Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets

Intensive Care Medicine

Volumn 33, Issue 9, 2007, Pages 1594-1601

  Albert, Johanna ^a   Harbut, Piotr ^a   Zieliński, Stanisław ^b   Ryniak, Stanisław ^c   Gillis Haegerstrand, Caroline ^a   Lindwall, Robert ^a   Solski, Leszek ^b   Lundberg, Jon O ^d   Svensson, Jan ^c   Goździk, Waldemar ^b  

^a DANDERYD HOSPITAL   (Sweden)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adverse effects; Bleeding time; Haemostasis; Inhalation; Nitric oxide; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; D DIMER; NITRATE; NITRIC OXIDE; NITRITE; OXYGEN; PROTHROMBIN; PROTHROMBIN COMPLEX; TISSUE PLASMINOGEN ACTIVATOR;

ADVERSE OUTCOME; ANESTHESIA; ANIMAL EXPERIMENT; ARTERY CATHETER; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; BREATHING; CENTRAL VENOUS CATHETER; CONTROLLED STUDY; EXPERIMENTAL STUDY; EXPOSURE; FIBRIN FORMATION; FIBRINOLYSIS; HEMOSTASIS; INTUBATION; NONHUMAN; PIGLET; PRESSURE SUPPORT VENTILATION; THROMBOCYTE ADHESION; THROMBOCYTE FUNCTION; UNIVERSITY HOSPITAL; URINE CATHETER;

ADMINISTRATION, INHALATION; ANIMALS; ASPIRIN; BLEEDING TIME; BLOOD COAGULATION FACTORS; BODY TEMPERATURE; BRONCHODILATOR AGENTS; C-REACTIVE PROTEIN; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HEMOGLOBINS; HEMOSTASIS; LEUKOCYTE COUNT; NITRATES; NITRIC OXIDE; NITRITES; PEPTIDE FRAGMENTS; PLATELET AGGREGATION INHIBITORS; PROTEIN PRECURSORS; PROTHROMBIN; RANDOM ALLOCATION; SWINE;

EID: 34548176074     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0666-3     Document Type: Article

References (40)

