Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries

Journal of Applied Physiology

Volumn 93, Issue 5, 2002, Pages 1685-1690

  Woodman, Christopher R ^a   Price, Elmer M ^a   Laughlin, M Harold ^a  

^a NONE

Author keywords

Acetylcholine; Endothelial nitric oxide synthase; Nitric oxide; Sodium nitroprusside; Superoxide dismutase

Indexed keywords

ACETYLCHOLINE; ADENOSINE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SUPEROXIDE DISMUTASE;

AGED; AGING; ANIMAL TISSUE; ARTERY CATHETERIZATION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; FREEZING; HINDLIMB; MALE; MICROPIPETTE; MUSCLE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE;

EID: 0036873390     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00461.2002     Document Type: Article

References (28)

1. Aaker A and Laughlin MH. Differential adenosine sensitivity of diaphragm and skeletal muscle arterioles. J Appl Physiol 93: 848-856, 2002.
2. Awolesi MA, Sessa WC, and Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest 96: 1449-1454, 1995.
3. Barton M, Cosentino F, Brandes RP, Moreau P, Shaw S, and Luscher TF. Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin. Hypertension 30: 817-844, 1997.
4. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgapoulos D, Robinson J, and Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24: 471-476, 1994.
5. Cernadas MR, Sanchez de Miguel L, Garcia-Duran M, Gonzalez-Fernandez F, Millas I, Monton M, Guerra J, Carmelo C, Casado S, and Lopez-Farre A. Expression of constitutive and inducible nitric oxide synthases in vascular wall of young and aging rats. Circ Res 83: 279-286, 1998.
6. Challah M, Nadaud S, Philippe M, Battle T, Soubrier F, Corman B, and Mitchell JB. Circulating and cellular markers of endothelial dysfunction with aging in rats. Am J Physiol Heart Circ Physiol 273: H1941-H1948, 1997.
7. Chauhan A, More RS, Mullins PA, Taylor G, Petch MC, and Schofield PM. Aging associated endothelial dysfunction in humans is reversed by L-arginine. J Am Coll Cardiol 28: 1796-1804, 1996.
8. Corretti MC, Plotnick GD, and Vogel RA. The effects of age and gender on brachial artery endothelium dependent vasoactivity are stimulus dependent. Clin Cardiol 18: 471-476, 1995.
9. Delp MD, Evans MV, and Duan C. Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats. J Appl Physiol 85: 1813-1822, 1998.
10. Gerhard M, Roddy MA, Creager SJ, and Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27: 849-853, 1996.
11. Husken BCP, Hendricks MGC, Pfaffendorf M, and Van Zwieten PA. Effects of aging and hypertension on the reactivity of isolated conduit and resistance vessels. Microvasc Res 48: 303-315, 1994.
12. Inoue N, Ramasamy S, Fukai T, Nerem RM, and Harrison DG. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res 79: 32-37, 1996.
13. Irion GL, Vasthare US, and Tuma RF. Age-related change in skeletal muscle blood flow in the rat. J Gerontol 42: 660-665, 1987.
14. Jasperse JL and Laughlin MH. Vasomotor responses of soleus feed arteries from sedentary and exercise-trained rats. J Appl Physiol 86: 441-449, 1999.
15. Jasperse JL, Woodman CR, Price EM, Hasser EM, and Laughlin MH. Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 87: 1476-1482, 1999.
16. Kung CF and Luscher TF. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 25: 194-200, 1995.
17. Laughlin MH and Armstrong RB. Muscular blood flow distribution patterns as a function of running speeds in rats. Am J Physiol Heart Circ Physiol 243: H296-H306, 1982.
18. McDonald KS, Delp MD, and Fitts RH. Effect of hindlimb unweighting on tissue blood flow in the rat. J Appl Physiol 2210-2218, 1992.
19. Nadaud S, Philippe M, Arnal J, Michel J, and Soubrier F. Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow. Circ Res 79: 857-863, 1996.
20. Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, and Murphy TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 90: 2092-2096, 1992.
21. Norris M, Morigi M, Donadelli R, Aiello S, Foppolo M, Todeschini M, Orisio S, Remuzzi G, and Remuzzi A. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 76: 536-543, 1995.
22. Ranjan V, Xiao Z, and Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol Heart Circ Physiol 269: H550-H555, 1995.
23. Taddei S, Viridis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, and Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91: 1981-1987, 1995.
24. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, and Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol Cell Physiol 269: C1371-C1378, 1995.
25. Williams DA and Segal SS. Feed artery role in blood flow to rat hindlimb skeletal muscles. J Physiol 463: 631-646, 1993.
26. Woodman CR, Muller JM, Laughlin MH, and Price EM. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol Heart Circ Physiol 273: H2575-H2579, 1997.
27. Woodman CR, Muller JM, Rush JWE, Laughlin MH, and Price EM. Flow regulation of ecNOS and Cu/Zn SOD mRNA expression in porcine coronary arterioles. Am J Physiol Heart Circ Physiol 276: H1058-H1063, 1999.
28. Woodman CR, Schrage WS, Rush JWE, Ray CA, Price EM, Hasser EM, and Laughlin MH. Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius. J Appl Physiol 91: 1091-1098, 2001.