Auto-induction of E5110 metabolism, a novel non-steroidal anti- inflammatory drug, during toxicokinetic studies in beagle dogs

Journal of Toxicological Sciences

Volumn 25, Issue 1, 2000, Pages 1-10

  Nakata, Hiroshi ^a   Sagami, Fumio ^a   Horie, Toni ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Auto induction; CYP2B; CYP3A; E5110; Sex related differences; Toxicokinetics

Indexed keywords

3 (3,5 DI TERT BUTYL 4 HYDROXYBENZYLIDENE) 1 METHOXY 2 PYRROLIDINONE; 4 NITROANISOLE DEMETHYLASE; AMINOPYRINE N DEMETHYLASE; BENZPHETAMINE; CYTOCHROME P450 3A; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG CLEARANCE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; SEX DIFFERENCE; TOXICITY TESTING; TOXICOKINETICS; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

ANIMALIA; CANIS FAMILIARIS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034029871     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.25.1     Document Type: Article

References (15)

1. Gad, S. and Weil, C. S. (1982): Statistics for toxicologist. In principles and methods of toxicology (Wallance, H. A. ed.), pp. 273-320. Raven Press, New York.
2. Ged, C., Rouillon, J. M., Pichard, L., Combalbert, J., Bressot, N., Bories, P., Michel, H., Beaune, P. and Maurel, P. (1989): The increase in urinary excretion of 6β-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction. Br. J. Clin. Pharmacol., 28, 373-387.
3. Guengerich, F. P., Wang, P. and Davidson, N. K. (1982): Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry, 21, 1698-1706.
4. Horie, T., Nakata, H. and Kusube, K. (1996): Basic strategy for avoiding drug interaction during stage of drug development. The proposals relative to planning of non-clinical and clinical studies how should it be the planning of clinical trials. J. Toxicol. Sci., 21, 331-339.
5. Imai, Y., Ito, A. and Sato, R. (1966): Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Biochem., 60, 417-428.
6. Kamataki, T., Kitada, M., Shigematsu, H. and Kitagawa, H. (1979): The involvement of cytochrome P-448 and P-450 in NADH-dependent O-desmethylation of p-nitroanisole in rat liver microsomes. Jap. J. Pharmacol., 29, 191-201.
7. Katayama, K., Shirota, H., Kobayashi, S., Terato, K., Ikuta, H. and Yamatsu, I. (1987): In vitro effect of N-methoxy-3-(3.5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent, on generation of some inflammatory mediators. Agents Action, 21, 269-271.
8. Laemmli, U. K. (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond), 227, 680-685.
9. Lin, J. H., Chiba, M., Chen, I. W., Nishime, J. A. and Vastag, K. J. (1996): Sex-dependent pharmacokinetics of indinavir. In vivo and in vitro evidence. Drug Metab. Dispos., 24, 1298-1306.
10. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 55, 265-275
11. Nash, T. (1953): The colorimetric estimation of formaldehyde by means of the hantzsch reaction. Biochem. J., 55, 416-421.
12. Nishibe, Y. and Hirata, M. (1995): Induction of cytochrome P450 3A(CYP 3A) by E5110, a nonsteroidal anti-inflammatory agent(NSATD), and typical CYP 3A inducers in primary cultures of dog hepatocytes. Biol. Pharm. Bull., 18, 1142-1144.
13. Omura, T. and Sato, R. (1964): The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J.Biol.Chem., 239, 2370-2378.
14. Smith, B. J., Zupan, L. A., Hu, J. K., Diters, R. W., Gibson, G. W. and Norton, J. N. (1996): Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog. Drug Metab. Dispos., 24, 523-528.
15. Yamaoka, K., Tanigawara, Y., Nakagawa, T. and Uno, T. (1981): A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharm. Dyn., 4, 879-885.