Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and no bioavailability in rats

Journal of Bone and Mineral Research

Volumn 22, Issue 8, 2007, Pages 1280-1288

  Prisby, Rhonda D ^a   Ramsey, Michael W ^b   Behnke, Brad J ^a   Dominguez II, James M ^a   Donato, Anthony J ^c   Allen, Matthew R ^d   Delp, Michael D ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Artery; Marrow blood flow; Trabecular BV TV

Indexed keywords

CYCLOOXYGENASE 1; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ACETYLCHOLINE; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITROPRUSSIDE SODIUM; PROSTAGLANDIN SYNTHASE INHIBITOR;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE BLOOD FLOW; CONTROLLED STUDY; DIAPHYSIS; FEMORAL ARTERY FLOW; METAPHYSIS; NONHUMAN; OSTEOLYSIS; PERFUSION; RAT; SIGNAL TRANSDUCTION; TRABECULAR BONE; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL; DRUG EFFECT; ENDOTHELIUM; FEMUR; FISCHER 344 RAT; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; VASCULARIZATION;

ACETYLCHOLINE; AGING; ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ENDOTHELIUM; FEMUR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; RATS; RATS, INBRED F344; RNA, MESSENGER; VASODILATION;

EID: 34548079262     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070415     Document Type: Article

References (50)

