Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation

Journal of Pharmaceutical Sciences

Volumn 96, Issue 8, 2007, Pages 2048-2056

  Gong, K ^a   Braden, M ^a   Patel, M P ^a   Rehman, I U ^a   Zhang, Z ^a   Darr, J A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Amorphous; Chlorhexidine diacetate; Controlled release; PEM THFM; Supercritical fluid

Indexed keywords

CHLORHEXIDINE ACETATE; METHACRYLIC ACID; POLY(ETHYL METHACRYLATE); TETRAHYDROFURFURYLMETHACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED RELEASE FORMULATION; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; FOAMING; RAMAN SPECTROMETRY; SUPERCRITICAL FLUID; X RAY DIFFRACTION;

EID: 34548079208     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20850     Document Type: Article

References (39)

1. Samaranayake LP, Nair RG. 1995. Oral candida infections a review. Ind J Dent Res 8:69-82.
2. Yamagish K, Onuma K, Suzuki T, Okada F, Tagami J, Otsuki M, Senawangse P. 2005. Materials chemistry: A synthetic enamel for rapid tooth repair. Nature 433:819-826.
3. Guney O, Akgerman A. 2002. Synthesis of controlled-release products in supercritical medium. Am Inst Chem Eng J 48:856-866.
4. Chiou WL, Riegelman S. 1971. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60:1281-1302.
5. Bhusate M, Braden M. 1985. Low shrinkage monomer polymer curable compositions useful in biomedical applications. UK Patent 2, 107:341B.
6. Patel MP, Braden M, Davy K. 1987. Polymerization shrinkage of methacrylate esters. Biomaterials 8:53-56.
7. Patel MP, Braden M. 1989. Crosslinking and ring opening during polymerization of heterocyclic methacrylates and acrylates. Biomaterials 10:277-280.
8. Patel MP, Braden M. 1991. Heterocyclic methacrylates for clinical applications I: Mechanical properties. Biomaterials 11:361-366.
9. Patel MP, Braden M. 1991. Heterocyclic methacrylates for clinical applications II: Room temperature polymerizing systems for potential clinical use. Biomaterials 12:645-648.
10. Patel MP, Braden M. 1991. Heterocyclic methacrylates for clinical applications III: Water absorption characteristics. Biomaterials 12:649-652.
11. Patel MP, Davy K, Braden M. 1992. Refractive index and molar refraction of methacrylate monomers and polymers. Biomaterials 13:643-645.
12. Braden M, Downes S, Patel MP, Davy K. 1991. The use of biomaterials for tissue repair. A polymeric system for the intra-oral delivery of an anti-fungal agent, UK Patent 91244871.
13. Downes S, Archer RS, Kayser MV, Patel MP, Braden M. 1994. The regeneration of articular cartilage using a new polymer system. J Mater Sci Mater Med 5:88-95.
14. Downes S, Braden M, Archer RS, Patel M, Davy K, Swai H. 1994. Modification of polymers for controlled hydrophilicity: the effect of surface properties In: West R, Batts G, Editors. Surface properties of biomaterials. Butterworth Heinemann. 11-23.
15. Patel MP, Braden M, Downes S. 1993. Heterocyclic methacrylate-based drug release polymer system. J Mater Sci, Mater Med 5:338-339.
16. Downes S, Patel M, Di-Silvio L, Swai H, Davy K, Braden M. 1995. Modification of the hydrophilicity of heterocyclic methacrylate copolymers for protein release biomaterials. Biomaterials 16:1417-1421.
17. Patel MP, Braden M, Pearson GJ. 1995. Fluoride releasing biomaterial, British patent application no 95011839.
18. Parker S, Patel MP, Tibaldi J, Braden M. 1997. Two methacrylate-based materials for intra-oral drug delivery. Plas Rubber Comp Proc Appl 26:298-302.
19. Riggs PD, Braden M, Patel MP. 2000. Chlorhexidine release from room temperature polymerization methacrylate systems. Biomaterials 21:345-351.
20. Patel MP, Cruchley AT, Coleman DC, Swai H, Braden M, Williams DM. 2001. A polymeric system for intra-oral delivery of an anti-fungal agent. Biomaterials 22:2319-2324.
21. Patel MP, Pavlovic P, Hughes FJ, King WN, Cruchly A, Braden M. 2001. Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems. Biomaterials 22:2081-2086.
22. Yeo SD, Kiran E. 2005. Formation of polymer particles with supercritical fluids: A review. J Supercrit Fluids 34:287-308.
23. Kim JH, Paxton TE, Tomasko DL. 1996. Microencapsulation of naproxen using rapid expansion of supercritical solutions. Biotech Prog 12:650-661.
24. Frederiksen L, Anton K, Hoogevest PV, Keller HR, Leuenberger H. 1997. Preparation of liposomes encapsulating water-soluble compounds using supercritical carbon dioxide. J Pharm Sci 86:921-928.
25. Charoenchaitrakool M, Dehghani F, Foster NR, Chan HK. 2000. Micronisation by RESS to enhance the dissolution rates of poorly water-soluble pharmaceuticals. Ind Eng Chem Res 39:4794-4802.
26. Corrigan AM. 2000. Comparative physicochemical properties of hydrocortisone-PVP composites prepared using supercritical carbon dioxide by the GAS Anti-solvent recrystallization process, by coprecipitation and by Spray Drying. Int J Pharm 245:75-82.
27. Kompella UB, Koushik K. 2001. Preparation of drug delivery systems using supercritical fluid technology. Crit Rev Therapeut Drug Car Sys 18:173-199.
28. Tom JW, Debenedetti PG. 1991. Particle formation with supercritical fluids - A Review. J Aerosol Sci 22:555.
29. Subramaniam B, Rajewski RA, Snavely K. 1997. Pharmaceutical processing with supercritical carbon dioxide. J Pharm Sci 86:885.
30. Marr R, Gamse T. 2000. Use of supercritical fluids for different processes including new development - A review. Chem Eng Proc 39:19.
31. Barry JJA, Gidda HS, Scotchfor CA, Howdle SM. 2004. Porous methacrylate scaffolds: Supercritical fluid fabrication and in vitro chondrocyte responses. Biomaterials 25:3559-3568.
32. Gong K, Viboonkiat R, Rehman IU, Buckton G, Darr JA. 2005. Formation and characterization of porous indomethacin-PVP coprecipitates prepared using solvent-free supercritical fluid processing. J Pharm Sci 94:2583-2590.
33. Gong K, Rehman IU, Darr JA. 2006. Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications. Int J Pharm 315:93-98.
34. Mi FL, Sung HW, Shyu SS. 2001. Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: Examination of crosslinking and polycation-anionic drug interaction. J Appl Poly Sci 81:1700-1711.
35. Perkampus HH. 1992. In UV-Vis. spectroscopy and its applications. Berlin, London: Springer-Verlag.
36. Kazarian SG, Martirosyan GG. 2002. Spectroscopy of polymer/drug formulations processed with supercritical fluids: In situ ATR-IR and Raman study of impregnation of ibuprofen into PVP. Int J Pharm 232:81-90.
37. Spiepmann J, Peppas NA. 2001. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Del Rev 48:139-157.
38. Ebube NK, Hibal A, Wyandt CM, Beer DC, Miller LG, Jones AB. 1997. Sustained release of acetaminophen from heterogeneous matrix tablets: Influence of polymer ratio, polymer loading, and co-active on drug release. Pharm Dev Tech 2:161-170.
39. Grolimund D, Barmettler K, Borkovec M. 2001. Release and transport of colloidal particles in natural porous media. Water Resources Res 37:571-582.