Discoidin domain receptor 2 impairs insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation and glucose uptake in 3T3-L1 adipocytes

Hormone and Metabolic Research

Volumn 39, Issue 8, 2007, Pages 575-581

  Zurakowski, H ^a   Gagnon, A ^a   Landry, A ^a   Layne, M D ^b   Sorisky, A ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Collagen; Differentiation; Extracellular matrix; Insulin resistance; Preadipocyte; Proliferation

Indexed keywords

CCAAT BINDING FACTOR; DISCOIDIN; FATTY ACID SYNTHASE; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN DDR2; TRIACYLGLYCEROL; TYROSINE; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; MITOSIS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; GLUCOSE; INSULIN; INSULIN RESISTANCE; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN; TRANSFECTION;

EID: 34548340719     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-985132     Document Type: Article

References (36)

1. Rajala MW, Scherer PE. The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144: 3765-3773
2. Danforth Jr E. Failure of adipocyte differentiation causes type 2 diabetes mellitus? Nature Gen 2000; 26: 13
3. Heilbronn L, Smith SR, Ravussin E. Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type 2 diabetes mellitus. Int J Obesity 2004; 28: S12-S21
4. Janke J, Engeli S, Gorzelniak K et al. Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity. Horm Metab Res 2006; 38: 28-33
5. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783-809
6. Bouloumie A, Sengenes C, Portolan G, Galitzky J, Lafontan M. Adipocyte produces matrix metalloproteinases 2 and 9. Diabetes 2001; 50: 2080-2086
7. Rodriguez Fernandez JL, Ben-Ze'ev A. Regulation of fibronectin, integrin and cytoskeleton expression in differentiating adipocytes: inhibition by extracellular matrix and polylysine. Differentiation 1989; 42: 65-74
8. Liu J, Young S De, Zhang M et al. Changes in integrin expression during adipocyte differentiation. Cell Metab 2005; 2: 165-177
9. Vogel W, Gish CD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1997; 1: 13-23
10. Shrivastava A, Radziejewski C, Campbell E et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell 1997; 1: 25-34
11. Vogel WF, Abdulhussein R, Ford CE. Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signaling 2006; 18: 1108-1116
12. Ikeda K, Wang L-H, Torres R et al. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem 2002; 277: 19206-19212
13. Yang K, Kim JH, Kim HJ et al. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. J Biol Chem 2005; 280: 39058-39066
14. Olaso E, Labrador J-P, Wang L et al. Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem 2002; 277: 3606-3613
15. Ferri N, Carragher NO, Raines EW. Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling. Am J Pathol 2004; 164: 1575-1585
16. Xu L, Peng H, Wu D et al. Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem 2005; 280: 548-555
17. Labrador JP, Azcoitia V, Tuckermann J et al. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2001; 2: 446-452
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 177: 156-159
19. Gagnon A, Landry A, Proulx J, Layne MD, Sorisky A. Aortic carboxypeptidase-like protein is regulated by transforming growth factor β in 3T3-Ll preadipocytes. Exp Cell Res 2005; 308: 265-272
20. El-Chaar D, Gagnon A, Sorisky A. Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase versus eIF4E-BP1. Int J Obesity 2004; 28: 191-198
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685
22. Gagnon A, Artemenko Y, Crapper T, Sorisky A. Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. J Cell Physiol 2003; 197: 243-250
23. Gagnon A, Chen C-S, Sorisky A. Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes. Contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate. Diabetes 1999; 48: 691-698
24. Cianflone K, Roncari DAK, Maslowska M et al. Adipsin/acylation stimulation protein system in human adipocytes: regulation of triacylglycerol synthesis. Biochemistry 1994; 33: 9489-9495
25. Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 2005; 146: 1328-1337
26. Sun XJ, Pons S, Wang L-M et al. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol Endocrinol 1997; 11: 251-262
27. El-Jack AK, Hamm JK, Pilch PF, Farmer SR. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARγ and C/EBPα. J Biol Chem 1999; 274: 7946-7951
28. Wertheim N, Cai Z, MacGraw TE. The transcription factor CCAAT/Enhancer-binding protein α is required for the intracellular retention of GLUT4. J Biol Chem 2004; 279: 41468-41476
29. Wall SJ, Werner ED, Werb Z, Clerck YA De. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem 2005; 280: 40187-40194
30. Tang Q-Q, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA 2003; 100: 44-49
31. Le Lay S, Krief S, Farmer C et al. Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem 2001; 276: 16904-16910
32. Shoelson SE, Lee J, Yuan M. Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance. Int J Obesity 2003; 27: S49-S52
33. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112: 1785-1788
34. Lehrke M, Lazar MA. Inflamed about obesity. Nat Medicine 2004; 10: 126-127
35. Venable CL, Frevert EU, Kim Y-B et al. Overexpression of Protein-tyrosine Phosphatase-1B in Adipocytes Inhibits Insulin-stimulated Phosphoinositide 3-Kinase Activity without Altering Glucose Transport or Akt/Protein Kinase B Activation. J Biol Chem 2000; 275: 18318-18326
36. Hiraiwa H, Sawazaki T, Suzuki K et al. Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes. Cytogenet Genome Res 2003; 101: 84-89