Transforming growth factor-β1 enhances the ultravioletmediated stress response in p53-/- keratinocytes

International Journal of Oncology

Volumn 13, Issue 4, 1998, Pages 781-789

  Merryman, Joyce I ^a   Neilsen, Nancy ^a   Stanton, Diana D ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

c Jun amino terminal kinase; Keratinocytes; TGF 1; UVC

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROMOTER REGION; RADIATION EXPOSURE; REPORTER GENE; SKIN CANCER; SKIN CARCINOGENESIS; STRESS; ULTRAVIOLET IRRADIATION;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; GENE EXPRESSION; GENES, P53; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; MYELIN BASIC PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; ULTRAVIOLET RAYS;

EID: 0031712206     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Kraemer KH: Sunlight and skin cancer: another link revealed. Proc Natl Acad Sci USA 94: 11-14, 1997.
2. Crutzen PJ: Ultraviolet on the increase. Nature 356: 104-105, 1992.
3. Mai S, Stein B, van den Berg S, Kaina B, Lucke-Huhle C, Ponta H, Rahmsdorf HJ, Kraemer M, Gebel S and Herrlich P: Mechanisms of the ultraviolet light response in mammalian cells. J Cell Sci 94: 609-615, 1989.
4. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S and Leffell DJ: Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc 1: 136-142, 1996.
5. Jonason AS, Kunala S, Price GJ, Restifo RJ, Spinelli HM, Persing JA, Leffell DJ, Tarone RE and Brash DE: Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci USA 93: 14025-14029, 1996.
6. Karin M and Herrlich P: cis- and trans-acting genetic elements responsible for induction of specific genes by tumor promoters, serum factors, and stress. In: Genes and Signal Transduction in Multistage Carcinogenesis. Colburn NH (ed.) Marcel Dekker, Inc., New York, pp415-440, 1989.
7. Huang C, Ma W-Y, Bowden T and Dong Z: Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant-negative PKC γ/π. J Biol Chem 271: 31262-31268, 1996.
8. Kyriakis JM and Avruch J: Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271: 24313-24316, 1996.
9. Dérijard B, Hibi M, Wu I-H, Barrett T, Su B, Deng T, Karin M and Davis RJ: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain. Cell 76: 1025-1037, 1994.
10. Hibi M, Lin A, Smeal T, Minden A and Karin M: Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148, 1993.
11. 2-terminal kinases regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation. J Biol Chem 272: 10110-10116, 1997.
12. Chen Y-R, Wang X, Templeton D, Davis RJ and Tan T-H: The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J Biol Chem 271: 31929-31936, 1996.
13. Dhanwanda KR, Dickens M, Neades R, Davis R and Pelling JC: Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes. Oncogene 11: 1947-1953, 1995.
14. 2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. Cell Growth Differ 6: 1437-1446, 1995.
15. Devary Y, Gottlieh RA, Smeal T and Karin M: The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71: 1081-1091, 1992.
16. Warmuth I, Harth H, Matsui MS, Wang N and De Leo VA: Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res 54: 374-376, 1994.
17. Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrich P and Rahmsdorf HJ: Involvement of growth factor receptors in the mammalian UVC response. Cell 78: 963-972, 1994.
18. Miller CC, Hale P and Pentland AP: Ultraviolet B injury increases prostaslandin synthesis through a tyrosine kinase-dependent pathway. J Biol Chem 269: 3529-3533, 1994.
19. Rosette C and Karin M: Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274: 1194-1197, 1996.
20. Adler V, Polotskaya A, Kim J, Dolan L, Davis R, Pincus M and Ronai Z: Dose rate and mode of exposure are key factors in JNK activation by UV irradiation. Carcinogenesis 17: 2073-2076, 1996.
21. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ and Davis RJ: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270: 7420-7426, 1995.
22. Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D and Kharbanda S: Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and independent mechanisms. J Biol Chem 271: 23775-23779, 1996.
23. Alexandrow MG and Moses HL: Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res 55: 3928-3932, 1995.
24. Wrana JL, Attisano L, Wieser R, Ventura F and Massagué J: Mechanism of activation of the TGF-β receptor. Nature 370: 341-347, 1994.
25. Massagué J: TGFβ signaling: receptors, transducers, and Mad proteins. Cell 85: 947-950, 1996.
26. Atfi A, Djelloul S, Chastre E, Davis R and Gespach C: Evidence for a role of Rho-like GTPascs and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated sicnaling. J Biol Chem 272: 1429-1432, 1997.
27. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A and Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106: 761-771, 1988.
