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Use of the common (peptide) coupling reagents [DCC, TCT, Hf(IV) salts, HBTU, HATU, and PyBroP] failed to provide the allenoate product. Presumably, the product allenoate is susceptible to nucleophilic attack by either a base present in the reaction medium or the byproducts derived from the coupling reagents. See the Supporting Information for details regarding the isolation and characterization of the product of N-hydroxybenzotriazole addition to the allenoate when using HBTU.
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Use of the common (peptide) coupling reagents [DCC, TCT, Hf(IV) salts, HBTU, HATU, and PyBroP] failed to provide the allenoate product. Presumably, the product allenoate is susceptible to nucleophilic attack by either a base present in the reaction medium or the byproducts derived from the coupling reagents. See the Supporting Information for details regarding the isolation and characterization of the product of N-hydroxybenzotriazole addition to the allenoate when using HBTU.
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The connectivity and relative stereochemistry of this compound were assigned through NMR spectroscopic analyses. See the Supporting Information for details
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The connectivity and relative stereochemistry of this compound were assigned through NMR spectroscopic analyses. See the Supporting Information for details.
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NOE analyses confirmed the trans stereochemistry of the [3 + 2] annulation product. See the Supporting Information for details.
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NOE analyses confirmed the trans stereochemistry of the [3 + 2] annulation product. See the Supporting Information for details.
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