Promoter methylation downregulates CDX2 expression in colorectal carcinomas

Oncology Reports

Volumn 13, Issue 3, 2005, Pages 547-551

  Kawai, Hiroshi ^a   Tomii, Kunitoshi ^a   Toyooka, Shinichi ^a   Yano, Masaaki ^a   Murakami, Masakazu ^a   Tsukuda, Kazunori ^a   Shimizu, Nobuyoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Caudal type homeobox transcription factor 2; Colorectal carcinoma; DNA methylation

Indexed keywords

CDX 2 3 PROTEIN; CDX-2-3 PROTEIN; HOMEODOMAIN PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CARCINOMA; CELL CULTURE; COLORECTAL TUMOR; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; POINT MUTATION; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CARCINOMA; COLORECTAL NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; POINT MUTATION; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 15044346790     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.13.3.547     Document Type: Article

References (21)

1. Potter JD: Colorectal cancer: molecules and populations. J Natl Cancer Inst 91: 916-932, 1999.
2. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN and Srivastava S: A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58: 5248-5257, 1998.
3. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB and Issa JP: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 96: 8681-8686, 1999. (Pubitemid 29354851)
4. Toyooka S, Toyooka KO, Maruyama R, Virmani AK, Girard L, Miyajima K, Harada K, Ariyoshi Y, Takahashi T, Sugio K, Brambilla E, Gilcrease M, Minna JD and Gazdar AF: DNA methylation profiles of lung tumors. Mol Cancer Ther 1: 61-67, 2001.
5. Jammes R, Erler T and Kazenwadel J: Structure of the murine homeobox gene cdx-2. J Biol Chem 269: 15229-15237, 1994.
6. Silberg DG, Swain GP, Shu ER and Traber PG: Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 119: 961-971, 2000.
7. Kaimaktchiev V, Terracciano L, Tornillo L, Spichtin H, Stoios D, Bundi M, Korcheva V, Mirlacher M, Loda M, Sauter G and Corless CL: The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. Mod Pathol (In press).
8. Sivagnanasundaram S, Islam I, Talbot I, Drummond F, Walters JR and Edwards YH: The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis. Br J Cancer 84: 218-225, 2001. (Pubitemid 32113449)
9. Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC and Iovanna JL: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox, down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74: 35-44, 1997. (Pubitemid 27157853)
10. Werling RW, Yaziji H, Bacchi CE and Gown AM: CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27: 303-310, 2003. (Pubitemid 36245795)
11. Hinoi T, Loda M and Fearon ER: Silencing of CDX2 expression in colon cancer via a dominant repression pathway. J Biol Chem 278: 44608-44616, 2003. (Pubitemid 37377215)
12. Suh ER, Ha CS, Rankin EB, Toyota M and Traber PG: DNA methylation down-regulates CDX1 sene expression in colorectal cancer cell lines. J Biol Chem 277: 35795-35800, 2002.
13. Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL and Bodmer WF: Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc Natl Acad Sci USA 101: 574-579, 2004. (Pubitemid 38084678)
14. Dote H, Toyooka S, Tsukuda K, Yano M, Ouchida M, Doihara H, Suzuki M, Chen H, Hsieh JT, Gazdar AF and Shimizu N: Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clin Cancer Res 10: 2082-2089, 2004. (Pubitemid 38375570)
15. Seno H, Oshima M, Taniguchi M, Usami K, Ishikawa T, Chiba T and Taketo MM: CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. Int J Oncol 21: 769-774, 2002.
16. Mizoshita T, Tsukamoto T, Inada K, Ogasawara N, Hirata A, Kato S, Joh T, Itoh M, Yamamura Y and Tatematsu M: Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa. Pathol Int 54: 392-400, 2004. (Pubitemid 38829924)
17. Phillips RW, Frierson HF Jr and Moskaluk CA: Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 27: 1442-1447, 2003. (Pubitemid 37315196)
18. Li MK and Folpe AL: CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv Anat Pathol 11: 101-105, 2004.
19. Barbareschi M, Murer B, Colby TV, Chilosi M, Macri E, Loda M and Doglioni C: CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs. Am J Surg Pathol 27: 141-149, 2003. (Pubitemid 36152222)
20. Bai YQ, Miyake S, Iwai T and Yuasa Y: CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 22: 7942-7949, 2003. (Pubitemid 37175859)
21. Hinoi T, Lucas PC, Kuick R, Hanash S, Cho KR and Fearon ER: Related CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 123: 1565-1577, 2002. (Pubitemid 35231656)