Bacterial superantigens reactivate antigen-specific CD8+ memory T cells

International Immunology

Volumn 9, Issue 9, 1997, Pages 1393-1403

  Coppola, Michael A ^a   Blackman, Marcia A ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Cellular activation; Cytotoxic T lymphocyte; Infectious immunity virus; Memory superantigens

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; LYMPHOKINE; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; CELL SECRETION; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; INFLUENZA VIRUS; LYMPHOCYTE CULTURE; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

ANIMALS; ANTIGENS, BACTERIAL; CYTOTOXICITY, IMMUNOLOGIC; ENTEROTOXINS; EPITOPES, T-LYMPHOCYTE; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED CBA; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0030763943     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.9.1393     Document Type: Article

References (85)

1. Herman, A., Kappler, J. W., Marrack, P. and Pullen, A. M. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745.
2. Marrack, P. and Kappler, J. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705.
3. Choi, Y. W., Kotzin, B., Herren, L., Callahan, J., Marrack, P. and Kappler, J. 1989. Interaction of Staphylococcus aureus toxin 'superantigens' with human T cells. Proc. Natl Acad. Sci. USA 86:8941.
4. β-specific Stimulation of human T cells by staphylococcal toxins. Science 244:811.
5. Dellabona, P., Peccoud, J., Kappler, J., Marrack, P., Benoist, C. and Mathis, D. 1990. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 62:1115.
6. Fleischer, B. and Schrezenmeier, H. 1988. T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J. Exp. Med. 167:1697.
7. Mollick, J. A., Chintagumpala, M., Cook, R. G. and Rich, R. R. 1991. Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype. J. Immunol. 146:463.
8. + cells to bacterial superantigens. Eur. J. Immunol. 22:1935.
9. β usage of the responder T cells. J. Immunol. 144:1181.
10. Herrmann, T. and MacDonald, H. R. 1993. The CDS T cell response to Staphylococcal enterotoxins. Semin. Immunol. 5:33.
11. Bette, M., Schafer, M. K., van Rooijen, N., Weihe, E. and Fleischer, B. 1993. Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. J. Exp. Med. 178:1531.
12. Litton, M. J., Sander, B., Murphy, E., O'Garra, A. and Abrams, J.S. 1994. Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B. J. Immunol. Methods 175:47.
13. β-specific superantigen Staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27.
14. + T cells in mice tolerant to Staphylococcus aureus enterotoxin. Nature 349:245.
15. McCormack, J. E., Callahan, J. E., Kappler, J. and Marrack, P. C. 1993. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785.
16. + T cells by Staphylococcal enterotoxin B. J. Exp. Med. 172:1091.
17. + T cells. J. Immunol. 154:6306.
18. + peripheral T cells responding to Staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 21:1963.
19. Baschieri, S., Lees, R. K., Lussow, A. R. and MacDonald, H. R. 1993, Clonal anergy to Staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. Eur. J. Immunol. 23:2661.
20. Scott, D. E., Kisch, W. J. and Steinberg, A. D. 1993. Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice. J. Immunol. 150:664.
21. Dannecker, G., Schultz, H., Mecheri, S., Sappier, G., Clarke, K., Niethammer, D. and Hoffmann, M. K. 1993. Characterization of anergy to the superantigen Staphylococcus enterotoxin B. Immunodeficiency 4:137.
22. Mahlknecht, U., Herter, M., Hoffmann, M. K., Niethammer, D. and Dannecker, G. E. 1996. The toxic shock syndrome toxin-1 induces anergy in human T cells in vivo. Human Immunol. 45:42.
23. Heeg, K. and Wagner, H. 1995. Induction of responsiveness in superantigen-induced anergic T cells. Role of ligand density and costimulatory signals. J. Immunol. 155:83.
24. Heeg, K., Gaus, H., Griese, D., Bendigs, S., Miethke, T. and Wagner, H. 1995. Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo. Int. Immunol. 7:105.