28. Lehman TA, Modali R, Boukamp P, Stanek J, Bennett WP, Welsh JA, Metcalf RA, Stampfer MR, Fusenig N, Rogan EM and Harris CC: p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14: 833-839, 1993.
29. Rizzino A, Kazakoff P, Ruff E, Kuszynski C and Nebelsick J: Regulatory effects of cell density on the binding of transforming growth factor β, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. Cancer Res 48: 4266-4271, 1988.
30. Frangioni JV and Neel BG: Solubilization and purification of enzymatically active glutathtone S-transferase (pGEX) fusion proteins. Anal Biochem 210: 179-187, 1993.
31. Westwick JK and Brenner DA: Methods for analyzing c-jun kinase. Methods Enzymol 255: 342-359, 1995.
32. Van Z, Winawer S and Friedman E: Two different signal transductton pathways can be activated by transforming growth factor β1 in epithelial cells. J Biol Chem 269: 13231-13237, 1994.
33. Angel P, Hattori K, Smeal T and Karin M: The jun protooncogene is positively autoregulated by its product, Jun/AP-1. Cell 55: 875-885, 1988.
34. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E and Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-β sienal transduction. Science 270: 2008-2011, 1995.
35. Gaido KW, Maness SC, Leonard LS and Greenlee WF: 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J Biol Chem 267: 24591-24595, 1992.
36. Fowlis DJ, Flanders KC, Duffie E, Balmain A and Akhurst RJ: Discordant transforming growth factor β1 RNA and protein localization during chemical carcinogenesis of the skin. Cell Growth Dev 3: 81-91, 1992.
37. Akhurst RJ, Fee F and Balmain A: Localized production of TGF-β mRNA in tumor promoter-stimulated mouse epidermis. Nature 331: 363-365, 1988.
38. Sherman JH, Baxter CS and Albert RE: Stimulation of TGF-β1 mRNA concentration in mouse skin treated with benzo[a]pyrene. Carcinogenesis 13: 83-86, 1992.
39. Slaga TJ, Budunova IV, Gimenez-Conti IB and Aldaz CM: The mouse skin carcinogenesis model. J Invest Dermatol Symp Proc 1: 151-156, 1996.
40. Wang W, Zhou G, Hu MC-T, Yao Z and Tan T-H: Activation of the hematopoietic progenitor kinase-I (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor β(TGF-β)-activated kinase (TAK1), a kinase mediator of TGF-β signal transduction. J Biol Chem 272: 22771-22775, 1997.
41. Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E and Hagiwara M: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem 271: 13675-13679, 1996.
42. 2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. J Biol Chem 272: 14489-14496, 1997.
43. Lu ML, Sato M, Cao B and Richie JP: UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells. Proc Natl Acad Sci USA 93: 8977-8982, 1996.
44. Zanke BW, Rubie EA, Winnett E, Chan J, Randall S, Parsons M, Boudreau K, McInnis M, Yan M, Templeton DJ and Woodgett JR: Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes. J Biol Chem 271: 29876-29881, 1996.
45. Moriguchi T, Kawasaki H, Matsuda S, Gotoh Y and Nishida E: Evidence of multiple activators for stress-activated protein kinases/c-Jun amino-terminal kinases. J Biol Chem 270: 12969-12972, 1995.
46. Yan M, Dal T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR and Templeton DJ: Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372: 798-800, 1994.
47. Blank JL, Gerwins P, Elliott EM, Sather S and Johnson GL: Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. J Biol Chem 271: 5361-5368, 1996.
48. Ellinger-Zicgelbauer H, Brown K, Kelly K and Siebenlist U: Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem 272: 2668-2674, 1997.
49. Gerwins P, Blank JL and Johnson GL: Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem 272: 8288-8295, 1997.
50. Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan T-H, Lichenstein H, Zukowski M and Yao Z: Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J Biol Chem 271: 31607-31611, 1996.
51. Moriguchi T, Toyoshima F, Masuyama N, Hanafusa H, Gotoh Y and Nishida E: A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses. EMBO J 16: 7045-7053, 1997.
52. 2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci USA 94: 3004-3009, 1997.
53. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways. Science 275: 90-94, 1997.
54. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T and Brash DE: Sunburn and p53 in the onset of skin cancer. Nature 372: 773-776, 1994.
55. Ellem KAO, Cullinan M, Baumann KC and Dunstan A: UVR induction of TGF-α: a possible autocrine mechanism for the epidermal melanocytic response and for promotion of epidermal carcinogenesis. Carcinogenesis 9: 797-801, 1988.
56. Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M and Dent P: The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol Biol Cell 9: 561-573, 1998.