Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of δ-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats

Biochemical Pharmacology

Volumn 58, Issue 4, 1999, Pages 723-734

  Iba, Michael M ^a,c   Alam, Jawed ^b   Touchard, Cheri ^b   Thomas, Paul E ^a   Ghosal, Anima ^a   Fung, Jacqueline ^a  

^a RUTGERS UNIVERSITY   (United States)

^b OCHSNER MEDICAL CENTER   (United States)

^c EOHSI   (United States)

Author keywords

Aminolevulinic acid synthase; CYP1A1; Heme metabolism; HO 1; Lipid peroxidation; Pyridine; Tryptophan pyrrolase

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; CYTOCHROME P450 ISOENZYME; HEME; HEME OXYGENASE; MESSENGER RNA; PYRIDINE; TRYPTOPHAN 2,3 DIOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; HEME SYNTHESIS; KIDNEY; LIPID PEROXIDATION; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

5-AMINOLEVULINATE SYNTHETASE; ANIMALS; CYTOCHROME P-450 CYP1A1; ENZYME ACTIVATION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MALE; MICROSOMES, LIVER; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRYPTOPHAN OXYGENASE; UP-REGULATION;

EID: 0033567424     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00137-9     Document Type: Article

References (51)

1. International Agency for Research on Cancer, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man: Tobacco Smoking. IARC Monographs, Vol. 38. IARC, Lyon, France, 1986.
2. ATSDR, Toxicological Profile for Pyridine, TP-91/24. U.S. Department of Health and Human Services, PHS, Agency for Toxic Substances and Disease Registry, Atlanta, GA, 1992.
3. Kim S.G., Reddy S., States J.C., Novak R.F. Pyridine effects on expression and molecular regulation of the cytochrome P450IA gene family. Mol Pharmacol. 40:1991;52-57.
4. Iba M.M., Bennett S., Storch A., Thomas P.E. Synergistic induction of CYP1A1 and CYP1A2 by acetone in combination with pyridine. Cancer Lett. 74:1993;69-74.
5. Kim H., Putt D., Reddy S., Hollenberg P.F., Novak R.F. Enhanced expression of rat hepatic CYP2B1/2B2 and 2E1 by pyridine Differential induction kinetics and molecular basis of expression . J Pharmacol Exp Ther. 267:1993;927-936.
6. Kim S.G., Williams D.E., Schuetz E.G., Guzelian P.S., Novak R.F. Pyridine induction of cytochrome P-450 in the rat Role of P-450j (alcohol inducible form) in pyridine N-oxidation . J Pharmacol Exp Ther. 246:1988;1175-1182.
7. Iba M.M., Scholl H., Fung J., Thomas P.E., Alam J. Induction of pulmonary CYP1A1 by nicotine. Xenobiotica. 28:1998;827-843.
8. Kleman M., Overvik E., Mason G., Gustafsson J.-A. Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats. Carcinogenesis. 11:1990;2185-2189.
9. Iba M.M., Thomas P.E., Fung J. Comparative expression of CYP1A and lipid peroxidation and enzymes of heme metabolism in rats exposed to pyridine alone or with acetone. Fundam Appl Toxicol. 36:(Suppl):1997;84.
10. Baxter J.H. Hepatic and renal injury with calcium deposits and cirrhosis produced in rats by pyridine. Am J Pathol. 24:1948;503-525.
11. Pinsky C., Bose R. Pyridine and other coal tar constituents as free radical-generating environmental neurotoxicants. Mol Cell Biochem. 84:1988;217-222.
12. Ma M., Eaton J.W. Oxidative stress genes and proteins Fire alarms and fire extinguishers . Davis K.J.A. Oxidative Damage and Repair. Chemical, Biological and Medical Aspects. 1991;1-4 Pergamon Press, New York.
13. Stocker R. Induction of heme oxygenase as a defense against oxidative stress. Free Radic Res Commun. 9:1990;101-112.
14. Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem. 239:1964;2370-2378.
15. Bhat G.J., Padmanaban G. Heme is a positive regulator of cytochrome P450 gene transcription. Arch Biochem Biophys. 264:1988;584-590.
16. Tenhunen R., Marver H.S., Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA. 61:1968;748-755.
17. Maines MD, Heme Oxygenase. Clinical Applications and Functions. CRC Press, Boca Raton, 1993.
18. Moore M.R., McColl K.E.L., Rimington C., Goldberg A. Disorders of Porphyrin Metabolism. 1987;Plenum Publishing Co, New York.
19. Kappas A., Sassa S., Galbraith R.A., Nordmann Y. The porphyrias. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The Metabolic and Molecular Basis of Inherited Disease. 1995;2103-2158 McGraw-Hill, New York.
20. Feigelson M., Greengard O. A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase. J Biol Chem. 236:1961;153-157.