25. Schultz, H., Geiselhart, A., Sappler, G., Niethammer, D., Hoffmann, M. K. and Dannecker, G. E. 1996. The superantigen Staphylococcus enterotoxin B induces a strong and accelerated secondary T-cell response rather than anergy. Immunology 87:49.
26. + T cells. J. Immunol. 150:3873.
27. Sundstedt, A., Dohlsten, M., Hedlund, G., Höidén, l., Björklund, M. and Kalland, T. 1994. Superantigens anergize cytokine production but not cytotoxicity in vivo. Immunology 82:117.
28. Byrne, J. A., Butler, J. L. and Cooper, M. D. 1988. Differential activation requirements for virgin and memory T cells. J. Immunol. 141:3249.
29. + and can be selectively activated with phorbol ester and calcium ionophore. Cell. Immunol. 113:268.
30. - memory T lymphocytes. J. Immunol. 143:1761
31. Dianzani, U., Luqman, M., Rojo, J., Yagi, J., Baron, J. L., Woods, A., Janeway, C. A., Jr and Bottomly, K. 1990. Molecular associations on the T cell surface correlate with immunological memory. Eur J. Immunol. 20:2249.
32. + T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway. J. Immunol. 148:1993.
33. + T cells are hyperreactive to antigenic challenge in vitro J. Exp. Med. 184:2141.
34. Hamel, M. E., Eynon, E. E., Savelkoul, H. F., van Oudenaren, A. and Kruisbeek, A. M. 1995. Activation and re-activation potential of T cells responding to staphylococcal enterotoxin B. Int. Immunol. 7:1065.
35. Lee, W. T. and Vitetta, E. S. 1992. Memory T cells are anergic to the superantigen staphylococcal enterotoxin B. J. Exp. Med. 176:575.
36. Lussow, A. R. and MacDonald, H. R. 1994. Differential effects of superantigen-induced 'anergy' on priming and effector stages of a T cell-dependent antibody response. Eur. J. Immunol. 24:445.
37. + TcR-associated T-cell memory against conventional antigen. Cell Immunol. 160:58.
38. + T-cell memory to viruses. Curr. Opin. Immunol. 6:545.
39. Doherty, P. C. 1996. Cytotoxic T cell effector and memory function in viral immunity. Curr. Top. Microbiol. Immunol. 206:1.
40. + T cell memory. Immunol. Rev. 150:23.
41. + T cells in respiratory virus infections. J. Immunol. 154:6013.
42. Liang, S., Mozdzanowska, K., Palladino, G. and Gerhard, W. 1994. Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity. J. Immunol. 152:1653.
43. Blackman, M. A., Gerhard-Burgert, H., Woodland, D. L., Palmer, E., Kappler, J. W. and Marrack, P. 1990. A role for clonal inactivation in T cell tolerance to MIs-1a. Nature 345:540.
44. Kilbourne, E. D. 1969. Future influenza vaccines and the use of genetic recombinants. Bull. WHO 41:643.
45. b-restricted response to an influenza A virus nucleoprotein epitope. J Immunol. 151:2658
46. Zhang, W. J., Sarawar, S., Nguyen, P., Daly, K., Rehg, J. E., Doherty, P. C., Woodland, D. L. and Blackman, M. A. 1996. Lethal synergism between influenza infection and staphylococcal enterotoxin B in mice. J. Immunol. 157:5049.
47. Oi, V. T. Jones, P. P., Goding, J. W. and Herzenberg, L. A. 1978. Properties of monoclonal antibodies to mouse lg allotypes, H-2, and la antigens. Curr. Top. Microbiol. Immunol. 81:115.
48. Ozato, K., Mayer, N. and Sachs, D. H. 1980. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens. J. Immunol. 124:533.
49. Dialynas, D. P., Quan, Z. S., Wall, K. A., Pierres, A., Quintans, J., Loken, M. R., Pierres, M. and Fitch, F. W. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445.
50. + T cells. Virology 210:179.
51. Sarmiento, M., Glasebrook, A. L. and Fitch, F. W. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cellmediated cytolysis in the absence of complement. J. Immunol. 125:2665.
52. Lesley, J. and Trowbridge, I. S. 1982. Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics 15:313.
53. Ledbetter, J. A. and Herzenberg, L. A. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63.
54. Gallatin, W. M., Weissman, I. L. and Butcher, E. C. 1983. A cellsurface molecule involved in organ-specific homing of lymphocytes. Nature 304:30.
