Roomi N., Ivanov V., Kalinovsky T., Niedzwiecki A., and Rath M. Inhibitory effect of a mixture containing ascorbic acid, lysine, proline, and green tea extract on critical parameters in angiogenesis. Oncol. Rep. 14 (2005) 807-815