Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal

Experimental Hematology

Volumn 35, Issue 9, 2007, Pages 1447-1455

  Tong, Wei ^a   Ibarra, Yessenia M ^a   Lodish, Harvey F ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BOX1 PROTEIN; BOX2 PROTEIN; JANUS KINASE 2; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MP1 PROTEIN; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44; STAT3 PROTEIN; STAT5 PROTEIN; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL ACTIVITY; CELL CULTURE; CELL FUNCTION; CELL MATURATION; CELL MEMBRANE; CELL RENEWAL; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; GENE DELETION; HEMATOPOIETIC STEM CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL MEMBRANE; GENE DELETION; HEMATOPOIETIC STEM CELLS; MICE; MICE, KNOCKOUT; RECEPTORS, THROMBOPOIETIN; SIGNAL TRANSDUCTION;

MUS;

EID: 34548129976     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.05.010     Document Type: Article

References (28)

1. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 86 (1995) 419-431
2. Kaushansky K. Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 1 (2003) 1587-1592
3. Gurney A.L., Carver-Moore K., de Sauvage F.J., and Moore M.W. Thrombocytopenia in c-mpl-deficient mice. Science 265 (1994) 1445-1447
4. de Sauvage F.J., Carver-Moore K., Luoh S.M., et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 183 (1996) 651-656
5. Alexander W.S., Roberts A.W., Nicola N.A., Li R., and Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87 (1996) 2162-2170
6. Carver-Moore K., Broxmeyer H.E., Luoh S.M., et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice. Blood 88 (1996) 803-808
7. Kimura S., Roberts A.W., Metcalf D., and Alexander W.S. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A 95 (1998) 1195-1200
8. Solar G.P., Kerr W.G., Zeigler F.C., et al. Role of c-mpl in early hematopoiesis. Blood 92 (1998) 4-10
9. Fox N., Priestley G., Papayannopoulou T., and Kaushansky K. Thrombopoietin expands hematopoietic stem cells after transplantation. J Clin Invest 110 (2002) 389-394
10. Abkowitz J.L., and Chen J. Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Blood (2007) Epub ahead of print
11. Watowich S.S., Wu H., Socolovsky M., Klingmuller U., Constantinescu S.N., and Lodish H.F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol 12 (1996) 91-128
12. Drachman J.G., and Kaushansky K. Structure and function of the cytokine receptor superfamily. Curr Opin Hematol 2 (1995) 22-28
13. Parganas E., Wang D., Stravopodis D., et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93 (1998) 385-395
14. Luoh S.M., Stefanich E., Solar G., et al. Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo. Mol Cell Biol 20 (2000) 507-515
15. Gurney A.L., Wong S.C., Henzel W.J., and de Sauvage F.J. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK- STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci U S A 92 (1995) 5292-5296
16. Drachman J.G., and Kaushansky K. Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc Natl Acad Sci U S A 94 (1997) 2350-2355
17. Pestina T.I., Cleveland J.L., Yang C., Zambetti G.P., and Jackson C.W. Mpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis. Blood 98 (2001) 2084-2090
18. Pestina T.I., and Jackson C.W. Differential role of Stat5 isoforms in effecting hematopoietic recovery induced by Mpl-ligand in lethally myelosuppressed mice. Exp Hematol 31 (2003) 1198-1205
19. Tong W., and Lodish H.F. Lnk Inhibits Tpo-mpl Signaling and Tpo-mediated Megakaryocytopoiesis. J Exp Med 200 (2004) 569-580
20. Arriaga M., South K., Cohen J.L., and Mazur E.M. Interrelationship between mitosis and endomitosis in cultures of human megakaryocyte progenitor cells. Blood 69 (1987) 486-492
21. Tong W., Zhang J., and Lodish H.F. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105 (2005) 4604-4612
22. Zang H., Sato K., Nakajima H., McKay C., Ney P.A., and Ihle J.N. The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J 20 (2001) 3156-3166
23. Li K., Menon M.P., Karur V.G., Hegde S., and Wojchowski D.M. Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells. Blood 102 (2003) 3147-3153
24. Drachman J.G., Miyakawa Y., Luthi J.N., et al. Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation. J Biol Chem 277 (2002) 23544-23553
25. Joneja B., and Wojchowski D.M. Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain. J Biol Chem 272 (1997) 11176-11184
26. Miura O., Miura Y., Nakamura N., et al. Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 84 (1994) 4135-4141
27. Harder K.W., Quilici C., Naik E., et al. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104 (2004) 3901-3910
28. Lannutti B.J., and Drachman J.G. Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103 (2004) 3736-3743