Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatography-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 856, Issue 1-2, 2007, Pages 302-311

  Patel, Kashyap ^a   Lewiston, David ^b   Gu, Yongchuan ^a   Hicks, Kevin O ^a   Wilson, William R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b MicroConstants 9050 Camino Santa Fe   (United States)

Author keywords

Metabolite identification; Nitrogen mustards; PR 104; PR 104A; Prodrugs

Indexed keywords

HYPOXIC TUMOUR CELLS; NITROGEN MUSTARDS; PRODRUGS;

AMIDES; CYTOTOXICITY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN);

DRUG PRODUCTS;

2 (2 BROMOETHYL) 2 [[(2 HYDROXYETHYL)AMINOCARBONYL] 4, 6 DINITROANALINO]ETHYLMETHANESULFONATE PHOSPHATE ESTER; BENZAMIDE DERIVATIVE; DINITROBENZAMIDE MUSTARD; DRUG METABOLITE; PR 104; PR 104A; PRODRUG; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG TISSUE LEVEL; FEMALE; HUMAN; HYDROLYSIS; HYPOXIA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; TUMOR XENOGRAFT; VALIDATION PROCESS;

ANIMALS; ANOXIA; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MICE; NITROGEN MUSTARD COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

BRASSICACEAE; CANIS FAMILIARIS; RATTUS;

EID: 34548140058     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.06.035     Document Type: Article

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