Expression of human β-defensins-1 and -2 peptides in unresolved chronic periodontitis

Journal of Periodontal Research

Volumn 39, Issue 4, 2004, Pages 221-227

  Lu, Qian ^a   Jin, Lijian ^a,c   Darveau, Richard P ^b   Samaranayake, Lakshman P ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chronic periodontitis; Gingival epithelium; Human defensins; Immunohistochemistry

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2;

ADULT; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GINGIVA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PERIODONTITIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CHRONIC DISEASE; CYTOPLASM; EPITHELIUM; EXTRACELLULAR SPACE; GINGIVA; GRANULATION TISSUE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; PERIODONTAL POCKET; PERIODONTITIS; PERIODONTIUM; UP-REGULATION;

EID: 3242751259     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2004.00727.x     Document Type: Article

References (35)

1. Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997;14:12-32.
2. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:216-248.
3. Yang D, Biragyn A, Kwak LW, Oppenheim JJ. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol 2002;23:291-296.
4. Dale BA, Kimball JR, Krisanaprakornkit S et al. Localized antimicrobial peptide expression in human gingiva. J Periodont Res 2001;36:285-294.
5. Harder J, Bartels J, Christophers E, Schröder JM. A peptide antibiotic from human skin. Nature 1997;387:861.
6. Ganz T, Lehrer RI. Defensins. Pharmacol Ther 1995;66:191-205.
7. Ganz T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun 1987;55:568-571.
8. Quayle AJ, Porter EM, Nussbaum AA et al. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998;152:1247-1258.
9. Jones DE, Bevins CL. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett 1993;315:187-192.
10. Porter EM, Liu L, Oren A, Anton PA, Ganz T. Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun 1997;65:2389-2395.
11. Harder J, Bartels J, Christophers E, Schröder JM. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001;276:5707-5713.
12. Dunsche A, Acil Y, Dommisch H, Siebert R, Schröder JM, Jepsen S. The novel human beta-defensin-3 is widely expressed in oral tissues. Eur J Oral Sci 2002;110:121-124.
13. Garcia JR, Krause A, Schulz S et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001;15:1819-1821.
14. Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG. hBD-1: a novel beta-defensin from human plasma. FEBS Lett 1995;368:331-335.
15. Zhao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996;396:319-322.
16. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB Jr, Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998;101:1633-1642.
17. Mathews M, Jia HP, Guthmiller JM et al. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999;67:2740-2745.
18. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA. Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998;66:4222-4228.
19. Chronnell CM, Ghali LR, Ali RS et al. Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. J Invest Dermatol 2001;117:1120-1125.
20. Bajaj-Elliott M, Fedeli P, Smith GV et al. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 2002;51:356-361.
21. Lehmann J, Retz M, Harder J et al. Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis 2002;2:20.
22. Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun 2000;68:113-119.
23. Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002;347:1151-1160.
24. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells, multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000;68:2907-2915.
25. Jin EJ, Söder PÖ, Leung WK et al. Granulocyte elastase activity and PGE2 levels in gingival crevicular fluid in relation to the presence of subgingival periodontopathogens in subjects with untreated adult periodontitis. J Clin Periodontol 1999;26:531-540.
26. Kohlberger PD, Obermair A, Sliutz G et al. Quantitative immunohistochemistry of factor VIII-related antigen in breast carcinoma: a comparison of computer-assisted image analysis with established counting methods. Am J Clin Pathol 1996;105:705-710.
27. Consensus report. Periodontal diseases: pathogenesis and microbial factors. Ann Periodontol 1996;1:926-932.
28. Liu L, Wang L, Jia HP et al. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 1998;222:237-244.
29. Dunsche A, Acil Y, Siebert R, Harder J, Schröder JM, Jepsen S. Expression profile of human defensins and antimicrobial proteins in oral tissues. J Oral Pathol Med 2001;30:154-158.
30. Boman HG. Innate immunity and the normal microflora. Immunol Rev 2000;173:5-16.
31. Fehlbaum P, Rao M, Zasloff M, Anderson GM. An essential amino acid induces epithelial beta-defensin expression. Proc Natl Acad Sci USA 2000;97:12723-12728.
32. Liu AY, Destoumieux D, Wong AV et al. Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002;118:275-281.
33. Jin LJ, Söder B, Corbet EF. Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis. J Periodontol 2000;71:929-939.
34. Jin LJ, Leung WK, Corbet EF, Söder B. Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis. J Clin Periodontol 2002;29:604-614.
35. Islam D, Bandholtz L, Nilsson J et al. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001;7:180-185.