Antimetastatic and anti-invasive ability of phospho-ascorbyl palmitate through intracellular ascorbate enrichment and the resultant antioxidant action

Oncology Research

Volumn 11, Issue 10, 1999, Pages 479-487

  Liu, Jian Wen ^a   Nagao, Norio ^a   Kageyama, Katsuhiro ^b   Miwa, Nobuhiko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ascorbic acid; Cytotoxicity; Invasion; Matrix metalloprotease; Metastasis; Reactive oxygen species

Indexed keywords

6 O PALMITOL ASCORBATE 2 O PHOSPHATE; 6-O-PALMITOL-ASCORBATE-2-O-PHOSPHATE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; DRUG DERIVATIVE; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; C57BL MOUSE; CANCER INVASION; CANCER TRANSPLANTATION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; METASTASIS; MOUSE; OXIDATIVE STRESS; TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033291347     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Miwa, N.; Yamazaki, H.; Ikari, Y. Enhancement of ascorbate cytotoxicity by chelation with ferrous ions through prolonged duration of the action. Anticancer Res. 6:1033-1036; 1986.
2. Miwa, N.; Yamazaki, H. Potentiated susceptibility of ascites tumor to acyl derivatives of ascorbate caused by balanced hydrophobicity in the molecule. Exp. Cell Biol. 54:245-294; 1986.
3. Hidvegi, M.; Raso, E.; Tomoskozi-Farkas, R.; Paku, S.; Lapis, K.; Szende, B. Effect of avemar and avemar + vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res. 18:2353-2358; 1998.
4. Fuchs, J.; Kern, H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: A clinical study using solar simulated radiation. Free Radic. Biol. Med. 25: 1006-1012; 1998.
5. Wilson, J. X.; Dixon, S. J.; Yu, J.; Nees, S.; Tyml, K. Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle. Microcirculation 3:211-221; 1996.
6. Kiyatkin, E. A.; Rebec, G. V. Ascorbate modulates glutamate-induced excitations of striatal neurons. Brain Res. 812:14-22; 1998.
7. Shinriki, N.; Suzuki, T.; Takama, K.; Fukunaga, K.; Ohgiya, S.; Kubota, K.; Miura, T. Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone. Hematology (Budapest) 29:229-239; 1998.
8. Furumoto, K.; Inoue, E.; Nagao, N.; Hiyama, E.; Miwa, N. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 63:935-948; 1998.
9. Cameron, E.; Pauling, L.; Leibovitz, B. Ascorbic acid and cancer: A review. Cancer Res. 39:663-681; 1979.
10. Kon, W. S.; Lee, S. A.; Lee, H. A.; Park, C. H. Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines. Anticancer Res. 18:2487-2494; 1998.
11. Albini, A.; Iwamoto, Y.; Kleinman, H. K.; Martin, G. R.; Aaronson, S. A.; Kozlowski, J. M.; Mcewan, R. N. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 47:3239-3245; 1987.
12. Sejda, P.; Parce, J. W.; Seeds, M. S.; Bass, D. A. Flow cytometric quantitation of oxidative produce formation by polymorphonuclear leukocytes during phagocytosis. J. Immunol. 133:3303-3307; 1984.
13. Liu, J. W.; Nagao, N.; Kageyama, K.; Miwa, N. Anti-metastatic effect of an autooxidation-resistant and lipophilic ascorbic acid derivative through inhibition of tumor invasion. Anticancer Res. (in press).
14. Ballin, M.; Gomez, D. E.; Sinha, C. C.; Thorgeirsson, U. P. Ras oncogene mediated induction of a 92 kDa metalloproteinase: Strong correlation with the malignant phenotype. Biochem. Biophys. Res. Commun. 154:832-838; 1988.
15. Saiki, I.; Iida, J.; Murata, J.; Ogawa, R.; Nishi, N.; Sugimura, K.; Tokura, S.; Azuma, I. Inhibition of metastasis of murine malignant melanoma by synthetic polymeric peptides containing core sequences of cell-adhesive molecules. Cancer Res. 49:3815-3822; 1989.
16. Szatrowski, T. P.; Nathan, C. F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:794-798; 1991.
17. Nonaka, Y.; Iwagaki, H.; Kimura, T,; Fuchimoto, S.; Orita, K. Effect of reactive oxygen intermediates on the in vitro invasive capacity of tumor cells and liver metastasis in mice. Inc. J. Cancer 54:983-986; 1993.
18. Hata, R.; Senoo, H. L-Ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissue like substance by skin fibroblasts. J. Cell Physiol. 138:8-16; 1989.
19. Torii, Y.; Hitomi, K.; Tsukagoshi, N. L-Ascorbic acid 2-phosphate promotes osteoblastic differentiation of MC3T3-E1 mediated by accumulation of type I collagen. J. Nutr. Sci. Vitaminol. 40:229-238; 1994.
20. Miwa, N.; Yamazaki, H.; Nagaoka, Y.; Kageyama, K.; Onoyama, Y; Iaso, M-Y.; Otani, S.; Morisawa, S. Altered production of the active oxygen species is involved in enhanced cytotoxic action of acylated derivatives of ascorbate to tumor cells. Biochim. Biophys. Acta 972:144-151; 1988.
21. Kagayama, K.; Onoyama, Y.; Kimura, M.; Yamazaki, H.; Miwa, N. Enhanced inhibition of DNA synthesis and release of membrane phospholipids in tumor cells treated with a combination of acylated ascorbate and hyperthermia. Int. J. Hyperthermia 7:85-91; 1991.
22. Kawaguchi, Y.; Tanaka, H.; Okada, T.; Konishi, H.; Takahashi, M.; Ito, M.; Asai, J. The effects of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts. Arch. Dermatol. Res. 288:39-44; 1996.
23. Burkhardt, H.; Hartmann, F.; Schwingel, M. L. Activation of latent collagenase from polymorphonuclear leukocytes by oxygen radicals. Enzyme 36:221-231; 1986.
24. Sorsa, T.; Konttinen, Y. T.; Lindy, O.; Ritchlin, C.; Saari, U.; Suomalainen, K.; Eklund, K. K.; Santavirta, S. Collagenase in synovitis of rheumatoid arthritis. Semin. Arthritis Rheum. 22:44-53; 1992.
25. Crawford, D.; Zbinden, I.; Amstad, P.; Cerutti, P. Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 3:27-32; 1988.
26. Freije, J. M.; MacDonald, N. J., Steeg, P. S. Nm23 and tumour metastasis: Basic and translational advances. Biochem. Soc. Symp. 63:261-267; 1998.