Impact of critical process and formulation parameters affecting in-process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: A mini freeze dryer study

Journal of Pharmaceutical Sciences

Volumn 96, Issue 9, 2007, Pages 2242-2250

  Luthra, Sumit ^a,b   Obert, Jean Philippe ^a,c   Kalonia, Devendra S ^a   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c DANISCO INNOVATION   (France)

Author keywords

Formulation; Freeze drying; Lyophilization; Proteins; Stability

Indexed keywords

CITRIC ACID; HEAT SHOCK PROTEIN; LACTATE DEHYDROGENASE; POLYSORBATE 80; POVIDONE; SORBITOL; SUCROSE;

ARTICLE; DRUG STABILITY; FREEZE DRYING; HUMIDITY; HYDROGEN BOND; MOLECULAR DYNAMICS; PROTEIN INTERACTION; PROTEIN STABILITY; TEMPERATURE; VITRIFICATION; WATER CONTENT;

EID: 34548022401     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20889     Document Type: Article

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