An in vitro model of T cell receptor revision in mature human CD8+ T cells

Molecular Immunology

Volumn 45, Issue 2, 2008, Pages 328-337

  Lantelme, Erica ^a   Orlando, Luca ^a   Porcedda, Paola ^a   Turinetto, Valentina ^a   De Marchi, Mario ^a   Amoroso, Antonio ^a   Mantovani, Stefania ^b   Giachino, Claudia ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b IRCCS   (Italy)

Author keywords

Human; IL7; RAG 1; RAG 2; T cells; TCR revision; TCR CD3 down regulation

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 7; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL SURFACE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

ANTIBODIES; ANTIGENS, CD3; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CLONE CELLS; DNA-BINDING PROTEINS; DOWN-REGULATION; ENTEROTOXINS; FLUORESCENT ANTIBODY TECHNIQUE; GENE REARRANGEMENT, T-LYMPHOCYTE; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-7; MODELS, IMMUNOLOGICAL; NUCLEAR PROTEINS; PROTEIN ISOFORMS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

MURINAE;

EID: 34548290872     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.06.153     Document Type: Article

References (49)

1. Akiyama M., Kyoizumi S., Hirai Y., Kusunoki Y., Iwamoto K.S., and Nakamura N. Mutation frequency in human blood cells increases with age. Mutat. Res. 338 (1995) 141-149
2. Al-Rawi M.A., Rmali K., Watkins G., Mansel R.E., and Jiang W.G. Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer. Eur. J. Cancer 40 (2004) 494-502
3. Bas A., Hammarstrom S.G., and Hammarstrom M.L. Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression. J. Immunol. 171 (2003) 3359-3371
4. Bynoe M.S., Viret C., Flavell R.A., and Janeway Jr. C.A. T cells from epicutaneously immunized mice are prone to T cell receptor revision. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 2898-2903
5. Cooper C.J., Orr M.T., McMahan C.J., and Fink P.J. T cell receptor revision does not solely target recent thymic emigrants. J. Immunol. 171 (2003) 226-233
6. Cooper C.J., Turk G.L., Sun M., Farr A.G., and Fink P.J. Cutting edge: TCR revision occurs in germinal centers. J. Immunol. 173 (2004) 6532-6536
7. Coppola M.A., and Blackman M.A. Bacterial superantigens reactivate antigen-specific CD8+ memory T cells. Int. Immunol. 9 (1997) 1393-1403
8. Deringer J.R., Ely R.J., Stauffacher C.V., and Bohach G.A. Subtype-specific interactions of type C staphylococcal enterotoxins with the T cell receptor. Mol. Microbiol. 22 (1996) 523-534
9. Fink P.J., and McMahan C.J. Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe. Immunol. Today 21 (2000) 561-566
10. Fry T.J., and Mackall C.L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174 (2005) 6571-6576
11. Fugmann S.D., Lee A.I., Shockett P.E., Villey I.J., and Schatz D.G. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18 (2000) 495-527
12. Gellert M. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71 (2002) 101-132
13. Giachino C., Padovan E., and Lanzavecchia A. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. Eur. J. Immunol. 28 (1998) 3506-3513
14. Hofmeister R., Khaled A.R., Benbernou N., Rajnavolgyi E., Muegge K., and Durum S.K. Interleukin-7: physiological roles and mechanisms of action. Cytokine Growth Factor Rev. 10 (1999) 41-60
15. Huang C.Y., Golub R., Wu G.E., and Kanagawa O. Superantigen-induced TCR alpha locus secondary rearrangement: role in tolerance induction. J. Immunol. 168 (2002) 3259-3265
16. Huang J., and Muegge K. Control of chromatin accessibility for V(D)J recombination by interleukin-7. J. Leukoc. Biol. 69 (2001) 907-911
17. Huster K.M., Busch V., Schiemann M., Linkemann K., Kerksiek K.M., Wagner H., and Busch D.H. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 5610-5615
18. Kaech S.M., Tan J.T., Wherry E.J., Konieczny B.T., Surh C.D., and Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4 (2003) 1191-1198
19. Kim K.S., Jacob N., and Stohl W. In vitro and in vivo T cell oligoclonality following chronic stimulation with staphylococcal superantigens. Clin. Immunol. 108 (2003) 182-189
20. Kondo E., Wakao H., Koseki H., Takemori T., Kojo S., Harada M., Takahashi M., Sakata S., Shimizu C., Ito T., Nakayama T., and Taniguchi M. Expression of recombination-activating gene in mature peripheral T cells in Peyer's patch. Int. Immunol. 15 (2003) 393-402
21. Kuklina E.M. Revision of the antigen receptor of T-lymphocytes. Biochemistry (Moscow) 71 (2006) 827-837