21. Badawy A.A.-B., Evans M. Regulation of rat liver tryptophan pyrrolase by its cofactor haem Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms . Biochem J. 150:1975;511-520.
22. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. Bilirubin is an antioxidant of possible physiological significance. Science. 235:1987;1043-1056.
23. Sinal C.J., Bend J.R. Aryl hydrocarbon receptor-dependent induction of Cyp1a1 by bilirubin in mouse hepatoma Hepa 1c1c7 cells. Mol Pharmacol. 52:1997;590-599.
24. Lu A.Y.H., Jacobson M., Poyer J.L., McCay P.B. Lipid peroxidation and the degradation of cytochrome P-450 heme. Arch Biochem Biophys. 158:1973;842-852.
25. Carlson G.P. Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicol Lett. 85:1966;173-178.
26. Iba M.M., Thomas P.E. Hepatic activation of dichlorobenzidine Involvement of cytochrome P-450d . Carcinogenesis. 2:1988;718-725.
27. Thomas P.E., Reik L.M., Ryan D.E., Levin W. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes. J Biol Chem. 259:1984;3890-3899.
28. Iba M.M., Alam J. Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3′-dichlorobenzidine and some other inducers of P450. Redox Rep. 1:1995;279-286.
29. Sambrook J, Fritsch EF and Maniatis T, Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
30. ISF/BNF-G. Arch Biochem Biophys. 244:1985;261-272.
31. Alam J., Shibahara S., Smith A. Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells. J Biol Chem. 264:1989;6371-6375.
32. Pohl R.J., Fouts J.R. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal cellular fractions. Anal Biochem. 107:1980;150-155.
33. Marver H.S., Tschudy D.P., Perlroth M.G., Collins A. δ-Aminolevulinic acid synthetase. I. Studies in liver homogenates. J Biol Chem. 241:1966;2803-2809.
34. Ohkawa H., Ohishi N., Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:1979;351-358.
35. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1961;265-275.
36. Chomczynski P., Sacchi A. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
37. Falk J.E. Porphyrins and Metalloporphyrins. 1964;Elsevier Publishing Co, New York.
38. Scholl H., Iba M.M. Pharmacokinetics of and CYP1A induction by pyridine and acetone in the rat Interactions and effects of route of exposure . Xenobiotica. 27:1997;265-277.
39. Yang H.-Y.L., Namkung M.J., Juchau M.R. Cytochrome-P-450-dependent biotransformation of a series of phenoxazone ethers in the rat conceptus during early organogenesis Evidence for multiple P-450 isoenzymes . Mol Pharmacol. 34:1988;67-73.
40. Scholl H, Fung J, Thomas PE, Alam J and Iba MM, Interactive induction of CYP1A by pyridine and acetone: Dose-response relationships. Fundam Appl Toxicol 36 (Suppl): 87, 1997.
41. Okey A.B., Riddick D.S., Harper P.A. Molecular biology of the aromatic hydrocarbon (dioxin) receptor. Trends Pharmacol Sci. 15:1994;226-232.
42. Watkins P.B., Wrighton S.A., Schuetz E.G., Maurel P., Guzelian P.S. Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. J Biol Chem. 261:1986;6264-6271.
43. Kyse S.M., Tyrell R.M. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci USA. 86:1989;99-103.
44. Murray M., Sefton R.M., Martini R., Butler A.M. Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides. Toxicol Lett. 93:1997;195-203.
45. Kikuchi G., Yoshida T. Function and induction of the microsomal heme oxygenase. Mol Cell Biochem. 53/54:1993;163-183.
46. Albores A., Sinal C.J., Cherian M.G., Bend J.R. Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute arsenite administration. Can J Physiol Pharmacol. 73:1995;153-158.
47. Stanley L.A., Adams D.J., Lindsay R., Meehan R.R., Liao W., Wolf C.R. Potentiation and suppression of mouse liver cytochrome P-450 isozymes during acute-phase response induced by bacterial endotoxin. Eur J Biochem. 174:1988;31-36.
48. Okuno F., Arai M., Sujita K., Eto S., Ishii H. Alterations in hepatic δ-aminolevulinic acid synthetase and heme oxygenase activities after chronic ethanol consumption in rats. Alcohol. 8:1991;449-451.
49. Kapitulnik J., Gonzalez F.J. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol Pharmacol. 43:1993;722-725.
50. Rannug A., Rannug U., Rosenkranz H.S., Winqvist L., Westerholm R., Agurell E., Grafstrom A.K. Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances. J Biol Chem. 262:1987;15422-15427.
51. Sindhu R.K., Risz-Porszasz S., Hankinson O., Kikkawa Y. Induction of cytochrome P4501A1 by photooxidized tryptophan in Hepa 1c1c7 cells. Biochem Pharmacol. 52:1996;1883-1893.