55. Ronchese, F., Brown, M. A. and Germain, R. N. 1987. Structure-function analysis of the Abm12b mutation using site-directed mutagenesis and DNA-mediated gene transfer. J. Immunol. 139:629.
56. b. J. Immunol. 129:689.
57. + T cells. J. Immunol. 144:3980.
58. + T cells. J. Immunol. 149:1319.
59. + T cells in lymph node and lung of mice with Sendai virus pneumonia by LECAM-1 and CD45RB phenotype. J. Immunol. 150:5494.
60. Taswell, C. 1981. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126:1614.
61. + T-cell responses in mice transgenic for a T-cell receptor β chain selected at random. J. Virol. 68:3065.
62. Daly, K., Nguyen, P., Woodland, D. L. and Blackman, M. A. 1995. Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire. J. Virol. 69:7416.
63. Bennink, J. R. and Yewdell, J. W. 1988. Murine cytotoxic T lymphocyte recognition of individual influenza virus proteins. High frequency of nonresponder MHC class I alleles. J. Exp. Med. 168:1935.
64. k-restricted T-cell epitopes within the influenza A/PR/8/34 virus hemagglutinin. J. Virol. 65:5401.
65. k-restricted cytotoxic T cell epitope in the NS1 protein of influenza virus using an MHC allelespecific motif. Virology 193:289.
66. Yewdell, J. W., Bennink, J. R., Smith, G. L. and Moss, B. 1985. Influenza A virus nucleoprotein is a major target antigen for crossreactive anti-influenza A virus cytotoxic T lymphocytes. Proc. Natl Acad. Sci. USA 82:1785.
67. Dohlsten, M., Lando, P. A., Hedlund, G., Trowsdale, J. and Kalland, T. 1990. Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins. Immunology 71:96.
68. + memory T cells. J. Immunol. 154:5870.
69. Matsui, K., Boniface, J. J., Reay, P. A., Schild, H., Fazekas de St Groth, B. and Davis, M. M. 1991. Low affinity interaction of peptide-MHC complexes with T cell receptors. Science 254:1788.
70. Weber, S., Traunecker, A., Oliveri, F., Gerhard, W. and Karjalainen, K. 1992. Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356:793.
71. Malchiodi, E. L., Eisenstein, E., Fields, B. A., Ohlendorf, D. H., Schlievert, P. M., Karjalainen, K. and Mariuzza, R. A. 1995. Superantigen binding to a T cell receptor beta chain of known three-dimensional structure. J. Exp. Med. 182:1833.
72. Woodland, D. L., Wen, R. and Blackman, M. A. 1997. Why do superantigens care about peptides? Immunol. Today 18:18.
73. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
74. + T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251:1228.
75. Beverly, B., Kang, S. M., Lenardo, M. J. and Schwartz, R. H. 1992. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4:661.
76. Chen, C. and Nabavi, N. 1994, In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity 1:147.
77. Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
78. Lee, W. T., Thrush, G. R. and Vitetta, E. S. 1995. Staphylococcal enterotoxin B induces the expression of activation markers on murine memory T cells in the absence of proliferation or lymphokine secretion. Cell. Immunol. 162:26.
79. + lymphocyte subsets. Microb. Pathol. 14:75.
80. Doherty, P. C., Effros, R. B. and Bennink, J. 1977. Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses. Proc. Natl Acad. Sci. USA 74:1209.
81. Jenkins, M. K. and Schwartz, R. H. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
82. Lamb, J. R., Skidmore, B. J., Green, N., Chiller, J. M. and Feldmann, M. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
83. Zanders, E. D., Feldmann, M. and Lamb, J. R. 1985. Biochemical events initiated by exposure of human T lymphocyte clones to immunogenic and tolerogenic concentrations of antigen. Eur. J. Immunol. 15:302.
84. Akbar, A. N., Salmon, M. and Janossy, G. 1991 The synergy between naive and memory T cells during activation, Immunol. Today 12:184.
85. Murphy, B. R. and Webster, R. G. 1996. Orthomyxoviruses. In Fields, B. N., Knipe, D. M. and Howley. P. M., eds, Fields Virology, p. 1397. Lipincott-Raven, Philadelphia.