Human β defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases

Journal of Periodontal Research

Volumn 42, Issue 5, 2007, Pages 429-437

  Vardar Sengul, S ^a,b   Demirci, T ^c   Sen, B H ^a   Erkizan, V ^c   Kurulgan, E ^d   Baylas, H ^a  

^a EGE UNIVERSITY   (Turkey)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DOKUZ EYLUL UNIVERSITY   (Turkey)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Defensin; Gingiva; Gingivitis; Periodontitis; Real time polymerase chain reaction

Indexed keywords

ANTIINFECTIVE AGENT; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN; DEFB4 PROTEIN, HUMAN; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHRONIC DISEASE; CLASSIFICATION; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GINGIVA; GINGIVITIS; HUMAN; MALE; METABOLISM; MIDDLE AGED; PERIODONTITIS;

ADULT; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CHRONIC DISEASE; FEMALE; GENE EXPRESSION REGULATION; GINGIVA; GINGIVITIS; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 34548210843     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2006.00964.x     Document Type: Article

References (30)

1. Abiko Y, Mitamura J, Nishimura M et al. Pattern of expression of beta defensin in oral squamous cell carcinoma. Cancer Lett 1999 143 : 37 43.
2. Wilson CL, Oulette AJ, Satchell DP et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999 286 : 113 117.
3. Weinberg A, Krisanaprakornkit S, Dale BA. Epithelial antimicrobial peptides: Review and significance for oral applications. Crit Rev Oral Biol Med 1998 9 : 399 414.
4. McCray PB, Bentley L. Human airway epithelia express a β defensin. Am J Resp Cell Mol Biol 1997 16 : 343 349.
5. Diamond DL, Kimball JR, Krisanaprakornkit S, Ganz T, Dale BA. Detection of β defensins secreted by human oral epithelial cells. J Immunol Methods 2001 256 : 65 76.
6. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sides of inflammation. Science 1995 267 : 1645 1648.
7. Mathews M, Jia HP, Guthmiller JM et al. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999 67 : 2740 2745.
8. Lu Q, Jin L, Darveau RP, Samaranayake LP. Expression of human beta-defensins-1 and -2 peptides in unresolved chronic periodontitis. J Periodont Res 2004 39 : 221 227.
9. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000 68 : 2907 2915.
10. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA. Expression of the peptide antibiotic human β defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998 66 : 4222 4228.
11. Dale BA, Kimball JR, Krisanaprakornkit S et al. Localized antimicrobial peptide expression in human gingiva. J Periodont Res 2001 36 : 285 294.
12. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999 4 : 1 7.
13. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964 22 : 121 135.
14. Saxer UP, Mühlemann HR. Motivation and instruction. Schweiz Monatschr Zahnheilk 1975 85 : 905 919.
15. Demirci T, Trzewik J, Linder P, Digel I, Artmann GM, Temiz Artmann A. Mechanical stimulation of 3t3 fibroblasts activates genes: itgb5 and p53 responses as quantified on the mRNA level. Biomed Tech (Berl) 2004 2 : 1030 1031.
16. Demirci T, Trzewik J, Linder P, Artmann GM, Temiz Artmann A. Mechanical stimulation of 3t3 fibroblasts activates genes: Real Time PCR products and suppliers by comparison. Biomed Tech (Berl) 2004 2 : 1046 1047.
17. Dunsche A, Açil Y, Siebert R, Harder J, Schröder JM, Jepsen S. Expression profile of human defensins and antimicrobial proteins in oral tissues. J Oral Pathol Med 2001 30 : 154 158.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001 29 : e45.
19. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002 30 : e36.
20. Bals R, Wang X, Wu Z, et al. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998 102 : 874 880.
21. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997 88 : 553 560.
22. Chung WO, Dale BA. Innate immune response of oral and foreskin keratinocytes: Utilization of different signaling pathways by various bacterial species. Infect Immun 2004 72 : 352 358.
23. Van der Weijden GA, Timmerman MF, Danser MM, Nijboer A, Saxton CA, Van der Velden U. Effect of pre-experimental maintenance care duration on the development of gingivitis in a partial mouth experimental gingivitis model. J Periodont Res 1994 29 : 168 173.
24. Liu L, Wang L, Jia HP et al. Structure and mapping of the human beta defensin HBD-2 gene and its expression at sites of inflammation. Gene 1998 222 : 237 244.
25. O'Neil DA, Porter EM, Elewaut E et al. Expression and regulation of human beta defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999 163 : 6718 6724.
26. Haffajee AD, Cugini MA, Tanner A, Pollack RP, Smith C, Kent JRL. Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects. J Clin Periodontol 1998 25 : 346 353.
27. Liu L, Roberts A, Ganz T. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol 2003 170 : 575 580.
28. Dommish H, Acil Y, Dunsche A, Winter J, Jepsen S. Differential gene expression of human β-defensins (hBD-1-2-3) in inflammatory gingival diseases. Oral Microbiol Immunol 2005 20 : 186 190.
29. Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human β-defensin-2 in gingival epithelial cells. The involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family. J Immunol 2002 168 : 316 324.
30. Chung WO, Hansen SR, Rao D, Dale BA. Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J Immunol 2004 173 : 5165 5170.