Trafficking and regulation of neuronal voltage-gated calcium channels

Current Opinion in Cell Biology

Volumn 19, Issue 4, 2007, Pages 474-482

  Jarvis, Scott E ^a   Zamponi, Gerald W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VOLTAGE GATED CALCIUM CHANNEL;

CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; HUMAN; MEMBRANE TRANSPORT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; REVIEW;

ANIMALS; CALCIUM CHANNELS; GTP-BINDING PROTEINS; HUMANS; NEURONS; PROTEIN TRANSPORT;

EID: 34547950499     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2007.04.020     Document Type: Review

References (51)

1. Catterall W.A., Perez-Reyes E., Snutch T.P., and Striessnig J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 57 4 (2005) 411-425
2. v1.2 encodes a transcription factor. Cell 127 3 (2006) 591-606. This study presents evidence that proteolytic cleavage of the Cav1.2 L-type calcium channel C-terminus translocates to the nucleus where its acts as a transcription factor.
3. 2+ channels: a functional patchwork. Trends Neurosci 26 12 (2003) 683-687
4. Khosravani H., and Zamponi G.W. Voltage-gated calcium channels and idiopathic generalized epilepsies. Physiol Rev 86 3 (2006) 941-966
5. Arikkath J., and Campbell K.P. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 13 3 (2003) 298-307
6. 2-δ subunits: differential expression, function, and drug binding. J Bioenerg Biomembr 35 6 (2003) 639-647
7. Kang M.G., and Campbell K.P. Gamma subunit of voltage-activated calcium channels. J Biol Chem 278 24 (2003) 21315-21318
8. Yasuda T., Chen L., Barr W., McRory J.E., Lewis R.J., Adams D.J., and Zamponi G.W. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur J Neurosci 20 1 (2004) 1-13
9. v2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow" and "closed-state" inactivation. J Gen Physiol 123 (2004) 401-416
10. Meir A., Bell D.C., Stephens G.J., Page K.M., and Dolphin A.C. Calcium channel β subunit promotes voltage-dependent modulation of α1B by Gβγ. Biophys J 79 (2000) 731-746
11. Altier C., Dubel S.J., Barrere C., Jarvis S.E., Stotz S.C., Spaetgens Rl., Scott J.D., Cornet V., De Waard M., Zamponi G.W., Nargeot J., and Bourinet E. Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem 277 37 (2002) 33598-33603
12. Tareilus E., Roux M., Qin N., Olcese R., Zhou J., Stefani E., and Birnbaumer L. A Xenopus oocyte β subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate. Proc Natl Acad Sci U S A 94 5 (1997) 1703-1708
13. Canti C., Davies A., Berrow N.W., Butcher A.J., Page K.M., and Dolphin A.C. Evidence for two concentration-dependent processes for β-subunit effects on α1B calcium channels. Biophys J 81 (2001) 1439-1451
14. 2+ channels. Proc Natl Acad Sci U S A 102 32 (2005) 11320-11325. The authors identify a key metal ion binding site on the calcium channel α2-δ subunit, which is crucial for the targeting of L-type calcium channels to the plasma membrane.
15. Leroy J., Richards M.W., Butcher A.J., Nieto-Rostro M., Pratt W.S., Davies A., and Dolphin A.C. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J Neurosci 25 30 (2005) 6984-6996
16. Cornet V., Bichet D., Sandoz G., Marty I., Brocard J., Bourinet E., Mori Y., Villaz M., and De Waard M. Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum. Eur J Neurosci 16 5 (2002) 883-895
17. Vβ can reconstitute both trafficking and macroscopic conductance of voltage-dependent calcium channels. J Physiol 567 Pt 3 (2005) 757-769
18. 1-β-subunit interaction that modulates calcium channel activity is reversible and requires a competent α-interaction domain. J Biol Chem 281 (2006) 24104-24110
19. Barclay J., Balaguero N., Mione M., Ackerman S.L., Letts V.A., Brodbeck J., Canti C., Meir A., Page K.M., Kusumi K., et al. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci 21 16 (2001) 6095-6104
20. Donato R., Page K.M., Koch D., Nieto-Rostro M., Foucault I., Davies A., Wilkinson T., Rees M., Edwards F.A., and Dolphin A.C. The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci 26 48 (2006) 12576-12586
21. Davies A., Douglas L., Hendrich J., Wrattan J., Tran Van Minh A., Foucault I., Koch D., Pratt W.S., Saibil H.R., and Dolphin A.C. The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. J Neurosci 26 34 (2006) 8748-8757
22. 2+ channel expressed in Xenopus oocytes. J Physiol 532 Pt 3 (2001) 583-593
23. Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., and Dolphin A.C. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. EMBO J 21 (2002) 1514-1523
24. v2 calcium channels. Pharmacol Rev 58 4 (2006) 837-862
25. Kelly K. The RGK family: a regulatory tail of small GTP-binding proteins. Trends Cell Biol 15 12 (2005) 640-643
26. Chen H., Puhl III H.L., Niu S.L., Mitchell D.C., and Ikeda S.R. Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density. J Neurosci 25 42 (2005) 9762-9772. This study presents analysis of neuron-specific Rem2's regulation of the N-type calcium channel in multiple cell systems. The authors demonstrate that Rem2 interacts with a pre-assembled N-type channel complex to form a nonconducting species. Evidence that Rem2 effects occur independent of GTP binding is presented.
