Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 8, 2007, Pages 1145-1150

  Geng, Peng ^a   Yang, Yang ^a   Gao, Zhihui ^a   Yu, Yangsheng ^a   Shi, Qian ^a   Bai, Gang ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; ALPHA GLUCOSIDASE; CHOLESTEROL; FLAVONOID; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FECULAE BOMBYCIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; MOUSE; NONHUMAN; RAT; WORM;

ADMINISTRATION, ORAL; ALKALOIDS; ALPHA-GLUCOSIDASES; ANIMALS; BLOOD GLUCOSE; BOMBYX; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; FLAVONOIDS; INTESTINES; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; PLANT EXTRACTS; PLANTS, MEDICINAL; POSTPRANDIAL PERIOD; RATS; RATS, WISTAR; STARCH;

EID: 34547958065     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.8.0013     Document Type: Article

References (27)

1. Anjaneyulu, M., Chopra, K. (2004) Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin. Exp. Pharmacol. Physiol. 31: 244-248
2. Asano, N., Oseki, K., Tomioka, E., Kizu, H., Matsui, K. (1994a) N-Containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr. Res. 259: 243-255
3. Asano, N., Tomioka, E., Kizu, H., Matsui, K. (1994b) Sugar with nitrogen in the ring isolated from the leaves of Morus bombycis. Carbohydr. Res. 253: 235-245
4. Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H., Kameda, Y., Kato, A., Nash, R. J., Lee, H. S., Ryu, K. S. (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric. Food Chem. 49: 4208-4213
5. Asgary, S., Naderi, G., Sarrafzadegan, N., Ghassemi, N., Boshtam, M., Rafie, M., Arefian, A. (1999) Anti-oxidant effect of flavonoids on hemoglobin glycosylation. Pharm. Acta Helv. 73: 223-226
6. Coldiron, A. D., Sanders, R. A., Watkins, J. B. (2002) Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. J. Biochem. Mol. Toxicol. 16: 197-202
7. Coskun, O., Kanter, M., Korkmaz, A., Oter, S. (2005) Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol. Res. 51: 117-123
8. Degenhardt, A., Engelhardt, U. H., Lakenbrink, C., Winterhalter, P. (2000) Preparative separation of polyphenols from tea by high-speed countercurrent chromatography. J. Agric. Food Chem. 48: 3425-3430
9. Gao, H., Nishioka, T., Kawabata, J., Kasai, T. (2004) Structure-activity relationships for α-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. Biosci. Biotechnol. Biochem. 68: 369-375
10. Geng, P., Zhu, Y. Y., Yang, Y., Jiang, N., Bai, G., Yang, W. B. (2005) Analysis and bio-activity detection of the α-glucosidase inhibitors in total alkaloids from Feculae bombycis. Zhong Cao Yao (Chinese Traditional and Herbal Drugs) 36: 159-162 (in Chinese)
11. Hakamata, W., Nakanishi, I., Masuda, Y., Shimizu, T., Higuchi, H., Nakamura, Y., Saito, S., Urano, S., Oku, T., Ozawa, T., Ikota, N., Miyata, N., Okuda, H., Fukuhara, K. (2006) Planar catechin analogues with alkyl side chains: a potent antioxidant and an α-glucosidase inhibitor. J. Am. Chem. Soc. 128: 6524-6525
12. Havsteen, B. (1983) Flavonoid, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32: 1141-1148
13. Kawabata, J., Mizuhata, K., Sato, E., Nishioka, T., Aoyama, Y., Kasai, T. (2003) 6-Hydroxyflavoids as α-glucosidase inhibitors from Marjoram (Origanum majorana) leaves. Biosci. Biotechnol. Biochem. 67: 445-447
14. Kim, J. S., Kwon, C. S., Son, K. H. (2000) Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotechnol. Biochem. 64: 2458-2461
15. Kim, J. W., Kim, S. U., Lee, H. S., Kim, I., Ahn, M. Y., Ryu, K. S. (2003) Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography. J. Chromatogr. A 1002: 93-99
16. Kimura, M., Chen, F. (1995) Antihyperglycemic effects of N-containing sugars derived from mulberry leaves in streptozocin induced diabetic mice. Wakan Iyakugaku Zasshi 12: 214-219
17. Krishna, K. M., Annapurna, A., Gopal, G. S., Chalam, C. R., Madan, K., Kumar, V. K., Prakash, G. J. (2005) Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Can. J. Physiol. Pharmacol. 83: 343-355
18. Laar, F. A., Lucassen, P. L., Akkermans, R. P., Lisdonk, E. H., Rutten, G. E., Weel, C. (2005) Alpha-glucosidase inhibitors for patients with type 2 diabetes. Diabetes Care 28: 154-163
19. Lean, M. E., Noroozi, M., Kelly, I., Burns, J., Talwar, D., Sattar, N., Crozier, A. (1999) Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 48: 176-181
20. Mahesh, T., Menon, V. P. (2004) Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats. Phytother. Res. 18: 123-127
21. McDougall, G. J., Stewart, D. (2005) The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 23: 189-195
22. Miyahara, C., Miyazawa, M., Satoh, S., Sakai, A., Mizusaki, S. (2004) Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. J. Nutr. Sci. Vitaminol. 50: 161-164
23. Ramachandra, R., Shetty, A. K., Salimath, P. V. (2005) Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats. Mol. Nutr. Food Res. 49: 355-360
24. Sanders, R. A., Rauscher, F. M., Watkins, J. B. (2001) Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxicol. 15: 143-149
25. Tanaka, S., Han, L. K., Zheng, Y. N., Okuda, H. (2004) Effects of the flavonoid fraction from Ginkgo biloba extract on the postprandial blood glucose elevation in rats. Pharm. Soc. Japan 124: 605-611
26. Vessal, M., Hemmati, M., Vasei, M. (2003) Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 135C: 357-364
27. Vogel, H. G., Vogel, W. H. (2001) (eds) Drug discovery and evaluation: pharmacological assays. Sage, Beijing