메뉴 건너뛰기




Volumn 35, Issue 9, 2007, Pages 1611-1616

Decrease in plasma concentrations of antiangiogenic agent TSU-68 ((Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3- propanoic acid) during oral administration twice a day to rats

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ANGIOGENESIS INHIBITOR; OXIDOREDUCTASE;

EID: 34548093853     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.014068     Document Type: Article
Times cited : (13)

References (25)
  • 1
    • 0037465153 scopus 로고    scopus 로고
    • Validation of liquid chromatography assay for the quantitation of (Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl) -1H-pyrrol-3-yl]propionic acid (SU006668) in human plasma and its application to a phase I clinical trial
    • Asad Y, Cropp G, Adams A, O'Donnell A, Raynaud F, Judson I, and Workman P (2003) Validation of liquid chromatography assay for the quantitation of (Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl) -1H-pyrrol-3-yl]propionic acid (SU006668) in human plasma and its application to a phase I clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci 785:175-186.
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.785 , pp. 175-186
    • Asad, Y.1    Cropp, G.2    Adams, A.3    O'Donnell, A.4    Raynaud, F.5    Judson, I.6    Workman, P.7
  • 3
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N (1999) Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77:527-543.
    • (1999) J Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 4
    • 0032927254 scopus 로고    scopus 로고
    • Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications
    • Fleisher D, Li C, Zhou Y, Pao LH, and Karim A (1999) Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications. Clin Pharmacokinet 36:233-254.
    • (1999) Clin Pharmacokinet , vol.36 , pp. 233-254
    • Fleisher, D.1    Li, C.2    Zhou, Y.3    Pao, L.H.4    Karim, A.5
  • 5
    • 0033556802 scopus 로고    scopus 로고
    • Signal transduction by fibroblast growth factor receptors
    • Klint P and Claesson-Welsh L (1999) Signal transduction by fibroblast growth factor receptors. Front Biosci 4:165-177.
    • (1999) Front Biosci , vol.4 , pp. 165-177
    • Klint, P.1    Claesson-Welsh, L.2
  • 6
    • 24344465796 scopus 로고    scopus 로고
    • Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies
    • Kuenen BC, Giaccone G, Ruijter R, Kok A, Schalkwijk C, Hoekman K, and Pinedo HM (2005) Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies. Clin Cancer Res 11:6240-6246.
    • (2005) Clin Cancer Res , vol.11 , pp. 6240-6246
    • Kuenen, B.C.1    Giaccone, G.2    Ruijter, R.3    Kok, A.4    Schalkwijk, C.5    Hoekman, K.6    Pinedo, H.M.7
  • 7
    • 0033567424 scopus 로고    scopus 로고
    • Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of δ-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats
    • Iba MM, Alam J, Touchard C, Thomas PE, Ghosal A, Fung J (1999) Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of δ-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats. Biochem Pharmacol 58:723-734.
    • (1999) Biochem Pharmacol , vol.58 , pp. 723-734
    • Iba, M.M.1    Alam, J.2    Touchard, C.3    Thomas, P.E.4    Ghosal, A.5    Fung, J.6
  • 8
    • 0036304016 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between herbal remedies and medicinal drugs
    • Ioannides C (2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:451-478.
    • (2002) Xenobiotica , vol.32 , pp. 451-478
    • Ioannides, C.1
  • 10
    • 1242269897 scopus 로고    scopus 로고
    • Rifampicin reduces plasma concentrations of celiprolol
    • Lilja JJ, Niemi M, and Neuvonen PJ (2004) Rifampicin reduces plasma concentrations of celiprolol. Eur J Clin Pharmacol 59:819-824.
    • (2004) Eur J Clin Pharmacol , vol.59 , pp. 819-824
    • Lilja, J.J.1    Niemi, M.2    Neuvonen, P.J.3
  • 11
    • 33745395225 scopus 로고    scopus 로고
    • CYP induction-mediated drug interactions: In vitro assessment and clinical implications
    • Lin JH (2006) CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res (NY) 23:1089-1116.
    • (2006) Pharm Res (NY) , vol.23 , pp. 1089-1116
    • Lin, J.H.1
  • 12
    • 0141765335 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and biological studies of TSU-68, the oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, administered after meals in patients with advanced solid tumors
    • Abstract 870
    • Murakami H, Yamamoto N., Shimoyama T, Ueda Y, Yamada Y, and Tamura T (2003) Phase I, pharmacokinetic, and biological studies of TSU-68, the oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, administered after meals in patients with advanced solid tumors. Proc Am Soc Clin Oncol 22:Abstract 870.
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Murakami, H.1    Yamamoto, N.2    Shimoyama, T.3    Ueda, Y.4    Yamada, Y.5    Tamura, T.6
  • 13
    • 0034029871 scopus 로고    scopus 로고
    • Auto-induction of E5110 metabolism, a novel non-steroidal anti-inflammatory drug, during toxicokinetic studies in beagle dogs
    • Nakata H, Sagami F, and Horie T (2000) Auto-induction of E5110 metabolism, a novel non-steroidal anti-inflammatory drug, during toxicokinetic studies in beagle dogs. J Toxicol Sci 25:1-10.
    • (2000) J Toxicol Sci , vol.25 , pp. 1-10
    • Nakata, H.1    Sagami, F.2    Horie, T.3
  • 15
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
    • Obach RS (1999) Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350-1359.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 17
    • 0032462002 scopus 로고    scopus 로고
    • Evidence for distinct signaling properties and biological responses induced by the PDGF receptor α and β subtypes
    • Rosenkranz S and Kazlauskas A (1999) Evidence for distinct signaling properties and biological responses induced by the PDGF receptor α and β subtypes. Growth Factors 16:201-216.
    • (1999) Growth Factors , vol.16 , pp. 201-216
    • Rosenkranz, S.1    Kazlauskas, A.2
  • 20
    • 33646801604 scopus 로고    scopus 로고
    • Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)- 4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes
    • Shimizu T, Akimoto K, Yoshimura T, Niwa T, Kobayashi K, Tsunoo M, and Chiba K (2006) Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)- 4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes. Drug Metab Dispos 34:950-954.
    • (2006) Drug Metab Dispos , vol.34 , pp. 950-954
    • Shimizu, T.1    Akimoto, K.2    Yoshimura, T.3    Niwa, T.4    Kobayashi, K.5    Tsunoo, M.6    Chiba, K.7
  • 21
    • 0031748173 scopus 로고    scopus 로고
    • In vitro and in vivo drug interactions involving human CYP3A
    • Thummel KE and Wilkinson GR (1998) In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 38:389-430.
    • (1998) Annu Rev Pharmacol Toxicol , vol.38 , pp. 389-430
    • Thummel, K.E.1    Wilkinson, G.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.