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Volumn 50, Issue 1, 2007, Pages 7-12
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Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-((2-bromoethyl)-2,4-dinitro-6-(((2- (phosphonooxy)ethyl)amino)carbonyl)anilino)ethyl methanesulfonate (PR-104)
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Author keywords
Deuterium; Dinitrobenzamide mustard; Hypoxia activated prodrug; PR 104; Tritium
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Indexed keywords
SODIUM BOROHYDRIDE;
TRITIUM;
% REDUCTIONS;
DINITROBENZAMIDE MUSTARD;
ETHYL METHANESULFONATE;
HYPOXIA-ACTIVATED PRODRUG;
LATE STAGE;
PR-104;
PRODRUGS;
SIDE-CHAINS;
[CARBONYL;
DEUTERIUM;
2 [( BROMOETHYL) 2,4 DINITRO 6 [[( 2 OXOETHYL)AMINO]CARBONYL]ANILINO]ETHYL METHANESULFONATE;
2 [( BROMOETHYL) 2,4 DINITRO 6 [[[2 PHOSPHONOXY (1,1,2,2)ETHYL] AMINO]CARBONYL]ANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) (2 (9METHYLSULFONYL)OXY)ETHYL)AMINO] 3,5 DINITROBENZOIC ACID;
2 [(2 BROMOETHYL) 2 (6 TERT BUTOXY 8,8 DIMETHYL 6 OXIDO 5,7 DIOXA 2 AZA 6 PHOSPHANON 1 ANOYL) 4,6 DINITROANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) 2 [(3,3,4,4) 6 TERT BUTOXY 8,8 DIMETHYL 6 OXIDO 5,7 DIOXA 2 AZA 6 PHOSPHANON 1 ANOYL] 4,6 DINITROANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) 2 [[( 2 HYDROXYETHYL)AMINO]CARBONYL]4,6 DINITROANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) 2 [[[2 HYDROXY(1,1,2,2)ETHYL] AMINO]CARBONYL] 4,6 DINITROANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) 2,4 DINITRO 6 [[[ 2(PHOSPHONOOXY)ETHYL] AMINO]CARBONYL]ANILINO]ETHYL METHANESULFONATE;
2 [(2 BROMOETHYL) 2,4 DINITRO 6 [[[2 (PHOSPHONOOXY)ETHYL]AMINO]CARBONYL]ANILINO]ETHYL METHANESULFONATE;
AMIDE;
DEUTERIUM;
ETHYLCARBOXAMIDE;
MESYLIC ACID DERIVATIVE;
PR 104;
TERT BUTYL 2 (BIS(2 HYDROXYETHYL)AMINO) 3,5 DINITROBENZOATE;
TERT BUTYL 2 [(2 BROMOETHYL) (2 ((METHYLSULFONYL)OXY)ETHYL)AMINO] 3,5 DINITROBENZOATE;
TERT BUTYL 2 [BIS(2 ((METHYLSULFONYL0OXY)ETHYL)AMINO] 3,5 DINITROBENZOATE;
TRITIUM;
UNCLASSIFIED DRUG;
ARTICLE;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HYPOXIA;
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EID: 33947403889
PISSN: 03624803
EISSN: 10991344
Source Type: Journal
DOI: 10.1002/jlcr.1147 Document Type: Article |
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Times cited : (30)
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References (5)
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