Simultaneous measurement of water desorption isotherm and heats of water desorption of proteins using perfusion isothermal microcalorimetry

Journal of Pharmaceutical Sciences

Volumn 96, Issue 8, 2007, Pages 1974-1982

  Luthra, Sumit ^a,c   Lechuga Ballesteros, David ^b   Kalonia, Devendra S ^a   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NEKTAR THERAPEUTICS   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Desorption isotherm; Dynamic glass transition; Heats of desorption; Perfusion calorimetry; Proteins; Water

Indexed keywords

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN G; LYSOZYME; PARAPROTEIN; WATER;

ARTICLE; DESORPTION; ENTHALPY; EVAPORATION; HYDRATION; ISOTHERM; ISOTHERMAL TITRATION CALORIMETRY; MATHEMATICAL MODEL; MICROCALORIMETRY; PROTEIN INTERACTION; PROTEIN STABILITY; THERMODYNAMICS; WATER VAPOR;

EID: 34548024844     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20836     Document Type: Article

References (21)

1. Rupley JA, Careri G. 1991. Protein hydration and function. Adv Protein Chem 41:37-172.
2. Gregory RB. 1995. Protein hydration and glass transition behavior. In: Gregory RB, editor. Protein-solvent interactions, edition. New York: Marcel Dekker, Inc., pp 191-264.
3. Hill JJ, Shalaev EY, Zografi G. 2005. Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration. J Pharm Sci 94:1636-1667.
4. Pikal MJ. 2004. Mechanisms of protein stabilization during freeze-drying and storage: The relative importance of thermodynamic stabilization and glassy state relaxation dynamics. Drugs Pharm Sci 137 (Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products):63-107.
5. Hageman MJ. 1992. Water sorption and solid-state stability of proteins. Pharm Biotechnol 2 (Stability of Protein Pharmaceuticals, Pt. A):273-309.
6. D'Arcy RL, Watt IC. 1970. Analysis of sorption isotherms of nonhomogeneous sorbents. Trans Faraday Soc 66:1236-1245.
7. Markova N, Sparr E, Wadso L. 2001. On application of an isothermal sorption microcalorimeter. Thermochimica Acta 374:93-104.
8. Smith Allan L, Shirazi Hamid M, Mulligan SR. 2002. Water sorption isotherms and enthalpies of water sorption by lysozyme using the quartz crystal microbalance/heat conduction calorimeter. Biochimica et Biophysica Acta 1594:150-159.
9. Luscher-Mattli M. 1986. Thermodynamic parameters of biopolymer-water systems. In: Hinz H-J, editor. Thermodynamic data for biochemistry and biotechnology, edition. Berlin: Springer-Verlag, pp 276-294.
10. Bone S. 1996. Dielectric and gravimetric studies of water binding to lysozyme. Phys Med Biol 41:1265-1275.
11. Kocherbitov V, Arnebrant T, Soederman O. 2004. Lysozyme-water interactions studied by sorption calorimetry. J Phys Chem B 108:19036-19042.
12. Wadso L, Markova N. 2000. A double twin isothermal microcalorimeter. Thermochimica Acta 360:101-107.
13. Lehto V-P, Laine E. 2000. Simultaneous determination of the heat and the quantity of vapor sorption using a novel microcalorimetric method. Pharm Res 17:701-706.
14. Lehto VP, Laine E. 2001. Characterization of lactose powder surfaces by isothermal microcalorimetry. J Therm Anal Calorimetry 64:731-738.
15. Lechuga-Ballesteros D, Bakri A, Miller DP. 2003. Microcalorimetric measurement of the interactions between water vapor and amorphous pharmaceutical solids. Pharm Res 20:308-318.
16. Tang X, Pikal MJ. 2004. Design of freeze-drying processes for pharmaceuticals: Practical advice. Pharm Res 21:191-200.
17. Pikal MJ, Lang JE, Shah S. 1983. Desolvation kinetics of cefamandole sodium methanolate: The effect of water vapor. Int J Pharm 17:237-262.
18. Prestrelski SJ, Tedeschi N, Arakawa T, Carpenter JF. 1993. Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers. Biophys J 65:661-671.
19. Luthra S, Kalonia DS, Pikal MJ. 2007. Effect of Hydration on the Secondary Structure of Lyophilized Proteins as Measured by Fourier Transform Infrared (FTIR) Spectroscopy. J Pharm Sci (in press).
20. Gekko K, Kimoto A, Kamiyama T. 2003. Effects of disulfide bonds on compactness of protein molecules revealed by volume, compressibility, and expansibility changes during reduction. Biochemistry 42:13746-13753.
21. Luthra S, Obert J-P, Kalonia DS, Pikal MJ. 2007. Impact of critical process and formulation parameters affecting in-process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: A mini freeze dryer study. J Pharm Sci (in press).