1. Lahtinen T, Alhava EM, Karjalainen P, Romppanen T 1981 The effect of age on blood flow in the proximal femur in man. J Nucl Med 22:966-972.
2. Bloomfield S, Hogan HA, Delp MD 2002 Decreases in bone blood flow and bone material properties in aging Fischer-344 rats. Clin Orthop 396:248-257.
3. Kita K, Kawai K, Hirohata K 1987 Changes in bone marrow blood flow with aging. J Orthop Res 5:569-575.
4. Burkhardt R, Kettner G, Bohm W, Schmidmeier M, Schlag R, Frisch B, Mallmann B, Eisenmenger W, Gilg T 1987 Changes in trabecular bone, hematopoiesis and bone-marrow vessels in aplastic-anemia, primary osteoporosis, and old-age: A comparative histomorphometric study. Bone 8:157-164.
5. Brookes M 1966 The vascular factor in osteoarthritis. Surg Gynecol Obstet 123:1255-1260.
6. Hughes S, Davies R, Khan R, Kelley P 1978 Fluid space in bone. Clin Orthop 134:332-341.
7. Jaffe H 1930 The resorption of bone. Arch Surg 20:355-385.
8. Trueta J 1953 The influence of the blood supply in controlling bone growth. Bull Hosp Joint Dis 14:147-157.
9. Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD 2000 Alterations in skeletal perfusion with simulated microgravity: A possible mechanism for bone remodeling. J Appl Physiol 89:1046-1054.
10. Collin-Osdoby P 1994 Role of vascular endothelial cells in bone biology. J Cell Biochem 55:304-309.
11. Hauge EM, Qvesel D, Eriksen EF, Mosekilde L, Melsen F 2001 Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res. 16:1575-1582.
12. Eriksen EF, Eghbali-Fatourechi GZ, Khosla S 2007 Remodeling and vascular spaces in bone. J Bone Miner Res 22:1-6.
13. Griffith JF, Yeung DKW, Antonia GE, Lee FKH, Hong AWL, Wong SYS, Lau EMC, Leung PC 2005 Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and MR Spectroscopy. Radiology 236:945-951.
14. Judex S, Gross TS, Bray RC, Zernicke RF 1997 Adaptation of bone to physiological stimuli. J Biomech 30:421-429.
15. Lüscher TF, Vanhoutte PM 1991 The Endothelium: Modulator of Cardiovascular Function. CRC Press, Boca Raton, FL, USA.
16. Nerem RM, Harrison DG, Taylor WR, Alexander RW 1993 Hemodynamics and vascular endothelial biology. J Cardiovasc Pharmacol 21(Suppl 1):S6-S10.
17. Ralston SH 1997 The Michael Mason Prize Essay. Nitric oxide and bone: What a gas! Br J Rheumatol 36:831-838.
18. Brookes M, Revell WJ 1998 Blood Supply of Bone: Scientific Aspects. Springer-Verlag, New York, NY, USA.
19. Kelly P 1983 Pathways of transport in bone. In: Sheppard JT, Abboud FM (eds.) The Handbook of Physiology: The Cardiovascular System III. Williams & Wilkins, Baltimore, MD, USA, pp. 371-396.
20. Delp MD, Manning RO, Bruckner JV, Armstrong RB 1991 Distribution of cardiac output during diurnal changes of activity in rats. Am J Physiol Heart Circ Physiol 261:H1487-H1493.
21. Muller-Delp JM, Spier SA, Ramsey MW, Delp MD 2002 Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles. Am J Physiol Heart Circ Physiol 283:H1662-H1672.
22. Muller-Delp JM, Spier SA, Ramsey MW, Lesniewsky LA, Papadopoulos A, Humphrey JD, Delp MD 2002 Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles. Am J Physiol Heart Circ Physiol 282:H1843-H1854.
23. Delp M 1999 Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading. J Appl Physiol 86:1178-1184.
24. Spier SA, Delp MD, Meininger CJ, Donato AJ, Ramsey MW, Muller-Delp JM 2004 Effects of ageing and exercise training on endothelium-dependent vasodilation and structure of rat skeletal muscle arterioles. J Physiol 556.3:947-958.
25. MacPherson JN, Tothill P 1978 Bone blood flow and age in the rat. Clin Sci Mol Med 54:111-113.
26. Brookes M 1960 Sequelae of experimental partial ischaemia in long bones of the rabbit. J Anat 94:552-561.
27. Jee W 2001 Integrated bone tissue physiology: Anatomy and physiology. In: Cowin S (ed.) Bone Mechanics Handbook. CRC Press, Boca Raton, FL, USA, pp. 1-1-1-34.
28. Jee W 1989 The skeletal tissues. In: Weiss L (ed.) Cell and Tissue Biology: A Textbook of Histology. Urban and Schwarzenberg, Baltimore, MD, USA, pp. 211-259.
29. Van Dyke D 1967 Similarity in distribution of skeletal blood flow and erythropoietic marrow. Clin Orthop 52:37-51.
30. Gross PM, Heistad DD, Marcus ML 1979 Neurohumoral regulation of blood flow to bones and marrow. Am J Physiol Heart Circ Physiol 237:H440-H448.
31. Delp MD, Brown M, Laughlin MH, Hasser EM 1995 Rat aortic vasoreactivity is altered by old age and hindlimb unloading. J Appl Physiol 78:2079-2086.
32. Dohi Y, Lüscher RF 1990 Aging differentially affects direct and indirect actions of endothelin 1 in rat mesenteric resistance arteries. Br J Pharmacol 100:889-893.
33. Moritoki H, Hosoki E, Ishida Y 1986 Age-related decrease in endothelium-dependent dilator response to histamine in rat mesenteric artery. Eur J Pharmacol 126:61-67.
34. Woodman CR, Price EM, Laughlin MH 2002 Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries. J Appl Physiol 93:1685-1690.
35. Turner C, Forwood MR, Otter MW 1994 Mechanotransduction in bone: Do bone cells act as sensors of fluid flow? FASEB J 8:875-878.
36. Parfitt A 2000 The mechanism of coupling: A role for the vasculature. Bone 26:319-323.
37. Reich K, Frangos JA 1991 Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts. Am J Physiol 261:C428-C432.
38. Riancho J, Salas E, Zarrabeitia MT, Olmos JM, Amado JA, Fernandez-Luna JL, Gonzalez-Macias J 1995 Expression and functional role of nitric oxide synthase in osteoblast-like cells. J Bone Miner Res 10:439-446.
39. Hikiji H, Shin WS, Oida S, Takato T, Koizumi T, Toyo-Oka T 1997 Direct action of nitric oxide on osteoblastic differentiation. FEBS Lett 410:238-242.
40. Johnson D, McAllister TN, Frangos JA 1996 Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol 271:E205-E208.
41. Smalt R, Mitchell FT, Howard RL, Chambers TJ 1997 Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain. Am J Physiol 273:E751-E758.
42. Banu J, Wang L, Kalu DN 2002 Age-related changes in bone mineral content and density in intact male F344 rats. Bone 30:125-130.
43. Brandes RP, Fleming I, Busse R 2005 Endothelial aging. Cardiovasc Res 66:286-294.
44. Lüscher TF, Barton M 1997 Biology of the endothelium. Clin Cardiol 20(Suppl 2):3-10.
45. Chambers T, Ali NN 1983 Inhibition of osteoclastic motility by prostaglandins I2, E1, E2 and 6- oxo-El. J Pathol 139:383-397.
46. Kasten T, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, Settle SL, Currie MG, Nickols GA 1994 Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 91:3569-3573.
47. Lowik C, Nibbering PH, van de Ruit M, Papapoulos SE 1994 Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 93:1465-1472.
48. MacIntyre I, Zaidi M, Alam AS, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR 1991 Osteoclastic inhibition: An action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88:2936-2940.
49. Rawlinson SC, el Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE 1991 Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling? J Bone Miner Res 6:1345-1351.
50. van't Hof R, Ralston SH 1997 Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity. J Bone Miner Res 12:1797-1804.