Biventricular hypertrophy in dogs with chronic AV block: Effects of cyclosporin A on morphology and electrophysiology

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  Schreiner, Kirsten D ^a   Kelemen, Kamilla ^a   Zehelein, Joerg ^a   Becker, Ruediger ^a   Senges, Julia C ^a   Bauer, Alexander ^a   Voss, Frederik ^a   Kraft, Patrizia ^a   Katus, Hugo A ^a   Schoels, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Mapping; Regression of hypertrophy; Torsade de pointes

Indexed keywords

ALMOKALANT; CYCLOSPORIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; BODY WEIGHT; CONTROLLED STUDY; DOG; DRUG EFFECT; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE TACHYCARDIA; HEART WEIGHT; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; REFRACTORY PERIOD; TORSADE DES POINTES;

ANIMALS; CARDIOMEGALY; CYCLOSPORINE; DOGS; ELECTROCARDIOGRAPHY; ENZYME INHIBITORS; HEART BLOCK; TORSADES DE POINTES; VENTRICULAR PREMATURE COMPLEXES;

EID: 9344261464     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01051.2003     Document Type: Article

References (25)

1. Allessie MA, Lammers WJEP, Bonke IM, and Hollen J. Intra-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog. Circulation 70: 123-135, 1984.
2. Batuik TD and Halloran PF. The downstream consequences of calcineurin inhibition. Transplant Proc 29: 1239-1240, 1997.
3. Ding B, Price R, Borg T, Weinberg EO, Halloran PF, and Lorell BH. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. Circ Res 84: 729-734, 1999.
4. Hill JA, Karimi M, Kutschke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, and Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation 101: 2863-2869, 2000.
5. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, and Lazzara R. The long-QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 31: 115-172, 1988.
6. Kozhevnikov DO, Yamamoto K, Robotis D, Restivo M, and El-Sherif N. Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns. Circulation 105: 1128-1134, 2002.
7. Lim HW, de Windt LJ, Steinberg L, Taigen T, Witt SA, Kimball TR, and Molkentin JD. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation 101: 2431-2437, 2000.
8. Luo Z, Shyu KG, Gualberto A, and Walsh K. Calcineurin inhibitors and cardiac hypertrophy. Nat Med 4: 1092-1093, 1998.
9. Meguro T, Hong C, Asai K, Takagi G, McKinsey TA, Olsen EN, and Vatner SF. Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ Res 84: 735-740, 1999.
10. Mende U, Kagen A, Cohen J, Aramburu J, Schoen FJ, and Neer EJ. Transient cardiac expression of constitutively activated Gα leads to cardiac hypertrophy and dilated cardiomyopathy by calcineurin-dependent and -independent pathways. Proc Natl Acad Sci USA 95: 1393-1398, 1998.
11. Molkentin JD, Lu JR, Antos C, Markham R, Richardson J, Robbins J, Grant SR, and Olsen EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228, 1998.
12. Müller JG, Nemoto S, Laser M, Carabello BA, and Menick DR. Calcineurin inhibition and cardiac hypertrophy (Abstract). Science 282: 1007, 1998.
13. Rials SJ, Wu Y, Ford N, Pauletto FJ, Abramson SV, Rubin AM, Marinchak RA, and Kowey PR. Effect of left ventricular hypertrophy and its regression on ventricular electrophysiology and vulnerability to inducible arrhythmia in the feline heart. Circulation 91: 426-430, 1995.
14. Rials SJ, Wu Y, Xu X, Filart RA, Marinchak RA, and Kowey PR. Regression of left ventricular hypertrophy with captopril restores normal ventricular action potential duration, dispersion of refractoriness, and vulnerability to inducible ventricular fibrillation. Circulation 96: 1330-1336, 1997.
15. Sakata Y, Masuyama T, Yamamoto K, Nishikawa N, Yamamoto H, Kondo H, Ono K, Otsu K, Kuzuya T, Miwa T, Takeda H, Takeda H, Miyamoto E, and Hori M. Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats. Circulation 102: 2269-2275, 2000.
16. Schoenmakers M, Ramakers C, van Opstal JM, Leunissen JDM, Londono C, and Vos MA. Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. Cardiovasc Res 59: 351-359, 2003.
17. Senges JC, Sterns LD, Schoels W, Freigang KD, Bauer A, Becker R, and Kubler W. Cesium chloride induced ventricular arrhythmias in dogs: three-dimensional activation patterns and their relation to the cesium dose applied. Basic Res Cardiol 95: 152-162, 2000.
18. Shimoyama M, Hayashi D, Zou Y, Takimoto E, Mizukami M, Monzen K, Kudoh S, Hori Y, Yazaki Y, Nagai R, and Komuro I. Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. Circulation 102: 1996-2004, 2000.
19. Sugden PH. Signaling in myocardial hypertrophy. Life after Calcineurin? Circ Res 84: 633-646, 1999.
20. Sussman MA, Lim HW, Gude N, Taigen T, Olsen EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, and Molkentin JD. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 281: 1690-1693, 1998.
21. Verduyn SC, Vos MA, van der Zande J, Kulcsar A, and Wellens HJ. Further observations to elucidate the role of interventricular dispersion of repolarization and early afterdepolarizations in the genesis of acquired torsade de pointes arrhythmias: a comparison between almokalant and d-sotalol using the dog as its own control. J Am Coll Cardiol 30: 1575-1584, 1997.
22. + currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 100: 2455-2461, 1999.
23. Vos MA, de Groot SHM, Verduyn SC, Lipscei GC, and Wellens HJ. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation 98: 1125-1135, 1998.
24. Vos MA, Verduyn SC, Gorgels APM, van der Zande J, Leunissen HD, Cleutjens JP, van Bilsen M, Daemen MJ, Schreuder JJ, Allessie MA, and Wellens HJ. Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 91: 864-872, 1995.
25. Zhang W, Kowal R, Rusnak F, Sikkink RA, Olsen EN, and Victor RG. Failure of Calcineurin inhibitors to prevent pressure-overloaded left ventricular hypertrophy in rats. Circ Res 84: 722-728, 1999.