22. Kyoizumi S., Akiyama M., Hirai Y., Kusunoki Y., Tanabe K., and Umeki S. Spontaneous loss and alteration of antigen receptor expression in mature CD4+ T cells. J. Exp. Med. 171 (1990) 1981-1999
23. Lantelme E., Palermo B., Granziero L., Mantovani S., Campanelli R., Monafo V., Lanzavecchia A., and Giachino C. Cutting edge: recombinase-activating gene expression and V(D)J recombination in CD4+CD3low mature T lymphocytes. J. Immunol. 164 (2000) 3455-3459
24. Lantelme E., Mantovani S., Palermo B., Campanelli R., Granziero L., Monafo V., and Giachino C. Increased frequency of RAG-expressing CD4(+)CD3(low) peripheral T lymphocytes in patients with defective responses to DNA damage. Eur. J. Immunol. 30 (2000) 1520-1525
25. Lantelme E., Turinetto V., Mantovani S., Marchi A., Regazzoni S., Porcedda P., De Marchi M., and Giachino C. Analysis of secondary V(D)J rearrangements in mature, peripheral T cells of ataxia-telangiectasia heterozygotes. Lab. Invest. 83 (2003) 1467-1475
26. MacLennan I.C. Germinal centers. Annu. Rev. Immunol. 12 (1994) 117-139
27. Mantovani S., Palermo B., Garbelli S., Campanelli R., Robustelli Della Cuna G., Gennari R., Benvenuto F., Lantelme E., and Giachino C. Dominant TCR-alpha requirements for a self antigen recognition in humans. J. Immunol. 169 (2002) 6253-6260
28. Mayerova D., and Hogquist K.A. Central tolerance to self-antigen expressed by cortical epithelial cells. J. Immunol. 172 (2004) 851-856
29. McGargill M.A., Derbinski J.M., and Hogquist K.A. Receptor editing in developing T cells. Nat. Immunol. 1 (2000) 336-341
30. McMahan C.J., and Fink P.J. RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity 9 (1998) 637-647
31. McMahan C.J., and Fink P.J. Receptor revision in peripheral T cells creates a diverse V beta repertoire. J. Immunol. 165 (2000) 6902-6907
32. Meijer H.A., and Thomas A.A. Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an Mrna. Biochem. J. 367 (2002) 1-11
33. Mostoslavsky R., and Alt F.W. Receptor revision in T cells: an open question?. Trends Immunol. 25 (2004) 276-279
34. Muegge K., Vila M.P., and Durum S.K. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Science 261 (1993) 93-95
35. Nemazee D. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6 (2006) 728-740
36. Oettinger M.A. How to keep V(D)J recombination under control. Immunol. Rev. 200 (2004) 165-181
37. Oettinger M.A., Schatz D.G., Gorka C., and Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248 (1990) 1517-1523
38. Puellmann K., Kaminski W.E., Vogel M., Nebe C.T., Schroeder J., Wolf H., and Beham A.W. A variable immunoreceptor in a subpopulation of human neutrophils. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 14441-14446
39. Sauce D., Larsen M., Leese A.M., Millar D., Khan N., Hislop A.D., and Rickinson A.B. IL-7R alpha versus CCR7 and CD45 as markers of virus-specific CD8+ T cell differentiation: contrasting pictures in blood and tonsillar lymphoid tissue. J. Infect. Dis. 195 (2007) 268-278
40. Schlissel M., Constantinescu A., Morrow T., Baxter M., and Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7 (1993) 2520-2532
41. Serra P., Amrani A., Han B., Yamanouchi J., Thiessen S.J., and Santamaria P. RAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15566-15571
42. Spicuglia S., Franchini D.M., and Ferrier P. Regulation of V(D)J recombination. Curr. Opin. Immunol. 18 (2006) 158-163
43. Turka L.A., Schatz D.G., Oettinger M.A., Chun J.J., Gorka C., Lee K., McCormack W.T., and Thompson C.B. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 253 (1991) 778-781
44. Vaitaitis G.M., Poulin M., Sanderson R.J., Haskins K., and Wagner Jr. D.H. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. J. Immunol. 170 (2003) 3455-3459
45. Valitutti S., Muller S., Cella M., Padovan E., and Lanzavecchia A. Serial triggering of many T cell receptors by a few peptide-MHC complexes. Nature 375 (1995) 148-151
46. van Leeuwen E.M., de Bree G.J., Remmerswaal E.B., Yong S.L., Tesselaar K., ten Berge I.J., and van Lier R.A. IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood 106 (2005) 2091-2098
47. Wang F., Huang C.Y., and Kanagawa O. Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11834-11839
48. Wilson A., Held W., and MacDonald H.R. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179 (1994) 1355-1360
49. Yannoutsos N., Barreto V., Misulovin Z., Gazumyan A., Yu W., Rajewsky N., Peixoto B.R., Eisenreich T., and Nussenzweig M.C. A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat. Immunol. 5 (2004) 443-450