1. Roberts JD, Polaner DM, Lang P, Zapol WM (1992) Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 340:818-819
2. Ninos (1997) Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med 336:597-604
3. Macrae DJ, Field D, Mercier JC, Moller J, Stiris T, Biban P, Cornick P, Goldman A, Gothberg S, Gustafsson LE, Hammer J, Lonnqvist PA, Sanchez-Luna M, Sedin G, Subhedar N (2004) Inhaled nitric oxide therapy in neonates and children: reaching a European consensus. Intensive Care Med 30:372-380
4. Lindwall R, Blennow M, Svensson M, Jonsson B, Berggren-Bostrom E, Flanby M, Lonnqvist PA, Frostell C, Norman M (2005) A pilot study of inhaled nitric oxide in preterm infants treated with nasal continuous positive airway pressure for respiratory distress syndrome. Intensive Care Med 31:959-964
5. Germann P, Braschi A, Della Rocca G, Dinh-Xuan AT, Falke K, Frostell C, Gustafsson LE, Herve P, Jolliet P, Kaisers U, Litvan H, Macrae DJ, Maggiorini M, Marczin N, Mueller B, Payen D, Ranucci M, Schranz D, Zimmermann R, Ullrich R (2005) Inhaled nitric oxide therapy in adults: European expert recommendations. Intensive Care Med 31:1029-1041
6. Hogman M, Frostell C, Arnberg H, Hedenstierna G (1993) Bleeding time prolongation and NO inhalation. Lancet 341:1664-1665
7. Albert J, Norman M, Wallen NH, Frostell C, Hjemdahl P (1999) Inhaled nitric oxide does not influence bleeding time or platelet function in healthy volunteers. Eur J Clin Invest 29:953-959
8. Malmros C, Blomquist S, Dahm P, Martensson L, Thorne J (1996) Nitric oxide inhalation decreases pulmonary platelet and neutrophil sequestration during extracorporeal circulation in the pig. Crit Care Med 24:845-849
9. Albert J, Wallen NH, Broijersen A, Frostell C, Hjemdahl P (1996) Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects. Clin Sci (Lond) 91:225-231
10. Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, Guillosson JJ, Coriat P, Rouby JJ (1995) Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 83:56-65
11. Lundin S, Mang H, Smithies M, Stenqvist O, Frostell C (1999) Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide. Intensive Care Med 25:911-919
12. Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, Cutter GR, Baier M, Abman SH (1999) Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 354:1061-1065
13. Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P (2003) Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med 349:2099-2107
14. Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Higgins RD, Oh W, Hudak ML, Laptook AR, Shankaran S, Finer NN, Carlo WA, Kennedy KA, Fridriksson JH, Steinhorn RH, Sokol GM, Konduri GG, Aschner JL, Stoll BJ, D'Angio CT, Stevenson DK (2005) Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 353:13-22
15. Radomski MW, Palmer RM, Moncada S (1990) An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87:5193-5197
16. Kelm M, Schrader J (1990) Control of coronary vascular tone by nitric oxide. Circ Res 66:1561-1575
17. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J (1992) Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 89:7674-7677
18. Stamler JS, Lamas S, Fang FC (2001) Nitrosylation: the prototypic redox-based signaling mechanism. Cell 106:675-683
19. Lecour S, Clermont G, du Toit E, Gilson L, Maupoil V, Lowe S, Dupuis P, Girard C, Rochette L (2003) Evidence for the extrapulmonary localization of inhaled nitric oxide. Heart Dis 5:372-377
20. Wraight WM, Young JD (2001) Renal effects of inhaled nitric oxide in humans. Br J Anaesth 86:267-269
21. Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, Petersson AS, Waagstein F (1993) Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73:1121-1127
22. Zhang H, Lindwall R, Zhu L, Frostell C, Sun B (2003) Lung physiology and histopathology during cumulated exposure to nitric oxide in combination with assisted ventilation in healthy piglets. Pulm Pharmacol Ther 16:163-169
23. Lundberg JO, Weitzberg E (2005) NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol 25:915-922
24. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, Lundberg JO (2005) The emerging biology of the nitrite anion. Nat Chem Biol 1:308-314
25. Webb A, Bond R, McLean P, Uppal R, Benjamin N, Ahluwalia A (2004) Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci USA 101:13683-13688
26. Albert JG, Zielinski W, Ryniak S, Lindwall S, Harbut R, Solski P, Kubler L, Frostell A (2005) Unchanged haemostasis in piglets during 30 hours exposure to inhaled nitric oxide. American Thoracic Society 2:A557
27. Munster AM, Olsen AK, Bladbjerg EM (2002) Usefulness of human coagulation and fibrinolysis assays in domestic pigs. Comp Med 52:39-43
28. Lundberg JO, Govoni M (2004) Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 37:395-400
29. Rao AK, Ghosh S, Sun L, Yang X, Disa J, Pickens P, Polansky M (1995) Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial. Thromb Haemost 74:1071-1078
30. Ferraris VA, Berry W, Lough F (1987) Routine template bleeding time determinations before cardiac procedures. J Thorac Cardiovasc Surg 93:474-476
31. Rodgers RP, Levin J (1990) Bleeding time: a guide to its diagnostic and clinical utility. Arch Pathol Lab Med 114:1187-1188
32. Albert J (1999) Effects of nitric oxide on hemostasis with special attention to platelet function (PhD thesis). Karolinska Institutet, Stockholm, p 970
33. Lilienberg G, Venge P (1998) Platelet adhesion in patients prone to arterial and venous thrombosis: the impact of gender, smoking and heredity. Scand J Clin Lab Invest 58:279-286
34. Bierbach B, Horstick G, Berg O, Heimann A, Munzel T, Vahl CF, Kempski O, Darius H (2006) Potent low dose platelet inhibitory effects of clopidogrel and aspirin on coronary thrombus formation in an animal model of acute unstable angina. Thromb Haemost 95:354-361
35. Claeys MJ, Van Der Planken MG, Michiels JJ, Vertessen F, Dilling D, Bosmans JM, Vrints CJ (2002) Comparison of antiplatelet effect of loading dose of clopidogrel versus abciximab during coronary intervention. Blood Coagul Fibrinolysis 13:283-288
36. Gries A, Bode C, Peter K, Herr A, Bohrer H, Motsch J, Martin E (1998) Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation 97:1481-1487
37. George TN, Johnson KJ, Bates JN, Segar JL (1998) The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 132:731-734
38. Wennmalm A, Benthin G, Petersson AS (1992) Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin. Br J Pharmacol 106:507-508
39. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ (2005) Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest 115:1232-1240
40. Biban P, Zangardi T, Baraldi E, Dussini N, Chiandetti L, Zacchello F (2001) Mixed exhaled nitric oxide and plasma nitrites and nitrates in newborn infants. Life Sci 68:2789-2797