Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 283, Issue 4 52-4, 2002, Pages

  Muller Delp, Judy M ^a   Spier, Scott A ^a   Ramsey, Michael W ^a   Delp, Michael D ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Acetylcholine; Adenosine; Gastrocnemius; Indomethacin; NG nitro L arginine methyl ester; Nitric oxide; Soleus

Indexed keywords

ACETYLCHOLINE; ADENOSINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOLE; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; GASTROCNEMIUS MUSCLE; HINDLIMB; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; SKELETAL MUSCLE; SMOOTH MUSCLE; SOLEUS MUSCLE;

EID: 0036784007     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00004.2002     Document Type: Article

References (49)

1. Distribution of blood flow in muscles of miniature swine during exercise
2. Metabolic indicators of fibre recruitment in mammalian muscles during locomotion
3. Age-related alterations in the arterial microvasculature of skeletal muscle
4. Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter
5. Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading
6. Blood flow in normal and denervated muscle during exercise in conscious rats
7. Rat aortic vasoreactivity is altered by old age and hindlimb unloading
8. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity
9. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle
10. Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats
11. Time course of enhanced endothelium-mediated dilation in aorta of trained rats
12. Distribution of cardiac output during diurnal changes of activity in rats
13. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta
14. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
15. Cardiovascular responses to aging: A review
16. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans
17. Agerelated declines in maximal aerobic capacity in regularly exercising vs. sedentary women: A meta-analysis
18. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans
19. Effect of age on cardiovascular responses to static muscular contraction in beagles
20. Reduced exercise capacity in senescent beagles: An evaluation of the periphery
21. 2A receptors mediate coronary microvascular dilation to adenosine: Role of nitric oxide and ATP-sensitive potassium channels
22. Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats
23. Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery
24. Age-related change in skeletal muscle blood flow in the rat
25. Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries
26. Leg blood flow during exercise in man
27. Ageing suppresses endothelium-dependent relaxation and generates contraction mediated by the muscarinic receptors in vascular smooth muscle of normotensive Wistar-Kyoto and spontaneously hypertensive rats
28. Endothelium-dependent, flow-induced dilation of isolated coronary arterioles
29. Cardiovascular aging research: The next horizons
30. Remodeling of developing and mature arteries: Endothelium, smooth muscle, and matrix
31. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent
32. Adenosine analogues stimulate cyclic AMP formation in rabbit cerebral microvessels via adenosine A2-receptors
33. Distribution of adenosine A1, A2A and A2B receptors in human skeletal muscle
34. Effects of aging on responses of cerebral arterioles
35. Effects of fiber composition and hindlimb unloading on the vasodilator properties of skeletal muscle arterioles
36. Effect of hindlimb unweighting on tissue blood flow in the rat
37. Vasodilator responses of coronary resistance arteries of exercise-trained pigs
38. Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles
39. Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow
40. Effects of aging, sex, and physical training on cardiovascular responses to exercise
41. Reduced leg blood flow during dynamic exercise in older endurance-trained men
42. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression
43. Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats
44. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes
45. Aging and endothelial function in normotensive subjects and patients with essential hypertension
46. Hypertension and ageing impair acetylcholine-induced vasodilation in rats
47. Influence of age on the local circulatory adaptation to leg exercise
48. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs
49. Hindlimb unweighting decreases endothelium-dependent dilation and eNOS expression in soleus not gastrocnemius