Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects

Clinical Science

Volumn 91, Issue 2, 1996, Pages 225-231

  Albert, Johanna ^b   Wallén, N Håkan ^b   Bröijersén, Anders ^b   Frostell, Claes ^b   Hjemdahl, Paul ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Bleeding time; cGMP; Nitric oxide (inhaled); Platelet aggregation

Indexed keywords

ACETYLSALICYLIC ACID; CYCLIC GMP; GUANYLATE CYCLASE; NITRIC OXIDE;

ARTICLE; BLEEDING TIME; CELL FUNCTION; HUMAN; HUMAN CELL; INHALATIONAL DRUG ADMINISTRATION; LUNG DISEASE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE RELEASE REACTION;

EID: 0029773512     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0910225     Document Type: Article

References (31)

1. Rossaint R, Falke K, Lopez F, Slama K, Pison U, Zapol W. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993; 328: 399-405.
2. Kinsella J, Neish S, Shaffer E, Abman S. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340: 819-20.
3. Rimar S, Gillis CN. Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation. Circulation 1993; 88: 2884-7.
4. Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987; 148: 1482-9.
5. Radomski MW, Palmer RM, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U.S.A. 1990; 87: 5193-7.
6. Nathan C, Qiao-wen X. Nitric oxide synthases: roles, tolls, and controls. Cell 1994; 78: 915-18.
7. Seamler JS, Loscalzo J. The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J Am Coll Cardiol 1991; 18: 1529-36.
8. Langford EJ, Brown AS, Wainwright RJ, et al. Inhibition of platelet activity by S-nitrosogluiathione during coronary angioplasty. Lancet 1994; 344: 1458-60.
9. Rodgers RPC, Levin J. A critical reappraisal of bleeding time. Semin Thromb Haemost 1990; 16: 1-20.
10. Högman M, Frostell C, Arnberg H, Sandhagen B, Hedenstierna G. Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 1994; 151: 125-9.
11. Högman M, Frostell C, Arnberg H, Hedenstierna G. Bleeding time prolongation and NO inhalation [Letter]. Lancet 1993; 341: 1664-5.
12. Gries A, Motsch J, Penk S, Bauer H, Weimann J, Martin E. Sex-dependent differences in bleeding time prolongation under inhaled nitric oxide. Br J Anaesth 1995; 74 (Suppl. A): 407.
13. Samama CM, Diaby M, Fellahi JL, et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1995; 83: 56-65.
14. Hornstra G, ten Hoor F. The filtragometer: a new device for measuring platelet aggregation in venous blood of man. Thromb Diath Haemorrh 1975; 34: 531-44.
15. Larsson PT, Hjemdahl P, Olsson G, Egberg N, Hornstra G. Altered platelet function during mental stress and adrenalin infusion in humans: evidence for an increased aggregability in vivo as measured by filtragometry. Clin Sci 1989; 76: 369-76.
16. Larsson PT, Wallén NH, Hjemdahl P. Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation 1994; 89: 1951-7.
17. Wallen NH, Held C, Rehnqvist N, Hjemdahl P. Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris. Am J Cardiol 1995; 75: 1-6.
18. Beck O, Wallén NH, Bröijersén A, Larsson PT, Hjemdahl P. On the accurate determination of serotonin in human plasma. Biochem Biophys Res Commun 1993; 196: 260-6.
19. Stenqvist O, Kjelltoft B, Lundin S. Evaluation of a new system for ventilatory administration of nitric oxide. Acta Anaesth Scand 1993; 37: 687-91.
20. Karlberg KE, Ahlner J, Henriksson P, Torfgård K, Sylvén C. Effects of nitroglycerin on platelet aggregation beyond the effects of acetylsalicylic acid in healthy subjects. Am J Cardiol 1993; 71: 361-4.
21. De Caterina R, Lanza M, Manca G, Buti Strata G, Maffei S, Salvatore L. Bleeding time and bleeding: an analysis of the relationship of bleeding time test with parameters of surgical bleeding. Blood 1994; 84: 3363-70.
22. Hjemdahl P, Perneby C, Theodorson E, Egberg N, Larsson PT. A new assay for β-thromboglobulin in urine. Thromb Res 1991; 64: 33-43.
23. Hjemdahl P. Catecholamine measurements in plasma by high-performance liquid chromatography with electrochemical detection. Methods Enzymol 1987; 142: 521-34.
24. Krejcy K, Schmetterer L, Kastner J, et al. Role of nitric oxide in hemostatic system activation in vivo in humans. Art Thromb Vasc Biol 1995; 15: 2063-7.
25. Larsson PT, Wallén NH, Martinsson A, Egberg N, Hjemdahl P. Significance of platelet β-adrenoceptors for platelet responses in vivo and in vitro. Thromb Haemost 1992; 68: 687-93.
26. Söderbäck U, Sollevi A, Wallén H, Larsson PT, Hjemdahl P. Antiaggregatory effects of physiological adenosine concentrations in human whole blood, as assessed by filtragometry. Clin Sci 1991; 81: 691-4.
27. Rovira I, Chen TY, Winkler M, Kawai N, Bloch KD, Zapol WM. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol 1994; 76: 345-55.
28. Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Circulation 1993; 88: 2128-38.
29. Stamler JS, Simon DI, Osborne JA, et al. S-Nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci U.S.A. 1992; 89: 444-8.
30. Greene R, Boggis CRM, Jantsch HS. Radiography and angiography of the pulmonary circulation in ARDS. In: Zapol WM, Falke KJ, eds. Acute respiratory failure. New York: Marcel Dekker, 1985: 275-302.
31. Carvalho A. Blood alterations in ARDS. In: Zapol WM, Falke KJ, eds. Acute respiratory failure. New York: Marcel Dekker, 1985: 303-46.