27. Béguin P., Mahalakshmi R.N., Nagashima K., Cher D.H.K., Kuwamura N., Yamada Y., Seino Y., and Hunziker W. Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2. Biochem J 390 (2005) 67-75
28. 2+/calmodulin and calcium channel β subunits that govern surface expression of voltage-gated calcium channels.
29. 2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature 411 (2001) 701-706
30. Ward Y., Spinelli B., Quon M.J., Chen H., Ikeda S.R., and Kelly K. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. Mol Cell Biol 24 2 (2004) 651-661
31. 2+ channel β-subunit and the Rem GTPase. J Biol Chem 281 33 (2006) 23557-23566
32. 2+ channels - integration centers for neuronal signalling pathways. Trends Neurosci 29 11 (2006) 617-624
33. v2.2 channels by 14-3-3 proteins. Neuron 51 (2006) 755-771. The authors report a direct physical interaction of N-type calcium channels with 14-3-3 proteins. This interaction was shown to regulate calcium channel inactivation and consequently synaptic activity.
34. Finlin B.S., Crump S.M., Satin J., and Andres D.A. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Proc Natl Acad Sci U S A 100 24 (2003) 14469-14474
35. 2+ channels by RGK GTPases. J Gen Physiol 128 5 (2006) 605-613
36. Paradis S., Harrar D.B., Lin Y., Koon A.C., Hauser J.L., Griffith E.C., Zhu L., Brass L.F., Chen C., and Greenberg M.E. An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron 53 (2007) 217-232. The authors conduct siRNA knockdown screens to elucidate the roles of 22 different cadherin members in the formation of glutamatergic and GABAergic synapses. This included a knockdown of Rem2, which revealed a key role of this protein in synapse development.
37. 2+ channelopathy. Neuron 43 3 (2004) 387-400
38. Li Q., Lau A., Morris T.J., Guo L., Fordyce C.B., and Stanley E.F. A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization. J Neurosci 24 16 (2004) 4070-4081
39. Wittemann S., Mark M.D., Rettig J., and Herlitze S. Synaptic localization and presynaptic function of calcium channel beta 4-subunits in cultured hippocampal neurons. J Biol Chem 275 48 (2000) 37807-37814
40. Jarvis S.E., and Zamponi G.W. Masters or slaves? Vesicle release machinery and the regulation of presynaptic calcium channels. Cell Calcium 37 5 (2005) 483-488
41. Maximov A., and Bezprozvanny I. Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neurosci 22 16 (2002) 6939-6952. This study presents structural determinants underlying trafficking of N-type calcium channels to synapses or axons, and the roles of Mint1 and CASK.
42. Kulik A., Nakadate K., Hagiwara A., Fukazawa Y., Lujan R., Suzuki N., Futatsugi A., Mikoshiba K., Frotscher M., and Shigemoto R. Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum. Eur J Neurosci 19 8 (2004) 2169-2178
43. Mochida S., Westenbroek R.E., Yokoyama C.T., Zhong H., Myers S.J., Scheuer T., Itoh K., and Catterall W.A. Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels. Proc Natl Acad Sci U S A 100 5 (2003) 2819-2824
44. V2.2 in hippocampal neurons. Eur J Neurosci 24 3 (2006) 709-718
45. Kamp M.A., Krieger A., Henry M., Hescheler J., Weiergraber M., and Schneider T. Presynaptic 'Ca2.3-containing' E-type Ca channels share dual roles during neurotransmitter release. Eur J Neurosci 21 6 (2005) 1617-1625
46. Fache M.P., Moussif A., Fernandes F., Giraud P., Garrido J.J., and Dargent B. Endocytotic elimination and domain-selective tethering constitute a potential mechanism of protein segregation at the axonal initial segment. J Cell Biol 166 4 (2004) 571-578
47. Bernstein G.M., and Jones O.T. Kinetics of internalization and degradation of N-type voltage-gated calcium channels: role of the alpha(2)/delta subunit. Cell Calcium 41 1 (2007) 27-40
48. Beedle A.M., McRory J.E., Poirot O., Doering C.J., Altier C., Barrere C., Hamid J., Nargeot J., Bourinet E., and Zamponi G.W. Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nat Neurosci 7 2 (2004) 118-125
49. Altier C., Khosravani H., Evans R.M., Hameed S., Peloquin J.B., Vartian B.A., Chen L., Beedle A.M., Ferguson S.S., Mezghrani A., Dubel S.J., Bourinet E., McRory J.E., and Zamponi G.W. ORL1 receptor-mediated internalization of N-type calcium channel complexes. Nat Neurosci 9 (2006) 31-40. This paper shows that prolonged agonist activation of ORL1 receptors results in translocation of ORL1 receptor/N-type channel signaling complexes into lysosomes for degradation, thus constituting a novel means of N-type channel regulation.
50. Tombler E., Cabanilla N.J., Carman P., Permaul N., Hall J.J., Richman R.W., Lee J., Rodriguez J., Felsenfeld D.P., Hennigan R.F., and Diversé-Pierluissi M.A. G protein-induced trafficking of voltage-dependent calcium channels. J Biol Chem 281 3 (2006) 1827-1839
51. Puckerin A., Liu L., Permaul N., Carman P., Lee J., and Diversé-Pierluissi M.A. Arrestin is required for agonist-induced trafficking of voltage-dependent calcium channels. J Biol Chem 281 41 (2006) 31131-31141