Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2

Biochemical Journal

Volumn 390, Issue 1, 2005, Pages 67-75

  Béguin, Pascal ^a   Mahalakshmi, Ramasubbu Narayanan ^a   Nagashima, Kazuaki ^b   Cher, Damian Hwee Kiat ^a   Kuwamura, Naomitsu ^b   Yamada, Yuichiro ^b   Seino, Yutaka ^b   Hunziker, Walter ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

14 3 3; Calcium channel; Calmodulin (CaM); kir Gem; Rad; Rem2

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; PROTEINS;

CALMODULIN BINDING; CELL-SHAPE REMODELLING; RGK PROTEINS;

CELLS;

CALMODULIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN 14 3 3; PROTEIN REM2; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CELL NUCLEUS; CELL STRAIN COS1; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; SEQUENCE ANALYSIS;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CALCIUM CHANNELS; CALMODULIN; CELL LINE; CELL SHAPE; GENE EXPRESSION REGULATION; HUMANS; ION TRANSPORT; MONOMERIC GTP-BINDING PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN SUBUNITS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 23944467523     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050414     Document Type: Article

References (31)

1. Maguire, J., Santoro, T., Jensen, P., Siebenlist, U., Yewdell, J. and Kelly, K. (1994) Gem: an induced, immediate early protein belonging to the Ras family. Science 265, 241-244
2. Cohen, L., Mohr, R., Chen, Y. Y., Huang, M., Kato, R., Dorin, D., Tamanoi, F., Goga, A., Afar, D. and Rosenberg, N. et al (1994) Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proc. Natl. Acad. Sci. U.S.A. 91, 12448-12452
3. Reynet, C. and Kahn, C. R. (1993) Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science 262, 1441-1444
4. Finlin, B. S. and Andres, D. A. (1997) Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation. J. Biol. Chem. 272, 21982-21988
5. Finlin, B. S., Shao, H., Kadono-Okuda, K., Guo, N. and Andres, D. A. (2000) Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem. J. 347, 223-231
6. Dolphin, A. C. (1998) Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J. Physiol. 506, 3-11
7. 2+ channels. Annu. Rev. Cell Dev. Biol. 16, 521-555
8. Dolphin, A. C. (2003) Beta subunits of voltage-gated calcium channels. J. Bioenerg. Biomembr. 35, 599-620
9. 2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature (London) 411, 701-706
10. Finlin, B. S., Crump, S. M., Satin, J. and Andres, D. A. (2003) Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Proc. Natl. Acad. Sci. U.S.A. 100, 14469-14474
11. 2+ channel activity and insulin secretion by the Rem2 GTPase. J. Biol. Chem., doi.10.1074/jbc.M414261200
12. Pan, J. Y., Fieles, W. E., White, A. M., Egerton, M. M. and Silberstein, D. S. (2000) Ges, a human GTPase of the Rad/Gem/Kir family, promotes endothelial cell sprouting and cytoskeleton reorganization. J. Cell Biol. 149, 1107-1116
13. Leone, A., Mitsiades, N., Ward, Y., Spinelli, B., Poulaki, V., Tsokos, M. and Kelly, K. (2001) The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma. Oncogene 20, 3217-3225
14. Ward, Y., Yap, S. F., Ravichandran, V., Matsumura, F., Ito, M., Spinelli, B. and Kelly, K. (2002) The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. J. Cell Biol. 157, 291-302
15. Fischer, R., Wei, Y., Anagli, J. and Berchtold, M. W. (1996) Calmodulin binds to and inhibits GTP binding of the ras-like GTPase Kir/Gem. J. Biol. Chem. 271, 25067-25070
16. Moyers, J. S., Bilan, P. J., Zhu, J. and Kahn, C. R. (1997) Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. J. Biol. Chem. 272, 11832-11839
17. Mackintosh, C. (2004) Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem. J. 381, 329-342
18. Rubio, M. P., Geraghty, K. M., Wong, B. H., Wood, N. T., Campbell, D. G., Morrice, N. and Mackintosh, C. (2004) 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. Biochem. J. 379, 395-408
19. Yaffe, M. B. (2002) How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett. 513, 53-57
20. Ward, Y., Spinelli, B., Quon, M. J., Chen, H., Ikeda, S. R. and Kelly, K. (2004) Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. Mol. Cell. Biol. 24, 651-661
21. Finlin, B. S. and Andres, D. A. (1999) Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. Arch. Biochem. Biophys. 368, 401-412
22. Finlin, B. S., Shao, H., Kadono-Okuda, K., Quo, N. and Andres, D. A. (2000) Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem. J. 347, 223-231
23. Altier, C., Dubel, S. J., Barrere, C., Jarvis, S. E., Stotz, S. C., Spaetgens, R. L., Scott, J. D., Cornet, V., De Waard, M., Zamponi, G. W. et al. (2002) Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J. Biol. Chem. 277, 33598-33603
24. Beguin, P., Mahalakshmi, R. N., Nagashima, K., Cher, D. H. K., Takahashi, A., Yamada, Y., Seino, Y. and Hunziker, W. (2005) 14-3-3 and calmodulin control subcellular distribution of kir/Gem and its regulation of cell shape and calcium channel activity. J. Cell Sci. 118, 1923-1934
25. Lilla, V., Webb, G., Rickenbach, K., Maturana, A., Steiner, D. F., Halban, P. A. and Irminger, J. C. (2003) Differential gene expression in well-regulated and dysregulated pancreatic β-cell (MIN6) sublines. Endocrinology 144, 1368-1379
26. Fu, H., Subramanian, R. R. and Masters, S. C. (2000) 14-3-3 proteins: structure, function, and regulation. Annu. Rev. Pharmacol. Toxicol. 40, 617-647
27. 2+ channel. Nature (London) 352, 527-530
28. Piddini, E., Schmid, J. A., de Martin, R. and Dotti, C. G. (2001) The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 20, 4076-4087
29. Tseng, Y. H., Vicent, D., Zhu, J., Niu, Y., Adeyinka, A., Moyers, J. S., Watson, P. H. and Kahn, C. R. (2001) Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. Cancer Res. 61, 2071-2079
30. 2+ channels and their role in neurotransmitter release. Cell Calcium 24, 307-323
31. 2+ channels by gem. J. Biol. Chem. 280, 9308-9312